Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Estimation of surrogate of the effective drug concentration responsible for cardiac electrophysiological effect - numerical experiment utilising mechanistic pharmacokinetic and pharmacodynamic models.

2014/13/N/NZ7/00254

Keywords:

PBPK modeling proarrhythmic effect drug distribution

Descriptors:

  • NZ7_15: Toxicology
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Farmaceutyczny

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Zofia Tylutki 

Number of co-investigators in the project: 2

Call: PRELUDIUM 7 - announced on 2014-03-17

Amount awarded: 62 370 PLN

Project start date (Y-m-d): 2015-03-05

Project end date (Y-m-d): 2017-03-04

Project duration:: 24 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komputer (4 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Plasma vs heart tissue concentration in humans – literature data analysis of drugs distribution
    Authors:
    Zofia Tylutki, Sebastian Polak
    Academic press:
    Biopharmaceutics & Drug Disposition (rok: 2015, tom: 36, strony: 337-351), Wydawca: John Wiley & Sons Ltd
    Status:
    Published
    DOI:
    10.1002/bdd.1944 - link to the publication
  2. The effect of increasing amitriptyline doses on cardiomyocytes' electrophysiology - simulation study.
    Authors:
    Zofia Tylutki, Jokob Jornil, Sebastian Polak
    Academic press:
    Bio-Algorithms and Med-Systems (rok: 2016, tom: 12, strony: 33-38), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.1515/bams-2015-0043 - link to the publication
  3. A four-compartment PBPK heart model accounting for cardiac metabolism - model development and application.
    Authors:
    Zofia Tylutki, Sebastian Polak
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: Article number: 39494), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep39494 - link to the publication

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