Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The alpha-ketoglutarate (AKG) as the stymulator of the osteoblast bone-forming activity and the regulator of osteoblasts's function in vitro

2013/11/B/NZ4/04557

Keywords:

alpha ketoglutarate osteoblasts differentiation mineralisation GPR80/99

Descriptors:

  • NZ4_2: Physiology
  • NZ5_7: Human disease treatment
  • NZ7_12: Prevention of human diseases

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Marii Curie-Skłodowskiej, Wydział Biologii i Biotechnologii

woj. lubelskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Martyna Kandefer-Szerszeń 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 563 290 PLN

Project start date (Y-m-d): 2014-07-23

Project end date (Y-m-d): 2018-07-22

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wyposażenie do mikroskopu (kamera cyfrowa z oprogramowaniem).
  2. wytrząsarka do mikropłytek (2 500 PLN)
  3. Płuczka do płytek 96-dołkowych (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (3)
  1. Alpha ketoglutarate exerts a pro-osteogenic effect in osteoblast cell lines through activation of JNK and mTOR/S6K1/S6 signaling pathways.
    Authors:
    Aleksandra Żurek, Magdalena Mizerska-Kowalska, Adrianna Sławińska-Brych, Katarzyna Kaławaj, Agnieszka Bojarska-Junak, Martyna Kandefer-Szerszeń, Barbara Zdzisińska
    Academic press:
    Toxicology and Applied Pharmacology (rok: 2019, tom: 374, strony: 53-64), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.taap.2019.04.024 - link to the publication
  2. Alpha-Ketoglutarate as a Molecule with Pleiotropic Activity – Well Known and Novel Possibilities of Therapeutic Use
    Authors:
    Barbara Zdzisińska, Aleksandra Żurek, Martyna Kandefer-Szerszeń
    Academic press:
    Archivum Immunologiae et Therapiae Experimentalis (rok: 2017, tom: 65, strony: 21-36), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00005-016-0406-x. - link to the publication
  1. Alpha ketoglutarate enhances osteoprotegerin production and downregulates the ratio RANKL/OPG in osteoblast cell lines in vitro
    Authors:
    Katarzyna Kaławaj, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Aleksandra Żurek, Agnieszka Bojarska-Junak, Martyna Kandefer-Szerszeń, Barbara Zdzisińska,
    Conference:
    The XVIth Congress of the Polish Society of Experimental and Clinical Immunology (rok: 2017, ), Wydawca: Termedia Publishing House LTD
    Data:
    konferencja 8-10 czerwca
    Status:
    Published
  2. Alpha ketoglutarate (AKG) induces apoptosis in osteosarcoma cells in vitro through the activation of JNK MAP kinase
    Authors:
    Katarzyna Kaławaj, Adrianna Sławińska-Brych, Magdalena Mizerska-Kowalska, Aleksandra Żurek, Agnieszka Bojarska-Junak, Martyna Kandefer-Szerszeń, Barbara Zdzisńska
    Conference:
    BIO 2018 Congress (rok: 2018, ), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 18-21 września
    Status:
    Published
    DOI:
    link to the publication
  3. Alpha ketoglutarate promotes differentiation and mineralization of osteoblasts in vitro
    Authors:
    Aleksandra Żurek, Magdalena Mizerska-Kowalska, Adrianna Sławińska-Brych, Katarzyna Kaławaj, Agnieszka Bojarska-Junak, Martyna Kandefer-Szerszeń, Barbara Zdzisńska
    Conference:
    BIO 2018 Congress (rok: 2018, ), Wydawca: Polish Biochemical Society and the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Data:
    konferencja 18-21 września
    Status:
    Published

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