Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

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Comprehensive transcriptomic and epigenomic analysis of the genetically-defined pigs predisposed to colorectal cancer.

2013/10/M/NZ2/00284

Keywords:

APC gene transcriptome epigenome NGS colorectal cancer pig

Descriptors:

  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ9_2: Animal production

Panel:

NZ2 - Genetics, genomics: molecular genetics, genomics, proteomics, bioinformatics, systems biology, genetic epidemiology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Medycyny Weterynaryjnej i Nauk o Zwierzętach

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marek Świtoński 

Number of co-investigators in the project: 10

Call: HARMONIA 5 - announced on 2013-06-14

Amount awarded: 1 254 240 PLN

Project start date (Y-m-d): 2014-06-06

Project end date (Y-m-d): 2017-10-05

Project duration:: 40 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (5)
  1. Altered microRNA profiles during early colon adenoma progression in a porcine model of familial adenomatouspolyposis
    Authors:
    Stachowiak M., Flisikowska T., Bauersachs S., Perleberg C., Pausch H., Switonski M., Kind A., Saur D., Schnieke A., Flisikowski K.
    Academic press:
    Oncotarget (rok: 2017, tom: 8 (56), strony: 96154-96160), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.21774 - link to the publication
  2. Germline gene polymorphisms predisposing domestic mammals to carcinogenesis
    Authors:
    Flisikowski K, Flisikowska T, Sikorska A, Perkowska A, Kind A, Schnieke A, Switonski M.
    Academic press:
    Veterinary and Comparative Oncology (rok: 2017, tom: 15(2), strony: 289-298), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/vco.12186 - link to the publication
  3. Elevated expression of p53 in early colon polyps in a pig model of human familial adenomatous polyposis
    Authors:
    Sikorska A., Flisikowska T., Stachowiak M., Kind A., Schnieke A., Flisikowski K, Switonski M.
    Academic press:
    Journal of Applied Genteics (rok: 2018, tom: 59, strony: 485-491), Wydawca: SPRINGER
    Status:
    Published
    DOI:
    10.1007/s13353-018-0461-6 - link to the publication
  4. The expression of TAP1 candidate gene, but not its polymorphism and methylation, is associated with colonic polyp formation in a porcine model of human familial adenomatous polyposis
    Authors:
    Perkowska A., Flisikowska T., Perleberg C., Flisikowski K., Stachowiak M., Nowacka-Woszuk J., Saur D., Kind A., Schnieke A., Switonski M.
    Academic press:
    Animal Biotechnology (rok: 2019, tom: online early, strony: online early), Wydawca: Taylor & Francis
    Status:
    Published
    DOI:
    10.1080/10495398.2019.1590377 - link to the publication
  5. Porcine FAP model enables systematic analysis of early events in adenoma progression
    Authors:
    Flisikowska T. , Stachowiak M. , Xu H. , Wagner A. , Hernández-Cáceres A. , Wurmser C. , Wander C. , Pausch H. , Fischer K., Perkowska A. , Frishman D., Fries R. , Switonski M. , Kind A. , Prof. Dieter Saur , Schnieke A., Flisikowski K.,
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 6613), Wydawca: SPRINGER-NATURE
    Status:
    Published
    DOI:
    10.1038/s41598-017-06741-8 - link to the publication
  1. Polymorphism of TP53 and CSF1R genes in genetically modified pigs at the APC locus
    Authors:
    Sikorska A., Flisikowska T., Flisikowski K., Kind A., Schnieke A., Świtoński M.
    Conference:
    V Polski Kongres Genetyki (rok: 2016, ), Wydawca: Polskie Towarzystwo Genetyczne
    Data:
    konferencja 19-22.09.2016
    Status:
    Published
  2. "Precancerous molecular features committing development of colonic polyps – studies with APC1311-targeted pigs"
    Authors:
    Flisikowski K., Flisikowska T., Dragan-Stachowiak M., Wander C., Wagner A., Wurmser Ch., Perkowska A., Bauersachs S., Kind A., Fries R., Świtoński M., Saur D., Schnieke A
    Conference:
    V Polski Kongres Genetyki (rok: 2016, ), Wydawca: Polskie Towarzystwo Genetyczne
    Data:
    konferencja 19-22.09.2016
    Status:
    Published
  3. Comparative sequence analysis of APC and TAP1 genes in genetically modified pig-models for human colorectal cancer
    Authors:
    Perkowska A., Flisikowska T., Flisikowski K., Kind A., Schnieke A., Świtoński M.
    Conference:
    V Polski Kongres Genetyki (rok: 2016, ), Wydawca: Polskie Towarzystwo Genetyczne
    Data:
    konferencja 19-22.09.2016
    Status:
    Published
  4. Poziom ekspresji wybranych genów u zmodyfikowanych genetycznie swiń APC1311 z różnym tempem rozwoju polipów w jelicie grubym
    Authors:
    Stachowiak M, Flisikowska T., Wender C., Perkowska A., Sikorska A., Kind A., Schnieke A., Flisikowski K., Switonski M.
    Conference:
    Zjazd Katedr Jednoimiennych Genetyki i Metod Hodowli Zwierząt (rok: 2017, ), Wydawca: Uniwersytet Przyrodniczy w Lublinie
    Data:
    konferencja 3 - 5 lipca
    Status:
    Published
  5. "Precancerous molecular features committing development of colonic polyps revealed by studies on the porcine model of human familial adenomatous polyposis"
    Authors:
    Flisikowska T., Wander C., Wagner A., Bruening F., Kind A., Flisikowski K., Schnieke A., Wurmser C., Fries R., Stachowiak M., Perkowska A., Switonski M., Bauersachs S., Saur D.
    Conference:
    35th International Society for Animal Genetics Conference (rok: 2016, ), Wydawca: International Society for Animal Genetics
    Data:
    konferencja 23.07.16 – 27.07.2016
    Status:
    Published