Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Elucidation of the role of tumor-derived and exosomal arginases in avoiding immune responses by ovarian cancer

2013/11/B/NZ6/02790

Keywords:

arginases exosomes ovarian cancer immunesuppression

Descriptors:

  • NZ6_2: Clinical immunology
  • NZ6_1: Adaptive and innate immunity
  • NZ6_3: Animal immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Warszawski Uniwersytet Medyczny, I Wydział Lekarski

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Małgorzata Czystowska-Kuźmicz 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 1 359 699 PLN

Project start date (Y-m-d): 2014-07-16

Project end date (Y-m-d): 2018-07-15

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. pół-suchy zestaw do transferu z zasilaczem (22 000 PLN)
  2. Komputer Dell Optiplex 9030 All in One.
  3. System do elektroforezy żeli akryloamidowych formatu midi z wyposażeniem (5 000 PLN)
  4. System zasysający/pompa próżniowa do odsysania supernatantu.
  5. Mikrotom rotacyjny (60 000 PLN)
  6. Wirówka laboratoryjna z chłodzeniem i z wyposażeniem.
  7. Automatyczna wywoływarka do klisz RTG (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (5)
  1. Biological markers of prognosis, response to therapy and outcome in ovarian carcinoma
    Authors:
    Szajnik M, Czystowska-Kuźmicz M, Elishaev E, Whiteside TL
    Academic press:
    Expert Review of Molecular Diagnostics (rok: 2016, tom: 16 (8), strony: 811-826), Wydawca: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/14737159.2016.1194758 - link to the publication
  2. Small extracellular vesicles containing arginase-1 suppress T-cell responses and promote tumor growth in ovarian carcinoma
    Authors:
    Czystowska-Kuzmicz M., Sosnowska A., Nowis D., Ramji K., Szajnik M., Chlebowska-Tuz J., Wolinska E., Gaj P., Grazul M., Pilch Z., Zerrouqi A., Graczyk-Jarzynka A., Soroczynska K., Cierniak S., Koktysz R., Elishaev E., Gruca S., Stefanowicz A., Blaszczyk R., Borek B., Gzik A., Whiteside T., Golab J
    Academic press:
    Nature Communications (rok: 2019, tom: 10 (1), strony: 3000), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41467-019-10979-3 - link to the publication
  1. Arginase-1-containing exosomes induce supression of antitumour in vitro and in vivo immune response
    Authors:
    M. Czystowska-Kuzmicz, A. Sosnowska, J. Chlebowska-Tuz, K. Ramji, M. Szajnik, S. Gruca, A.Stefanowicz, D. Nowis, J. Golab
    Conference:
    Annual Meeting of the International Society of Extracellular Vesicles 2018 (rok: 2018, ), Wydawca: International Society of Extracellular Vesicles
    Data:
    konferencja 03.-06.05.
    Status:
    Published
    DOI:
    link to the publication
  2. Ovarian tumor cells suppress antitumor immune response through the release of arginase-1 containing exosomes
    Authors:
    M. Czystowska-Kuzmicz , M. Szajnik , K. Ramji, D. Nowis, S. Gruca , A. Stefanowicz , J. Gołab
    Conference:
    Annual Meeting of the international Society of Extracellular Vesicles 2017 (rok: 2017, ), Wydawca: International society of Extracellular Vesicles
    Data:
    konferencja 18-21.05.
    Status:
    Published
    DOI:
    link to the publication
  3. Ovarian cancer cell release arginase-1 containing exosomes to suppress antitumor immune response
    Authors:
    M. Czystowska-Kuzmicz, A. Sosnowska, J. Chlebowska-Tuz, K. Ramji, M. Szajnik, D. Nowis, S. Gruca, A. Stefanowicz, J. Golab
    Conference:
    8th International conference on Tumor Microenvironment (rok: 2018, ), Wydawca: Springer Netherlands
    Data:
    konferencja 10.-14.06.
    Status:
    Published
    DOI:
    link to the publication
  4. Ovarian cancer cells release arginase-1 containing exosomes to suppress antitumor immune response
    Authors:
    M. Czystowska-Kuzmicz , M. Szajnik , K. Ramji, D. Nowis, S. Gruca , A. Stefanowicz , J. Gołab
    Conference:
    AACR meeting 2017 (rok: 2017, ), Wydawca: AACR
    Data:
    konferencja 1.-5.04
    Status:
    Published
    DOI:
    link to the publication
  5. Role of tumor-derived exosomal arginase-1 in avoiding immune responses by ovarian cancer
    Authors:
    M. Czystowska-Kuzmicz , M. Szajnik , S. Gruca , A. Stefanowicz , J. Gołab
    Conference:
    ESMO Symposium on Immuno-Oncology 2016 (rok: 2016, ), Wydawca: European Society for Medical Oncology
    Data:
    konferencja 04-06.11.2016
    Status:
    Published
    DOI:
    link to the publication

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