Projects funded by the NCN
Influence of AKT signaling pathway on CD20 expression and antitumor activity of therapeutic monoclonal antibodies.
2013/11/B/NZ5/03240
Keywords:
B lymphocytes CD20 antigen transcriptional regulation AKT PI3K TLR dendritic cells
Descriptors:
- NZ6_2: Clinical immunology
- NZ6_8: Other related subjects
- NZ5_7: Human disease treatment
Panel:
NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)
Host institution :
Warszawski Uniwersytet Medyczny, I Wydział Lekarski
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 6
Call: OPUS 6 - announced on 2013-09-16
Amount awarded: 1 074 759 PLN
Project start date (Y-m-d): 2014-08-08
Project end date (Y-m-d): 2017-08-07
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Dewar do ciekłego azotu (do przechowywania kriotubek).
- Oprogramowanie do komputera (2 szt.) (4 000 PLN)
- Zamrażarka niskotemperaturowa (-86C) (68 000 PLN)
- Odyssey Fc (system do techniki Western blot) (185 000 PLN)
- Zestaw do transferu białek (do techniki Western blotting).
Information in the final report
- Publication in academic press/journals (2)
- Articles in post-conference publications (10)
- FOXO1 promotes resistance of non-Hodgkin lymphomas to anti-CD20-based therapy.Authors:Pyrzynska B., Dwojak M. , Zerrouqi A. , Morlino G., Zapala P., Miazek N., Zagozdzon A., Bojarczuk K., Bobrowicz M., Siernicka M., Machnicki M.M., Gobessi S., Barankiewicz J., Lech-Maranda E., Efremov D.G., Juszczynski P., Calado D., Golab J., Winiarska M.Academic press:OncoImmunology (rok: 2018, tom: 7(5), strony: e1423183 (9 stron)), Wydawca: Taylor & Francis GroupStatus:PublishedDOI:10.1080/2162402X.2017.1423183 - link to the publication
- HDAC6 inhibition up-regulates CD20 levels and increases the efficacy of anti-CD20 monoclonal antibodies.Authors:Bobrowicz M., Dwojak M., Pyrzynska B., Stachura J., Muchowicz A., Berthel E., Dalla Venezia N., Kozikowski M., Siernicka M., Miazek N., Zapala P., Domagala A., Bojarczuk K., Malenda A., Barankiewicz J., Graczyk-Jarzynka A., Zagozdzon A., Gabrysiak M., Diaz J.J., Karp M., Lech-Maranda E., Firczuk M., Giannopoulos K., Efremov D.G., Laurenti L., Baatout D., Frenzel L., Malinowska A., Slabicki M., Zenz T., Zerrouqi A., Golab J., Winiarska M.Academic press:Blood (rok: 2017, tom: 130(14), strony: 1628-1638), Wydawca: American Society of HematologyStatus:PublishedDOI:10.1182/blood-2016-08-736066 - link to the publication