Projects funded by the NCN
Synthesis of pyridopyrimidine derivatives, dual affinity ligands for 5-HT1AR and SERT.
2013/11/B/NZ7/01638
Keywords:
organic synthesis antidepressants SERT and 5-HT1AR ligands
Descriptors:
- NZ7_14: Pharmacy, pharmacotherapy, pharmacology
- ST5_16:
Panel:
NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology
Host institution :
Warszawski Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 10
Call: OPUS 6 - announced on 2013-09-16
Amount awarded: 501 660 PLN
Project start date (Y-m-d): 2014-08-07
Project end date (Y-m-d): 2018-08-06
Project duration:: 48 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Aparat do oznaczania temperatur topnienia Electrothermal.
- Wyparka próżniowa rotacyjna z membranową pompą próżniową (37 000 PLN)
- Oprogramowanie Gaussian (30 000 PLN)
- Mieszadło magnetyczne z czujnikiem temperatury (2 szt.) (8 000 PLN)
Information in the final report
- Publication in academic press/journals (2)
- Synthesis of new 5,6,7,8-tetrahydropyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligandsAuthors:Grzegorz Ślifirski, Marek Król, Jerzy Kleps, Piotr Podsadni, Mariusz Belka, Tomasz Bączek, Agata Siwek, Katarzyna Stachowicz, Bernadeta Szewczyk, Gabriel Nowak, Andrzej Bojarski, Anna E. Kozioł, Jadwiga Turło, Franciszek HeroldAcademic press:European Journal of Medicinal Chemistry (rok: 2019, tom: 180, strony: 383-397), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.emech.2019.07.027 - link to the publication
- Synthesis of novel pyrido[1,2-c]pyrimidine derivatives with rigidized tryptamine moiety as potential SSRI and 5-HT1A receptor ligandsAuthors:Grzegorz Ślifirski; Marek Król, Ph.D.; Jerzy Kleps; Szymon Ulenberg; Mariusz Belka; Tomasz Bączek; Agata Siwek; Katarzyna Stachowicz; Bernadeta Szewczyk; Gabriel Nowak; Andrzej Bojarski; Anna E Kozioł; Jadwiga Turło; Franciszek HeroldAcademic press:European Journal of Medicinal Chemistry (rok: 2019, tom: 166, strony: 144-158), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.ejmech.2019.01.031 - link to the publication