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Information on the principal investigator and host institution

Information of the project and the call

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Evaluation of histopathological changes in the rats tissues after acute and chronic administration of the compounds from tetrahydroisoquinolines group - in vivo, in vitro and in silico studies.

2013/11/N/NZ7/00358

Keywords:

1,2,3,4-Tetrahydroisoquinoline 1-Methyl-1,2,3,4-tetrahydroisoquinoline histopathology liver kidneys lungs ADMET

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Edyta Możdżeń 

Number of co-investigators in the project: 3

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 99 983 PLN

Project start date (Y-m-d): 2014-08-05

Project end date (Y-m-d): 2017-01-04

Project duration:: 29 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (2)
  • Book publications / chapters in book publications (1)
  1. 1-Methyl-1,2,3,4-tetrahydroisoquinoline - the toxicological research on an exo/endogenous amine with antidepressant-like activity - in vivo, in vitro and in silico studies
    Authors:
    Edyta Mozdzen, Izabela Babinska, Jacek Wojcikowski, Lucyna Antkiewicz-Michaluk
    Academic press:
    Pharmacological Reports (rok: 2019, ), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.pharep.2019.06.016 - link to the publication
  1. Toxicological research of 1-methyl-1,2,3,4-tetrahydroisoquinoline an exo/endogenous amine with antidepressant-like activity – in vivo, in vitro and in silico studies
    Authors:
    Mozdzen E., Babinska I., Wojcikowski J., Antkiewicz-Michaluk L.
    Conference:
    The 13th International Symposium MOLECULAR BASIS OF PATHOLOGY AND THERAPY IN NEUROLOGICAL DISORDERS The 4th International Conference STEM CELLS: THERAPEUTIC OUTLOOK FOR CENTRAL NERVOUS SYSTEM DISORDERS (rok: 2016, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 17-18 listopada 2016
    Status:
    Published
  2. TOXICOLOGICAL RESEARCH 1,2,3,4-TETRAHYDROISOQUINOLINE AN EXO/ENDOGENOUS AMINE WITH ANTIDEPRESSANT-LIKE ACTIVITY – IN VIVO, IN VITRO AND IN SILICO STUDIES
    Authors:
    Edyta Możdżeń, Izabella Babińska, Jacek Wójcikowski, Paulina Rachwalska, Lucyna Antkiewicz-Michaluk
    Conference:
    5th International MNS Meeting 2015 (rok: 2015, ), Wydawca: Mediterranean Neuroscience Society
    Data:
    konferencja 12-15 czerwca 2015
    Status:
    Published
  1. Endogenne aminy z grupy tetrahydroizochinoliny w badaniach in silico
    Authors:
    Możdżeń E., Antkiewicz-Michaluk L.
    Book:
    Fizyczne, chemiczne i biologiczne aspekty nauki (rok: 2016, tom: nie dotyczy, strony: 56-65), Wydawca: Wydawnictwo Naukowe TYGIEL sp z. o. o.
    Status:
    Published

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