Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Mitochondrial RNA decay and surveillance - comprehensive interdisciplinary studies.

2014/12/W/NZ1/00463

Keywords:

RNA mitochondria nuclease RNA-binding protein

Descriptors:

  • ST5_16:
  • NZ2_1: Molecular genetics
  • NZ1_3: Biophysics

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Międzynarodowy Instytut Biologii Molekularnej i Komórkowej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marcin Nowotny 

Number of co-investigators in the project: 16

Call: SYMFONIA 2

Amount awarded: 6 999 968 PLN

Project start date (Y-m-d): 2014-12-09

Project end date (Y-m-d): 2020-12-08

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Serwer plików i aplikacji (100 000 PLN)
  2. Cytometr przepływowy.
  3. Ultrawirówka (190 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  • Book publications / chapters in book publications (1)
  1. The Pet127 protein is a mitochondrial 5'-to-3' exoribonuclease from the PD-(D/E)XK superfamily involved in RNA maturation and intron degradation in yeasts
    Authors:
    Łabędzka-Dmoch K, Rażew M, Gapińska M, Piątkowski J, Kolondra A, Salmonowicz H, Wenda JM, Nowotny M, Golik P
    Academic press:
    RNA (rok: 2022, tom: 28, strony: 711-728), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna - link to the publication
  2. Human REXO2 controls short mitochondrial RNAs generated by mtRNA processing and decay machinery to prevent accumulation of double-stranded RNA
    Authors:
    Szewczyk M, Malik D, Borowski LS, Czarnomska SD, Kotrys AV, Klosowska-Kosicka K, Nowotny M, Szczesny RJ.
    Academic press:
    Nucleic Acids Research (rok: 2020, tom: 48(10), strony: 5572-5590), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkaa302 - link to the publication
  3. Mitochondrial Gene Expression and Beyond-Novel Aspects of Cellular Physiology
    Authors:
    Anna V. Kotrys, Roman J. Szczesny
    Academic press:
    Cells (rok: 2019, tom: 9, strony: nie dotyczy), Wydawca: MDPI (Multidisciplinary Digital Publishing Institute)
    Status:
    Published
    DOI:
    10.3390/cells9010017 - link to the publication
  4. Pervasive transcription of the mitochondrial genome in Candida albicans is revealed in mutants lacking the mtEXO RNase complex
    Authors:
    Łabędzka-Dmoch K, Kolondra A, Karpińska MA, Dębek S, Grochowska J, Grochowski M, Piątkowski J, Hoang Diu Bui T, Golik P.
    Academic press:
    RNA Biology (rok: 2021, tom: 18, strony: 303-317), Wydawca: TAYLOR & FRANCIS INC
    Status:
    Published
    DOI:
    10.1080/15476286.2021.1943929 - link to the publication
  5. Structural analysis of mtEXO mitochondrial RNA degradosome reveals tight coupling of nuclease and helicase components
    Authors:
    Razew M, Warkocki Z, Taube M, Kolondra A, Czarnocki-Cieciura M, Nowak E, Labedzka-Dmoch K, Kawinska A, Piatkowski J, Golik P, Kozak M, Dziembowski A, Nowotny M
    Academic press:
    Nature Communications (rok: 2018, tom: 9(1), strony: 97), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-017-02570-5 - link to the publication
  6. Quantitative proteomics revealed C6orf203/MTRES1 as a factor preventing stress-induced transcription deficiency in human mitochondria
    Authors:
    Anna V. Kotrys, Dominik Cysewski, Sylwia D. Czarnomska, Zbigniew Pietras, Lukasz S. Borowski, Andrzej Dziembowski, Roman J. Szczesny
    Academic press:
    Nucleic Acids Research (rok: 2019, tom: 47, strony: 7502-7517), Wydawca: Oxford Academic
    Status:
    Published
    DOI:
    10.1093/nar/gkz542 - link to the publication
  7. Yeast pentatricopeptide protein Dmr1 (Ccm1) binds a repetitive AU-rich motif in the small subunit mitochondrial ribosomal RNA
    Authors:
    J. Piątkowski, P. Golik
    Academic press:
    RNA (rok: 2020, tom: 26, strony: 1268-1282), Wydawca: Cold Spring Harbor Laboratory Press
    Status:
    Published
    DOI:
    10.1261/rna.074880.120 - link to the publication
  8. Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
    Authors:
    Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski & Roman J. Szczesny
    Academic press:
    Nature Communications (rok: 2018, tom: 9, strony: -), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-018-05007-9 - link to the publication
  9. Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
    Authors:
    Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski & Roman J. Szczesny
    Academic press:
    Molecular & Cellular Oncology (rok: 2018, tom: 5, strony: -), Wydawca: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/23723556.2018.1516452 - link to the publication
  1. High-Throughput Measurement of Mitochondrial RNA Turnover in Human Cultured Cells
    Authors:
    Anna V. Kotrys, Łukasz Borowski, Roman J. Szczesny
    Book:
    Mitochondrial Gene Expression. (rok: 2021, tom: n.d., strony: 133-146), Wydawca: Springer Nature
    Status:
    Published

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