Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Understanding the interactions of zinc with zincophores and zinc transporters in fungal pathogens

2014/13/D/ST5/02868

Keywords:

zincophores fungal pathogens thermodynamics coordination modes

Descriptors:

  • ST5_14: Other related subjects
  • ST5_16:
  • ST5_24:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Wrocławski, Wydział Chemii

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Rowińska-Żyrek 

Number of co-investigators in the project: 2

Call: SONATA 7 - announced on 2014-03-17

Amount awarded: 448 620 PLN

Project start date (Y-m-d): 2015-02-12

Project end date (Y-m-d): 2018-09-11

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. potencjometr (140 000 PLN)
  2. spektrofotometr UV-Vis.

Information in the final report

  • Publication in academic press/journals (14)
  • Book publications / chapters in book publications (2)
  1. Candida albicans zincophore and zinc transporter interactions with Zn(II) and Ni(II)
    Authors:
    Łoboda D., Rowińska-Żyrek M.
    Academic press:
    Dalton Transactions (rok: 2018, tom: 47, strony: 2646-2654), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7dt04403h - link to the publication
  2. HENRYK — An endless source of metal coordination surprises
    Authors:
    Kołkowska P., Hecel A., Kędzierska D., Ostrowska M., Walencik P., Wątły J., Zdyb K., Spodzieja M., Rodziewicz-Motowidło S., Potocki S., Łuczkowski M., Gumienna-Kontecka E., Rowińska-Żyrek M.
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2016, tom: 163, strony: 258-265), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2016.02.030 - link to the publication
  3. Zinc binding site in Pra1, a zincophore from Candida albicans
    Authors:
    Łoboda D., Rowińska-Żyrek M.
    Academic press:
    Dalton Transactions (rok: 2017, tom: 46, strony: 13695-13703), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7dt01675a - link to the publication
  4. 'Coordination of Zn2+ and Cu2+ to the membrane disrupting fragment of amylin
    Authors:
    Rowińska-Żyrek M.
    Academic press:
    Dalton Transactions (rok: 2016, tom: 45, strony: 8099-8106), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6dt00628k - link to the publication
  5. Ag + complexes as potential therapeutic agents in medicine and pharmacy
    Authors:
    Hecel A., Kolkowska P., Krzywoszynska K., Szebesczyk A., Rowinska-Zyrek M., Kozlowski H.
    Academic press:
    Current Medicinal Chemistry (rok: 2019, tom: 26(4), strony: 624-647), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867324666170920125943 - link to the publication
  6. Zinc homeostasis at the bacteria/host interface—from coordination chemistry to nutritional immunity.
    Authors:
    Wątły J., Potocki S., Rowińska-Żyrek M.
    Academic press:
    Chemistry-A European Journal (rok: 2016, tom: 22, strony: 15992-16010), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/chem.201602376 - link to the publication
  7. Zn(II) - pramlintide : stability, binding sites and unexpected aggregation
    Authors:
    Łoboda D., Rowińska-Żyrek M.
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2017, tom: 174, strony: 150-155), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2017.06.008 - link to the publication
  8. Histidine tracts in human transcription factors: insight into metal ion coordination ability
    Authors:
    Hecel A., Wątły J., Rowińska-Żyrek M., Świątek-Kozłowska J., Kozłowski H.
    Academic press:
    Journal of Biological Inorganic Chemistry (rok: 2018, tom: 23, strony: 81-90), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1007/s00775-017-1512-x - link to the publication
  9. Impact of histidine spacing on modified polyhistidine tag : metal ion interactions
    Authors:
    Wątły J., Hecel A., Rowińska-Żyrek M., Kozłowski H.
    Academic press:
    Inorganica Chimica Acta (rok: 2018, tom: 472, strony: 119-126), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ica.2017.06.053 - link to the publication
  10. Metal interactions with the transmembrane region of HupE Ni2+ transporter explain its efficiency
    Authors:
    Rowińska-Żyrek M.
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2018, tom: 180, strony: 33-38), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2017.11.026 - link to the publication
  11. Periplasmic HupE region-Ni2+ interactions: Thermodynamics, binding mode and competition with Cu2+ and Zn2+
    Authors:
    Rowińska-Żyrek, M.
    Academic press:
    Inorganica Chimica Acta (rok: 2017, tom: 460, strony: 141-147), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ica.2016.08.007 - link to the publication
  12. Poly-Xaa Sequences in Proteins – Biological Role and Interactions with Metal Ions. Chemical and Medical Aspects
    Authors:
    Wątły J., Hecel A., Kołkowska P., Kozłowski H., Rowińska-Żyrek M.
    Academic press:
    Current Medicinal Chemistry (rok: 2018, tom: 25, strony: 22-48), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    http://www.eurekaselect.com/151986/article - link to the publication
  13. Fungal zinc homeostasis - a tug of war between the pathogen and host
    Authors:
    Walencik Paulina K., Wątły Joanna, Rowińska-Żyrek Magdalena
    Academic press:
    Current Medicinal Chemistry (rok: 2016, tom: 23, strony: 3717-3729), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867323666160817163834 - link to the publication
  14. Investigation on the metal binding sites of a putative Zn(II) transporter in opportunistic yeast species Candida albicans
    Authors:
    Belotti D., Łoboda D., Rowińska-Żyrek M., Remelli M.
    Academic press:
    New Journal of Chemistry (rok: 2018, tom: 42, strony: 8123-8130), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/C8NJ00533H - link to the publication
  1. The role of trace elements in living organisms
    Authors:
    Gumienna-Kontecka E., Rowińska-Żyrek M., Łuczkowski M.
    Book:
    Recent advances in trace elements (rok: 2018, tom: 1, strony: 177-206), Wydawca: Wiley
    Status:
    Published
  2. Nickel Binding Sites – Coordination Modes and Thermodynamics
    Authors:
    Rowińska-Żyrek M., Kozłowski H.
    Book:
    The biological inorganic chemistry of nickel (rok: 2017, tom: 1, strony: 43-59), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    link to the publication

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