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Information on the principal investigator and host institution

Information of the project and the call

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Mechanistic study on enantioseparations of the novel oxazolidinones

2013/11/D/NZ7/01230

Keywords:

oxazolidinones enantioseparations electromigration techniques spectroscopic techniques molecular modeling

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Narodowy Instytut Leków

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Katarzyna Michalska 

Number of co-investigators in the project: 5

Call: SONATA 6 - announced on 2013-09-16

Amount awarded: 581 976 PLN

Project start date (Y-m-d): 2014-10-07

Project end date (Y-m-d): 2018-10-06

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Laptop (3 500 PLN)
  2. Mikrowaga (30 000 PLN)
  3. Konduktometr (7 000 PLN)
  4. Aparat do wypalania okienka w kapilarze (3 000 PLN)
  5. Komputer z oprogramowaniem (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (10)
  1. Enantioselective recognition of sutezolid by cyclodextrin modified nonaqueous capillary electrophoresis, and an attempt to explain complex formation by means of infrared spectroscopy, NMR and molecular modelling
    Authors:
    Katarzyna Michalska, Wojciech Bocian, Elżbieta Bednarek, Barbara Pałys, Judyta Cielecka-Piontek
    Academic press:
    Journal of Pharmaceutical Analysis (rok: 2019, tom: 169, strony: 49-59), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Comprehensive spectral identification of key intermediates to the final product of the chiral pool synthesis of radezolid
    Authors:
    K. Michalska, E. Bednarek, E. Gruba, K. Lewandowska, M. Mizera, J. Cielecka-Piontek
    Academic press:
    Chemistry Central Journal (rok: 2017, tom: 11 (82), strony: 45307), Wydawca: SpringerOpen
    Status:
    Published
    DOI:
    10.1186/s13065-017-0309-x - link to the publication
  3. Enantioselective recognition of radezolid by cyclodextrin modified capillary electrokinetic chromatography and electronic circular dichroism
    Authors:
    Katarzyna Michalska, Ewa Gruba, Wojciech Bocian, Judyta Cielecka-Piontek
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2017, tom: 139, strony: 98-109), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2017.01.041 - link to the publication
  4. Application of spectroscopic methods (FT-IR, Raman, UV-CD and NMR) in studies of identification and optical purity of radezolid
    Authors:
    Katarzyna Michalska; Ewa Gruba; Mikołaj Mizera ; Elżbieta Bednarek; Wojciech Bocian; Judyta Cielecka-Piontek
    Academic press:
    Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy (rok: 2017, tom: 183, strony: 116-122), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.saa.2017.04.038183 - link to the publication
  5. Chiral separation of tedizolid using charge single isomer derivatives of cyclodextrins by capillary electrokinetic chromatography,
    Authors:
    Katarzyna Michalska, Ewa Gruba, Judyta Cielecka-Piontek, Elzbieta Bednarek
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2016, tom: 120, strony: 402-412), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jpba.2015.11.022 - link to the publication
  6. Nuclear Magnetic Resonance Spectroscopic Study of the Inclusion Complex of (R)-Tedizolid with HDAS-β-CD, β-CD, and gama-Cyclodextrin in Aqueous Solution
    Authors:
    Elżbieta Bednarek, Wojciech Bocian, Katarzyna Michalska
    Academic press:
    Journal of Pharmaceutical and Biomedical Analysis (rok: 2019, tom: 169, strony: 170-180), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  7. Infrared, Raman, and ultraviolet with circular dichroism analyses and theoretical calculations of tedizolid
    Authors:
    Katarzyna Michalska, Mikołaj Mizera, Kornelia Lewandowska, Judyta Cielecka-Piontek
    Academic press:
    Journal of Molecular Structure (rok: 2016, tom: 1115, strony: 136-143), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.molstruc.2016.02.098 - link to the publication
  1. Application of FT-IR and Raman spectroscopy for study of impurities of tedizolid enantiomers
    Authors:
    J. Cielecka-Piontek, K. Michalska, K. Lewandowska, M. Mizera,
    Conference:
    International Conference on Advanced Vibrational Spectroscopy (rok: 2015, ), Wydawca: ICAVS8
    Data:
    konferencja 12.07 - 17.07
    Status:
    Published
  2. Chiral separation of radezolid using charge single isomer derivatives of cyclodextrins by capillary electrokinetic
    Authors:
    Katarzyna Michalska, Ewa Gruba, Judyta Cielecka-Piontek
    Conference:
    31st International Symposium on Chromatography, ISC2016 (rok: 2016, ), Wydawca: University Collage Cork
    Data:
    konferencja 28-01.09
    Status:
    Published
  3. Chiral separation of tedizolid using charge single isomer derivatives of cyclodextrins by capillary electrokinetic chromatography.
    Authors:
    K. Michalska, E. Gruba, J. Cielecka-Piontek, E. Bednarek
    Conference:
    Recent Developments in pharmaceutical analysis (rok: 2015, ), Wydawca: Dipartamento Scienze Farmaceutiche, RDPA2015
    Data:
    konferencja 28.06 – 01.07
    Status:
    Published
  4. NMR and Molecular Modeling Studies of Tedezolid-Cyclodextrin Inclusion Complex
    Authors:
    Elżbieta Bednarek, Wojciech Bocian, Lech Kozerski, Jerzy Sitkowski, Katarzyna Michalska, Ewa Gruba
    Conference:
    XXVIIth INTERNATIONAL CONFERENCE on MAGNETIC RESONANCE in BIOLOGICAL SYSTEMS, Frontier of magnetic resonance in biological systems (rok: 2016, ), Wydawca: uniwersytet w Kioto
    Data:
    konferencja August 21 – 26
    Status:
    Published
  5. Molecular modelling and NMR Studies of Cyclodextrin Inclusion Complexes with New Oxazolidinone Antibiotics
    Authors:
    Wojciech Bocian, Elżbieta Bednarek, Katarzyna Michalska
    Conference:
    XXXIV European Congress on Molecular Spectroscopy (rok: 2018, ), Wydawca: EUCMOS 2018
    Data:
    konferencja 19.08-24.08.
    Status:
    Published
  6. Nonaqueous capillary electrophoretic separation of sutezolid enantiomers using charge single isomer derivatives of cyclodextrins
    Authors:
    Katarzyna Michalska, Ewa Gruba, Barbara Pałys, Judyta Cielecka-Piontek
    Conference:
    PBA2017 28 th Pharmaceutical and Biomedical Analysis Conference (rok: 2017, ), Wydawca: PBA
    Data:
    konferencja 02 - 05.07
    Status:
    Published
  7. Application of spectroscopic methods (FT-IR, Raman and NMR) for identification of radezolid. Experimental and dft-based approach
    Authors:
    Katarzyna Michalska; Ewa Gruba; Mikołaj Mizera ; Kornelia Lewandowska, Elżbieta Bednarek; Wojciech Bocian; Judyta Cielecka-Piontek
    Conference:
    1.XV Italian-Hungarian Symposium on Spectrochemistry PHARMACOLOGICAL RESEARCH AND ANALYTICAL APPROACHES, Pisa (rok: 2016, ), Wydawca: PISA UNIVERSITY PRESS
    Data:
    konferencja 12-16.06
    Status:
    Published
  8. Aqueous and nonaqueous capillary electrophoretic separation of oxazolidinone enantiomers using charge single isomer derivatives of cyclodextrins
    Authors:
    Katarzyna Michalska, Judyta Cielecka-Piontek
    Conference:
    The 11th International Symposium on Drug Analysis & the 29th International Symposium on Pharmaceutical and Biomedical Analysis (rok: 2018, ), Wydawca: KU Leuven
    Data:
    konferencja 09.09-12.09.
    Status:
    Published
    DOI:
    link to the publication
  9. SYNTHESIS and SPECTROSCOPIC INTERMEDIATES AND FINAL PRODUCTS OF INOVATIVE STEREOSELECTIVE SYNTHESIS OF RADEZOLID
    Authors:
    Katarzyna Michalska, Ewa Gruba, Mikołaj Mizera, Kornelia Lewandowska, Judyta Cielecka-Piontek
    Conference:
    52nd International Conference on Medicinal Chemistry, RICT2016, Caen, 6-8 July, Francja, (rok: 2016, ), Wydawca: Universite de Caen Normandie
    Data:
    konferencja 6-8.07
    Status:
    Published
  10. Spectroscopic identification of intermediates and final products supported by theoretical approach of the chiral pool synthesis of sutezolid
    Authors:
    Katarzyna Michalska, Ewa Gruba, Kornelia Lewandowska, Barbara Pałys, Mikołaj Mizera, Judyta Cielecka-Piontek
    Conference:
    International Symposium on Advances in Synthetic and Medicinal Chemistry (rok: 2017, ), Wydawca: EFMC-ASMC'17
    Data:
    konferencja 27 - 31.08
    Status:
    Published

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