Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The studies on pharmacomodulation of oleanolic acid - new biogenic triterpene heterodimers

2013/09/B/NZ7/01279

Keywords:

triterpenes oleanolic acid antibiotics anticancer drugs polyphenols heterodimers triterpene conjugates pharmacomodulation

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • ST5_23:

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Medyczny im. Karola Marcinkowskiego w Poznaniu, Wydział Farmaceutyczny

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Lucjusz Zaprutko 

Number of co-investigators in the project: 6

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 492 120 PLN

Project start date (Y-m-d): 2014-03-21

Project end date (Y-m-d): 2016-06-20

Project duration:: 27 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wielozadaniowa stacja robocza do syntezy równoległej Star Fish (20 000 PLN)
  2. Rozbudowany system próżniowy (30 000 PLN)
  3. Multifunkcyjny reaktor MW-UV-US (75 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Hybrid compounds strategy in the synthesis of oleanolic skeleton-NSAID derivatives
    Authors:
    Anna Pawełczyk, Dorota Olender, Katarzyna Kasprzak-Sowa, Lucjusz Zaprutko
    Academic press:
    Molecules (rok: 2016, tom: 21, strony: 420), Wydawca: MDPI - Open Access Publishing
    Status:
    Published
    DOI:
    10.3390/molecules21040420 - link to the publication
  2. Molecular consortia - various structural and synthetic concepts for more effective therapeutics synthesis
    Authors:
    Anna Pawełczyk, Katarzyna Sowa-Kasprzak, Dorota Olender, Lucjusz Zaprutko
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 1104), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19041104 - link to the publication
  3. Strong and long-lasting antinociceptive and anti-inflammatory conjugate of naturally occurring oleanolic acid and aspirin
    Authors:
    Barbara Bednarczyk-Cwynar, Natalia Wachowiak, Michal Szulc, Ewa Kamińska, Anna Bogacz, Joanna Bartkowiak-Wieczorek, Lucjusz Zaprutko, Przemyslaw Lukasz Mikolajczak
    Academic press:
    Fronteirs of Pharmacology (rok: 2016, tom: 7, strony: Article 202), Wydawca: Frontiers Media S.A.
    Status:
    Published
    DOI:
    10.3389/fphar.2016.00202 - link to the publication
  4. Hybrids of oleanolic acid with norbornene-2,3-dicarboximide-N-carboxylic acids as potential anticancer agents
    Authors:
    Barbara Bednarczyk-Cwynar, Piotr Ruszkowski, Dmytro Atamanyuk, Roman Lesyk, Lucjusz Zaprutko
    Academic press:
    Acta Poloniae Pharmaceutica. Drug Research (rok: 2017, tom: 74, strony: No 3, 827-835), Wydawca: Polskie Towarzystwo Farmaceutyczne
    Status:
    Published
    DOI:
    brak - link to the publication

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