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Information of the project and the call

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The determination of the ability of the low molecular weight polysiloxanes (silicones) to penetrate and permeate throught the human skin.

2013/11/B/NZ7/02076

Keywords:

penetration stratum corneum permeation across skin low molecular polysiloxanes low molecular silicones absorption across skin

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Gdański Uniwersytet Medyczny, Wydział Farmaceutyczny z Oddziałem Medycyny Laboratoryjnej

woj. pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Krystyna Pieńkowska 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 374 350 PLN

Project start date (Y-m-d): 2014-08-07

Project end date (Y-m-d): 2017-08-06

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer wraz z peryferiami i UPS (11 600 PLN)
  2. Komory przepływowo-dyfuzyjne typu Franza (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (6)
  1. Direct human contact with siloxanes (silicones) – safety or risk Part 1. Characteristics of siloxanes (silicones)
    Authors:
    Krystyna Mojsiewicz-Pieńkowska, Marzena Jamrógiewicz, Katarzyna Szymkowska, Dominika Krenczkowska
    Academic press:
    Frontiers in Pharmacology Predictive Toxicology (rok: 2016, tom: 7, Article 132, strony: 45299), Wydawca: Frontiers Open-access journals
    Status:
    Published
    DOI:
    10.3389/fphar.2016.00132 - link to the publication
  2. The consequences of overcoming the human skin barrier by siloxanes (silicones) Part 1. Penetration and permeation depth study of cyclic methyl siloxanes
    Authors:
    Dominika Krenczkowska, Krystyna Mojsiewicz-Pieńkowska, Bartosz Wielgomas, Krzysztof Cal, Rafał Bartoszewski, Sylwia Bartoszewska, Zbigniew Jankowski
    Academic press:
    Chemosphere (rok: 2018, tom: brak ostat., strony: brak ostatecz. stron), Wydawca: Elsevier
    Status:
    Accepted for publication
    DOI:
    10.1016/j.chemosphere.2018.09.154 - link to the publication
  3. Evolution of consciousness of exposure to siloxanes – review of publications
    Authors:
    Krystyna Mojsiewicz-Pieńkowska, Dominika Krenczkowska
    Academic press:
    Chemosphere (rok: 2018, tom: vol. 191, strony: 204-217), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.045 - link to the publication
  1. The impact of low molecular weight polysiloxanes on the skin barrier
    Authors:
    KRYSTYNA MOJSIEWICZ-PIEŃKOWSKA, KATARZYNA SZYMKOWSKA, D. Glamowska, KRZYSZTOF CAL, ZBIGNIEW JANKOWSKI
    Conference:
    1st European Conference on Pharmaceutics : Drug Delivery, Reims, France, 13-14 April 2015 (rok: 2015, ), Wydawca: APV Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik
    Data:
    konferencja 13-14 April 2015
    Status:
    Published
  2. What are the consequences of impact of the polysiloxanes (silicones) on the skin barrier?
    Authors:
    KRYSTYNA MOJSIEWICZ-PIEŃKOWSKA, KATARZYNA SZYMKOWSKA, DOMINIKA GLAMOWSKA, KRZYSZTOF CAL, ZBIGNIEW JANKOWSKI, MARZENA JAMRÓGIEWICZ
    Conference:
    5th Global Pharmacists Annual Meeting, Brisbane, Australia, July 14-15, 2016 (rok: 2016, ), Wydawca: J. Pharm. Drug Deliv. Res. 2016; vol. 5, nr 3, s. 25
    Data:
    konferencja July 14-15, 2016
    Status:
    Published
  3. Loss of the skin barrier after dermal application of the low molecular methyl siloxanes (volatile methyl siloxanes, VMS silicones)
    Authors:
    Dominika Glamowska, Katarzyna Szymkowska, Krystyna Mojsiewicz- Pieńkowska, Krzysztof Cal, Zbigniew Jankowski
    Conference:
    ICT 2015 : XIII International Conference on Toxicology, London, United Kingdom (rok: 2015, ), Wydawca: WASET World Academy of Science, Engineering and Technology
    Data:
    konferencja February 16-17, 2015
    Status:
    Published
  4. Ability of low molecular cyclic methyl siloxanes to penetrate and permeate through the skin barrier
    Authors:
    Dominika Krenczkowska, Krystyna Mojsiewicz- Pieńkowska, Krzysztof Cal, Zbigniew Jankowski
    Conference:
    10th World Meeting on Pharmaceutics, Biopharmaceutics and Pharmaceutical Technology, Glasgow, United Kingdom, 4 to 7 April 2016 (rok: 2016, ), Wydawca: ResearchPharm
    Data:
    konferencja 4 to 7 April 2016
    Status:
    Published
  5. Penetration depth study of linear siloxanes (silicones) through human skin.
    Authors:
    Katarzyna Szymkowska, Krystyna Mojsiewicz-Pieńkowska
    Conference:
    18th International Conference on Pharmacetical Drug Design, Development and Side Effects (rok: 2016, ), Wydawca: World Academy of Science, Engineering and Technology International Journal of Pharmacological and Pharmaceutical Sciences
    Data:
    konferencja 25-26 April
    Status:
    Published
  6. Consequences of overcoming the skin barrier by low molecular cyclic and linear methyl siloxanes (silicones)
    Authors:
    KRYSTYNA MOJSIEWICZ-PIEŃKOWSKA, KATARZYNA SZYMKOWSKA, Dominika Glamowska, KRZYSZTOF CAL, ZBIGNIEW JANKOWSKI, MARZENA JAMRÓGIEWICZ, RAFAŁ BARTOSZEWSKI, SYLWIA BARTOSZEWSKA, MICHAŁ PIKUŁA
    Conference:
    5th International Conference on Clinical & Experimental Dermatology, New Orleans, USA, (rok: 2015, ), Wydawca: J. Clin. Exp. Dermatol. Res. 2015; vol. 6, nr 3, s. 60
    Data:
    konferencja July 13-15, 2015
    Status:
    Published

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