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Immunological basis of IL-18 involvement in cellular response to Mycobacterium bovis BCG in immunocompromised and immunocompetent mice.

2013/11/B/NZ6/01304

Keywords:

M. bovis BCG IL-18 immunization immunosupression

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Łódzki, Wydział Biologii i Ochrony Środowiska

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Marek Fol 

Number of co-investigators in the project: 9

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 659 000 PLN

Project start date (Y-m-d): 2014-07-16

Project end date (Y-m-d): 2018-07-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (2)
  1. Effect of cyclophosphamide treatment on central and effector memory T cells in mice.
    Authors:
    Włodarczyk M., Ograczyk E., Kowalewicz-Kulbat M., Druszczyńska M., Rudnicka W., Fol M.
    Academic press:
    International Journal of Toxicology (rok: 2018, tom: brak, strony: 45301), Wydawca: SAGE journals
    Status:
    Published
    DOI:
    10.1177/1091581818780128 - link to the publication
  2. Immune response gene polymorphisms in tuberculosis.
    Authors:
    Fol M., Druszczynska M., Wlodarczyk M., Ograczyk E., Rudnicka W.
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62, strony: 633-640), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2015_1130 - link to the publication
  3. Mycobacterium bovis Wild-Type BCG or Recombinant BCG Secreting Murine IL-18 (rBCG/IL-18) Strains in Driving Immune Responses in Immunocompetent or Immunosuppressed Mice.
    Authors:
    Fol M., Włodarczyk M., Kowalewicz-Kulbat M., Druszczyńska M., Krawczyk K., Wawrocki S., Rudnicka W., Chmiela M.
    Academic press:
    Vaccines (rok: 2022, tom: 10, strony: 45312), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/vaccines10040615. - link to the publication
  4. Diversity and functionality of mycobacterial mycolic acids in relation to host-pathogen interactions.
    Authors:
    Druszczyńska M., Kowalski K., Wawrocki S., Fol M.
    Academic press:
    Current Medicinal Chemistry (rok: 2017, tom: 24, strony: 4267-4278), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/0929867324666170823130445 - link to the publication
  5. Immunosupresja - wymagający sprzymierzeniec na trudne czasy.
    Authors:
    Ograczyk E., Kowalewicz-Kulbat M., Wawrocki S., Fol M.
    Academic press:
    Postępy Higieny i Medycyny Doświadczalnej (rok: 2015, tom: 69, strony: 1299-1312), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    brak - link to the publication
  6. Infectious agents as stimuli of trained innate immunity.
    Authors:
    Rusek P., Wala M., Druszczyńska M., Fol M.
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: pii: E456), Wydawca: MDPI, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms19020456 - link to the publication
  7. Interleukin 18 (IL-18) as a target for immune intervention.
    Authors:
    Wawrocki S., Druszczynska M., Kowalewicz-Kulbat M., Rudnicka W.
    Academic press:
    Acta Biochimica Polonica (rok: 2016, tom: 63, strony: 59-63), Wydawca: Polskie Towarzystwo Biochemiczne i Komitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2015_1153 - link to the publication
  1. POSTER 1: Effect of BCG and rBCGmIL-18 on central and effector memory T cells in C57BL/6 mice in the model of immunosuppression induced by cyclophosphamide. POSTER 2: A comparison of selected immunological parameters in cyclophosphamide treated C57BL/6 and C3H mice immunized with BCG or rBCGmIL-18.
    Authors:
    POSTER 1: Kowalewicz-Kulbat M., Krawczyk K. Włodarczyk M., Druszczyńska M. Rudnicka W. Fol M.; POSTER 2: Włodarczyk M., Bednarek A., Kowalska J., Bromirski M., Druszczyńska M., Kowalewicz-Kulbat M., Krupa A., Rudnicka W., Fol M.
    Conference:
    5th European Congress of Immunology (rok: 2018, ), Wydawca: 2018 ECI
    Data:
    konferencja 2-5.09.2018
    Status:
    Published
    DOI:
    link to the publication
  2. POSTER 1: Mycobacteria ingestion and killing by alveolar macrophages isolated from immunocompetent or immunocompromised C57BL/6 and C3H mice immunized with M. bovis BCG or rBCGmIL-18. POSTER 2: Central and effector memory cel response in C57BL/6 mice immunized with Mycobacterium bovis BCG in the model of immunosuppression induced by cyclophosphamide. POSTER 3: Optimization of mouse cyclophosphamide-induced immunosuppression model.
    Authors:
    POSTER 1: Włodarczyk M., Bromirski M., Jerzykowska K., Wójcik E., Ograczyk E., Druszczyńska M., Kowalewicz-Kulbat M., Rudnicka W., Fol M.; POSTER 2: Kowalewicz-Kulbat M., Krawczyk K.T., Bekier A., Ograczyk E., Włodarczyk M., Druszczyńska M., Rudnicka W., Fol M.; POSTER 3: Ograczyk E., Włodarczyk M., Druszczyńska M., Kowalewicz-Kulbat M., Wawrocki S., Rudnicka W., Fol M.
    Conference:
    4th edition of scientific conference Microbiology in Health Care and Environmental Protection" - MIKROBIOT 2017, (rok: 2017, ), Wydawca: Polskie Towarzystwo Mikrobiologów
    Data:
    konferencja 19-21.09.2017
    Status:
    Published
    DOI:
    link to the publication

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