Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

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Remodeling plasma membrane lipid rafts as a tool to restore normal functions of skeletal muscle cells

2013/11/B/NZ5/03106

Keywords:

statins myopathies lipid rafts myoblasts signaling

Descriptors:

  • NZ5_1: Etiology of human diseases
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Szkoła Główna Gospodarstwa Wiejskiego w Warszawie, Wydział Medycyny Weterynaryjnej

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Arkadiusz Orzechowski 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 865 800 PLN

Project start date (Y-m-d): 2014-07-18

Project end date (Y-m-d): 2018-02-17

Project duration:: 43 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (3)
  • Book publications / chapters in book publications (2)
  1. Geranylgeraniol prevents statin-dependent myotoxicity in C2C12 muscle cells through RAP1 GTPase prenylation and cytoprotective autophagy
    Authors:
    Anna Jaśkiewicz, Beata Pająk, Anna Litwiniuk, Kaja Urbańska, Arkadiusz Orzechowski
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2018, tom: 2018, strony: 22 pages), Wydawca: Hindawi
    Status:
    Published
    DOI:
    10.1155/2018/6463807 - link to the publication
  2. The Many Faces of Rap1 GTPase
    Authors:
    Jaśkiewicz Anna, Pajak Beata, Orzechowski Arkadiusz
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 2848), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19102848 - link to the publication
  3. Artificial meat? Feasible approach based on the experience from cell culture studies.
    Authors:
    Orzechowski Arkadiusz
    Academic press:
    Journal of Integrative Agriculture (rok: 2015, tom: 14, strony: 217–221), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/S2095-3119(14)60882-0 - link to the publication
  4. Diverse Action of Selected Statins on Skeletal Muscle Cells - An Attempt to Explain the Protective Effect of Geranylgeraniol (GGOH) in Statin-Associated Myopathy (SAM)
    Authors:
    Jaśkiewicz Anna, Pajak Beata, Łabieniec-Watała Magdalena, De Palma Clara, Orzechowski Arkadiusz
    Academic press:
    Journal of Clinical Medicine (rok: 2019, tom: 8, strony: 694), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/jcm8050694 - link to the publication
  1. Importance of Plasma Membrane Nanodomains in Muscle Regeneration
    Authors:
    Orzechowski Arkadiusz
    Conference:
    BIT's 8th World Congress of Regenerative Medicine & Stem Cell 2015 (rok: 2015, ), Wydawca: BIT
    Data:
    konferencja 18-20 listopad 2015
    Status:
    Published
  2. Cytokines in Skeletal Muscle Growth and Decay
    Authors:
    Orzechowski Arkadiusz
    Conference:
    BIT's Annual World Congress of Regenerative Medicine & Stem Cell 2017 (rok: 2017, ), Wydawca: BIT
    Data:
    konferencja 14-16 listopada
    Status:
    Published
  3. Geranylgeraniol (GGOH) and Rap1 GTPase maintain cell viability retarded by statins in skeletal muscle.
    Authors:
    Jaśkiewicz Anna, Litwiniuk Anna, Pająk Beata, Urbańska Kaja, Orzechowski Arkadiusz
    Conference:
    XXVIIth Congress of the Polish Physiological Society (rok: 2017, ), Wydawca: Journal of Physiology and Pharmacology
    Data:
    konferencja 21-23 września
    Status:
    Published
  1. Cytokines in Skeletal Muscle Growth and Decay
    Authors:
    Orzechowski Arkadiusz
    Book:
    Plasticity of Skeletal Muscle. From Molecular Mechanism to Clinical Applications. (rok: 2017, tom: 1, strony: 113-140), Wydawca: Springer-Nature
    Status:
    Published
    DOI:
    link to the publication
  2. Importance of Plasma Membrane Nanodomains in Skeletal Muscle Regeneration
    Authors:
    Pająk Beata, Orzechowski Arkadiusz
    Book:
    Muscle Cell and Tissue (rok: 2015, tom: 5, strony: 107-142), Wydawca: Intech
    Status:
    Published
    DOI:
    link to the publication

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