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A comparative evaluation of effectiveness of phosphorothioate and phosphodiester lysophosphatidylcholine analogues in regulation of diabetes mellitus-related processes - in vitro studies of glucose uptake modulation and new receptors activity.

2013/11/N/NZ5/00270

Keywords:

lysophosphatidylcholine phosphodiester and phosphorothioate analogues biological activity membrane receptors islets of Langerhans adipogenesis glicose uptake diabetes mellitus obesity

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ3_7: Signal transduction

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Politechnika Łódzka, Wydział Biotechnologii i Nauk o Żywności

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Anna Drzazga 

Number of co-investigators in the project: 2

Call: PRELUDIUM 6 - announced on 2013-09-16

Amount awarded: 99 580 PLN

Project start date (Y-m-d): 2014-08-04

Project end date (Y-m-d): 2017-02-03

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  1. Lysophosphatidylcholine and lysophosphatidylinosiol--novel promissing signaling molecules and their possible therapeutic activity.
    Authors:
    Drzazga, Anna; Sowinska, Agata; Koziolkiewicz, Maria
    Academic press:
    Acta poloniae pharmaceutica - drug research (rok: 2014, tom: 71(6), strony: 887-99), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Sulfur- and Acyl Chain-Dependent Influence of 2-Methoxy-Lysophosphatidylcholine Analogues on beta Pancreatic Cells
    Authors:
    Drzazga, Anna; Ciesielska, Anna; Gendaszewska-Darmach, Edyta
    Academic press:
    CURRENT TOPICS IN MEDICINAL CHEMISTRY (rok: 2015, tom: 15(23), strony: 2395-2405), Wydawca: Publisher BENTHAM SCIENCE PUBL LTD
    Status:
    Published
    DOI:
    10.2174/1568026615666150619141239 - link to the publication
  3. Lysophosphatidylcholine and its phosphorothioate analogues potentiate insulin secretion via GPR40 (FFAR1), GPR55 and GPR119 receptors in a different manner
    Authors:
    Drzazga A, Kristinsson H, Sałaga M, Zatorski H, Koziołkiewicz M, Gendaszewska-Darmach E, Bergsten P
    Academic press:
    MOLECULAR AND CELLULAR ENDOCRINOLOGY (rok: 2017, tom: S0303-7207(17), strony: 45300), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mce.2017.12.002 - link to the publication
  4. 2-OMe-lysophosphatidylcholine analogues are GPR119 ligands and activate insulin secretion from βTC-3 pancreatic cells: evaluation of structure-dependent biological activity
    Authors:
    Drzazga, Anna; Sowińska, Agata; Krzemińska, Agnieszka; Okruszek, Andrzej; Paneth, Piotr; Koziołkiewicz, Maria; Gendaszewska-Darmach, Edyta
    Academic press:
    BBA Molecular and Cell Biology of Lipids (rok: 2018, tom: 1863(1), strony: 91-103), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.004. - link to the publication
  5. Lysophosphatidylcholine elicits intracellular calcium signaling in a GPR55-dependent manner
    Authors:
    Drzazga A, Sowinska A, Krzeminska A, Rytczak P, Koziolkiewicz M, Gendaszewska-Darmach E
    Academic press:
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (rok: 2017, tom: 489(2), strony: 242-247), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2017.05.145. - link to the publication

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