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The impact of maternal diabetes on inflammasome NLRP3 activation in the offspring brain

2014/13/N/NZ7/00279

Keywords:

maternal diabetes offspring inflammasome NLRP3 hippocampal organotypic cultures

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ4_9: Systems neurobiology
  • NZ4_11: Metabolism

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Głombik 

Number of co-investigators in the project: 3

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 149 786 PLN

Project start date (Y-m-d): 2015-02-20

Project end date (Y-m-d): 2018-08-19

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (5)
  1. Inflammatory Consequences of Maternal Diabetes on the Offspring Brain: a Hippocampal Organotypic Culture Study.
    Authors:
    Katarzyna Głombik, Ewa Trojan, Anna Kurek, Bogusława Budziszewska, Agnieszka Basta-Kaim
    Academic press:
    Neurotoxicity Research (rok: 2019, tom: brak, strony: Epub ahead of print), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-019-00070-6 - link to the publication
  1. The impact of maternal diabetes on apoptotic and inflammatory processes in the offspring brain
    Authors:
    Katarzyna Głombik, Ewa Trojan, Anna Kurek, Joanna Ślusarczyk, Katarzyna Chamera, Agnieszka Basta-Kaim
    Conference:
    XXX Ogólnopolskie Seminarium pt. "Mechanizmy służące utrzymaniu życia i regulacji fizjologicznych" (rok: 2016, ), Wydawca: Małopolska Wyższa Szkoła im. Józefa Dietla w Krakowie
    Data:
    konferencja 25,06
    Status:
    Published
  2. The beneficial effect of glyburide on the evoked by maternal diabetes changes in the offspring brain
    Authors:
    Katarzyna Głombik, Ewa Trojan, Anna Kurek, Joanna Ślusarczyk, Katarzyna Chamera, Agnieszka Basta-Kaim
    Conference:
    12th EFIS-EJI Tatra Immunology Conference, Strebskie Pleso (rok: 2016, ), Wydawca: European Federation of Immunological Societies, Eureopean Journal of Immunology
    Data:
    konferencja 3-7.09
    Status:
    Published
  3. Influence of metformin on the maternal diabetes-induced changes in the hippocampus of rat offspring
    Authors:
    Katarzyna Głombik, Ewa Trojan, Anna Kurek, Joanna Ślusarczyk, Agnieszka Basta-Kaim
    Conference:
    NEURONUS 2016 IBRO & IRUN Neuroscience Forum (rok: 2016, ), Wydawca: Neuronus Forum
    Data:
    konferencja 22-24.04
    Status:
    Published
    DOI:
    link to the publication
  4. Glyburide prevents inflammatory factors release in the brain of diabetic dams offspring : new benefits of anti-diabetes drugs treatment
    Authors:
    Głombik Katarzyna, Trojan Ewa, Kurek Anna, Ślusarczyk Joanna, Chamera Katarzyna, Basta-Kaim Agnieszka
    Conference:
    XI Copernican International Young Scientists Conference (rok: 2017, ), Wydawca: Faculty of Chemistry, Nicolaus Copernicus University in Toruń, Poland
    Data:
    konferencja 28-30.06
    Status:
    Published
  5. Regulation of NLRP3 inflammasome gene expression in the hippocampus by maternal diabetes
    Authors:
    Katarzyna Głombik, Ewa Trojan, Anna Kurek, Bogusława Budziszewska, Agnieszka Basta-Kaim
    Conference:
    NEURONUS 2018 IBRO Neuroscience Forum (rok: 2018, ), Wydawca: Neuronus Forum
    Data:
    konferencja 20-22.04
    Status:
    Published

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