Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Studies on the mechanism and applications of the chemoenzymatic rearrangement reaction of the unsaturated carboxylic acids.

2013/11/B/ST5/02199

Keywords:

unsaturated carboxylic acids biocatalysis rearrangement alkylation selectivity

Descriptors:

  • ST4_11: Coordination and supramolecular chemistry
  • ST5_18:
  • ST4_14: Catalysis

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Instytut Chemii Organicznej PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Ostaszewski 

Number of co-investigators in the project: 5

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 952 460 PLN

Project start date (Y-m-d): 2014-11-03

Project end date (Y-m-d): 2018-01-02

Project duration:: 38 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wirówka (5 000 PLN)
  2. Inkubator z wytrzasaniem.
  3. SYSTEM DO CHROMATOGRAFII ŻELOWEJ FLASH WRAZ Z WYPOSAŻENIEM (kardridże, detektor z detekcją laserową) (195 000 PLN)
  4. Mieszadła magnetyczne (dwa zestawy) (2 szt.) (6 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  1. Enzymatic synergism in the synthesis of β-keto esters
    Authors:
    C. Wiśniewska, D. Koszelewski, M. Zysk, , S. Kłossowski, A. Żądło, A. Brodzka and R. Ostaszewski
    Academic press:
    European Journal of Organic Chemistry (rok: 2015, tom: 24, strony: 5432-5437), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/ejoc.201500676 - link to the publication
  2. Self-immolative Versatile Fluorogenic Probes for Screening of Hydrolytic Enzymes Activity
    Authors:
    A. Żądło, M. Szczygieł, D. Koszelewski, D. Paprocki, R. Ostaszewski,
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2016, tom: 14, strony: 9146-9150), Wydawca: ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE, SCIENCE PARK, MILTON RD, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND
    Status:
    Published
    DOI:
    10.1039/C6OB01488G - link to the publication
  3. The mechanistic promiscuity of the enzymatic esterification of chiral carboxylic acids
    Authors:
    A. Brodzka, D. Koszelewski, M. Zysk, R. Ostaszewski
    Academic press:
    Catalysis Communications (rok: 2018, tom: 106, strony: 82-86), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.catcom.2017.12.019 - link to the publication
  4. Mixed Carbonates as Useful Substrates for a Fluorogenic Assay for Lipases and Esterases
    Authors:
    A. Żądło, D. Koszlewski, F. Borys, R. Ostaszewski
    Academic press:
    ChemBioChem (rok: 2015, tom: 16, strony: 677-682), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.201402528 - link to the publication
  5. A Convenient Stereoselective Synthesis of 5-Hydroxy-3-oxoesters and 3-Hydroxy-5-oxoesters
    Authors:
    A. Żadło-Dobrowolska, J. H. Schrittwieser, B. Grischek, D. Koszelewski, W. Kroutil, R. Ostaszewski
    Academic press:
    Tetrahedron Asymmetry (rok: 2017, tom: 28, strony: 797-802), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.05.005 - link to the publication
  6. Intracolonic Hydrogen Sulfide Lowers Blood Pressure in Rat
    Authors:
    L. Tomasova; L. Dobrowolski, H. Jurkowa, M. Wróbel, T. Huc, K. Ondaris, R. Ostaszewski, M. Ufnal
    Academic press:
    Nitric Oxide (rok: 2016, tom: 14, strony: 50-58), Wydawca: ACADEMIC PRESS INC ELSEVIER SCIENCE, 525 B ST, STE 1900, SAN DIEGO, CA 92101-4495 USA
    Status:
    Published
    DOI:
    10.1016/j.niox.2016.09.007 - link to the publication
  7. Studies on asymmetric synthesis of bicyclomycin precursors. A chemoenzymatic route to chiral 2,5-diketopiperazines and 2-oxa-bicyclo[4.2.2]decane-8,10-diones
    Authors:
    A. Fryszkowska, D. Kolszelewski, R. Ostaszewski
    Academic press:
    Tetrahedron Asymmetry (rok: 2017, tom: 28, strony: 1127-1134), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.08.004 - link to the publication
  8. Enzyme mediated kinetic resolution of δ-hydroxy-α,β-unsaturated esters as a route to optically active δ-lactones
    Authors:
    D. Koszelewski, D. Paprocki, A. Brodzka, R. Ostaszewski
    Academic press:
    Tetrahedron Asymmetry (rok: 2017, tom: 28, strony: 809-818), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tetasy.2017.05.003 - link to the publication
  9. Evaluation of Pseudoenantiomeric Mixed Carbonates as Efficient Fluorogenic Probes for Enantioselectivity Screening
    Authors:
    A. Żądło, D. Koszlewski, F. Borys, R. Ostaszewski
    Academic press:
    ChemBioChem (rok: 2016, tom: 17, strony: 71-76), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cbic.201500509 - link to the publication
  10. Dynamic Kinetic Resolution of 3-aryl-4-Pentenoic Acids
    Authors:
    D. Koszelewski, A. Brodzka, A. Żądło, D. Paprocki D., D. Trzepizur , M. Zysk, R. Ostaszewski
    Academic press:
    ACS Catal. (rok: 2016, tom: 6, strony: 3287-3292), Wydawca: AMER CHEMICAL SOC 1155 16TH ST, NW, WASHINGTON, DC 20036 USA
    Status:
    Published
    DOI:
    10.1021/acscatal.6b00271 - link to the publication
  11. Evaluation of a new protocol for enzymatic dynamic kinetic resolution of 3-hydroxy-3-(aryl)propanoic acids
    Authors:
    D. Koszelewski, M. Zysk, A. Brodzka, A. Żądło, D. Paprocki, R. Ostaszewski
    Academic press:
    Organic & Biomolecular Chemistry (rok: 2015, tom: 13, strony: 11014-11020), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5ob01380a - link to the publication
  12. Polymer membrane ion-selective electrodes as a convenient tool for lipases and esterases assays
    Authors:
    M. Cieplak, R. Ostaszewski
    Academic press:
    Preparative Biochem. Biotech., (rok: 2017, tom: 47, strony: 673-677), Wydawca: Taylor&Francis
    Status:
    Published
    DOI:
    10.1080/10826068.2017.1303611 - link to the publication

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