Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Molecular functions of the human SUV3 gene

2013/11/B/NZ1/00089

Keywords:

human helicase mitochondria RNA metabolism

Descriptors:

  • NZ2_1: Molecular genetics
  • NZ3_8: Stem cell biology
  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Centrum Nowych Technologii Uniwersytetu Warszawskiego

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Piotr Stępień 

Number of co-investigators in the project: 6

Call: OPUS 6 - announced on 2013-09-16

Amount awarded: 842 400 PLN

Project start date (Y-m-d): 2014-09-25

Project end date (Y-m-d): 2018-09-24

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. homogenizator.

Information in the final report

  • Publication in academic press/journals (12)
  1. Mammalian cell defence mechanisms against the cytotoxicity of NaYf4:(Er,Yb,Gd) nanoparticles
    Authors:
    B. Sikora, P. Kowalik, J. Mikulski, J. Fronc, M. Szewczyk, A. Konopka, K. Zajdel, R. Mikayev, K. Sobczak, W. Zaleszczyk, A. Borodziuk, J. Rybusinski, J Szczytko, A. Sienkiewicz, T. Wojciechowski, P. Stepien, M. Frontczak-Baniewicz, M Lapinski, G. Wilczynski, W. Paszkowicz, A. Twardowski, D. Elbaum
    Academic press:
    Nanoscale (rok: 2017, tom: 9, strony: 14259-14271), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c7nr03705h - link to the publication
  2. Mitochondrial biogenesis and neural differentiation of human iPSC is modulated by idebenone in a developmental stage-dependent manner
    Authors:
    J. Augustyniak, J. Lenart, M. Zychowicz, P.P.Stepien, L. Buzanska
    Academic press:
    Biogerontology (rok: 2017, tom: 18, strony: 665-677), Wydawca: Springer Verlag
    Status:
    Published
    DOI:
    10.1007/s10552-017-9718-4 - link to the publication
  3. Sensitivity of hiPSC-derived neural stem cells (NSC) to Pyrroloquinoline quinone depends on their developmental stage
    Authors:
    J. Augustyniak, J. Lenart, M. Zychowicz, G. Lipka, P. Gaj, M. Kolanowska, PP. Stepien, L. Buzanska
    Academic press:
    Toxicology in vitro (rok: 2017, tom: 45, strony: 434-444), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.tiv.2017.05.017 - link to the publication
  4. Single-step synthesis of Er3+ and Yb3+ ions doped molybdate/Gd2O3 core-shell nanoparticles for biomedical imaging
    Authors:
    Kamińska I1, Elbaum D, Sikora B, Kowalik P, Mikulski J, Felcyn Z, Samol P, Wojciechowski T, Minikayev R, Paszkowicz W, Zaleszczyk W, Szewczyk M, Konopka A, Gruzeł G, Pawlyta M, Donten M, Ciszak K, Zajdel K, Frontczak-Baniewicz M, Stępień P, Łapiński M, Wilczyński G, Fronc K.
    Academic press:
    Nanotechnology (rok: 2018, tom: 12, strony: 29(2):025702), Wydawca: IOP Publishing
    Status:
    Published
    DOI:
    10.1088/1361-6528/aa9974 - link to the publication
  5. Reference gene validation via RT-qPCR for human iPSC-derived neural stem cells and neural progenitors
    Authors:
    J. Augustyniak, J. Lenart, G. Lipka, P.P. Stępień
    Academic press:
    Molecular Neurobiology (rok: 2019, tom: 56, strony: 6820-6832), Wydawca: Springer Verlag
    Status:
    Published
    DOI:
    10.1007/s12035-019-1538-x - link to the publication
  6. Upconrverting/magnetic Gd2O3:(Er3+, Yb3+, Zn2+) nanoparticles for biological applications:effect of Zn2+ doping
    Authors:
    I. Kaminska, K. Fronc, B. Sikora, M. Mouawad, A. Siemiarczuk, M. Szewczyk, K. Sobczak, T. Wojciechowski, W. Zaleszczyk, R. Minikayev, W. Paszkowicz, P. Stępień, P. Dziawa, K. Ciszak, D. Piatkowski, S. Maćkowski, M. Kaliszewski, M. Włodarski, J. Młyńczak, K. Kopczyński, M. Łapiński, D. Elbaum
    Academic press:
    RSC Advances (rok: 2015, tom: 5, strony: 78361-78373), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5ra11888c - link to the publication
  7. Upconversion fluorescence imaging of HeLa cells using ROS generating SiO2-coated lanthanide-doped NaYF4 nanoconstructs
    Authors:
    P. Kowalik, D. Elbaum, M. Szewczyk, P. Stepien et. al
    Academic press:
    RSC Advances (rok: 2017, tom: 7, strony: 30262-30273), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c6ra2538k - link to the publication
  8. Dedicated surveillance mechanism controls G-quadruplex forming non-coding RNAs in human mitochondria
    Authors:
    Pietras Z, Wojcik MA, Borowski LS, Szewczyk M, Kulinski TM, Cysewski D, Stepien PP, Dziembowski A, Szczesny RJ.
    Academic press:
    Nature Commun. (rok: 2018, tom: Jul 2;9(1):2558, strony: 2558-61), Wydawca: Springer Nature
    Status:
    Published
    DOI:
    10.1038/s41467-018-05007-9 - link to the publication
  9. Human SUV3 helicase regulates growth rate of the HeLa cells and can localize in the nucleoli
    Authors:
    M. Szewczyk, N.Fedoryszak-Kuska,K. Tkaczuk, J.Dobrucki, A. Waligórska, P.P.Stępień
    Academic press:
    Acta Biochimica Polonica (rok: 2017, tom: 64, strony: 177-181), Wydawca: Polskie Towarzystwo Biochemiczne i Koitet Biochemii i Biofizyki PAN
    Status:
    Published
    DOI:
    10.18388/abp.2016-1419 - link to the publication
  10. Bezafibrate Upregulates Mitochondrial Biogenesis and Influence Neural Differentiation of Human-Induced Pluripotent Stem Cells
    Authors:
    Justyna Augustyniak & Jacek Lenart & Paweł Gaj & Monika Kolanowska & Krystian Jazdzewski & Piotr Pawel Stepien & Leonora Buzanska
    Academic press:
    Molecular Neurobiology (rok: 2018, tom: epub, strony: epub ahead of print), Wydawca: Springer Verlag
    Status:
    Published
    DOI:
    10.1007/s12035-018-1368-2 - link to the publication
  11. Controlling the mitochondrial antisense – role of the SUV3-PNPase complex and its co-factor GRSF1 in mitochondrial RNA surveillance
    Authors:
    Zbigniew Pietras, Magdalena A. Wojcik, Lukasz S. Borowski, Maciej Szewczyk, Tomasz M. Kulinski, Dominik Cysewski, Piotr P. Stepien, Andrzej Dziembowski & Roman J. Szczesny
    Academic press:
    Molecular & Cellular Oncology (rok: 2018, tom: 20, strony: 2372-3556), Wydawca: Taylor&Francis Group
    Status:
    Published
    DOI:
    10.1080/23723556.2018.1516452 - link to the publication
  12. Dialogi pomiędzy jądrem a mitochondriami
    Authors:
    Maciej Szewczyk, Piotr P. Stępień
    Academic press:
    Postępy Biochemii (rok: 2016, tom: 62 nr 2, strony: 158-161), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published