Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of assymetric dimethylarginine (ADMA) in hepathic encephalopathy: marker, mediator or modulator?

2013/09/B/NZ4/00536

Keywords:

hepatic encephalopathy ammonia assymetric dimethyarginine nitric oxide cerebral blood flow

Descriptors:

  • NZ7_15: Toxicology
  • NZ4_11: Metabolism
  • NZ4_7: Neurophysiology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Magdalena Zielińska 

Number of co-investigators in the project: 7

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 640 000 PLN

Project start date (Y-m-d): 2014-02-12

Project end date (Y-m-d): 2017-08-11

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Autosampler z funkcjami preparatyki próbek (70 000 PLN)

Information in the final report

  • Publication in academic press/journals (7)
  • Articles in post-conference publications (12)
  1. Asymmetric dimethylarginine and hepatic encephalopathy: cause, effect or association?
    Authors:
    Czarnecka A, Milewski K, Zielińska M
    Academic press:
    Neurochem Res (rok: 2017, tom: 42(3), strony: 750-761), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064-016-2111-x - link to the publication
  2. Cerebrovascular reactivity and cerebral perfusion of rats with acute liver failure: role of L-glutamine and asymmetric dimethylarginine in L-arginine-induced response.
    Authors:
    Czarnecka A, Aleksandrowicz M, Jasiński K, Jaźwiec R, Kalita K, Hilgier W, Zielińska M.
    Academic press:
    Journal of Neurochemistry (rok: 2018, tom: 147, strony: 692-704), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jnc.14578 - link to the publication
  3. The dimethylarginine (ADMA)/nitric oxide pathway in the brain and periphery of rats with thioacetamide-induced acute liver failure: modulation by histidine.
    Authors:
    Milewski K, Hilgier W, Albrecht J, Zielińska M.
    Academic press:
    Neurochemistry International (rok: 2015, tom: 88, strony: 26-31), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.neuint.2014.12.004. - link to the publication
  4. Carnosine Reduces Oxidative Stress and Reverses Attenuation of Righting and Postural Reflexes in Rats with Thioacetamide-Induced Liver Failure.
    Authors:
    Milewski K, Hilgier W, Fręśko I, Polowy R, Podsiadłowska A, Zołocińska E, Grymanowska AW, Filipkowski RK, Albrecht J, Zielińska M.
    Academic press:
    Neurochemical Research (rok: 2016, tom: 41(1), strony: 376-84), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s11064 - link to the publication
  5. Induction of inducible nitric oxide synthase expression in ammonia-exposed cultured astrocytes is coupled to increased arginine transport by upregulated y(+) LAT2 transporter.
    Authors:
    Zielińska M, Milewski K, Skowrońska M, Gajos A, Ziemińska E, Beręsewicz A, Albrecht J.
    Academic press:
    Journal of Neurochemistry (rok: 2015, tom: 135(6), strony: 1272-81), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1111/jnc.13387 - link to the publication
  6. Ammonia reduces intracellular asymmetric dimethylarginine in cultured astrocytes stimulating its y+LAT2 carrier- mediated loss
    Authors:
    Milewski K, Bogacińska-Karaś M, Fręśko I, Hilgier W, Jaźwiec R, Albrecht J, Zielińska M
    Academic press:
    International Journal of Molecular Sciences (rok: 2017, tom: 18(11), strony: 45304), Wydawca: MDPI AG (Basel, Switzerland)
    Status:
    Published
    DOI:
    10.3390/ijms18112308 - link to the publication
  7. Intracerebral administration of S-adenosylhomocysteine or S-adenosylmethionine attenuates the increases in the cortical extracellular levels of dimethylarginines without affecting cGMP level in rats with acute liver failure
    Authors:
    Czarnecka A, Milewski M, Jaźwiec R, Zielińska M
    Academic press:
    Neurotoxicity Research (rok: 2017, tom: 31(1), strony: 99-108), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12640-016-9668-7 - link to the publication
  1. "L-histidine administration increases brain carnosine concentration in rats with thioacetamide-induced acute liver failure: a contribution to increased antioxidant capacity (TAC)?"
    Authors:
    K. Milewski, W. Hilgier, J. Albrecht, M. Zielińska
    Conference:
    12th International Symposium: Molecular Basis of pathology and therapy in neurological disorders. (rok: 2014, ), Wydawca: Termedia Publishing House
    Data:
    konferencja 21-22 Listopad
    Status:
    Published
    DOI:
    link to the publication
  2. Contribution of the arginine/glutamine transporter y+LAT2 to astrocytic NO synthesis in hyperammonemia".
    Authors:
    M. Zielińska
    Conference:
    Krakow Conference – Glutamate/GABA and neuro-glia-vascular interplay in norm and pathology (rok: 2014, ), Wydawca: The Organizing Committee
    Data:
    konferencja 21-24 Maj
    Status:
    Published
    DOI:
    link to the publication
  3. "Ammonia reduces intracellular ADMA level in cultured astrocytes and endothelial cells: possible involvement of increased y+LAT2- mediated efflux."
    Authors:
    K. Milewski, J. Albrecht, W. Hilgier, M. Zielińska
    Conference:
    European Society for Neurochemistry's Conference Molecular Mechanisms of Regulation in the Nervous System (rok: 2015, ), Wydawca: The Organizing Committee
    Data:
    konferencja June 14-17
    Status:
    Published
    DOI:
    link to the publication
  4. Endothelial nitric oxide synthase (eNOS) uncoupling- dependent lowering of cerebral blood flow in prefrontal cortex of rats with acute liver failure
    Authors:
    Milewski K, Czarnecka A, Albrecht J, Zielińska M
    Conference:
    17 th International Society for Hepatic Encephalopathy and Nitrogen Metabolism (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja March 9-11
    Status:
    Published
    DOI:
    link to the publication
  5. L-arginine improves the diminished cerebral blood flow in rats with acute liver failure: uncertain role of asymmetric dimethylarginine
    Authors:
    Czarnecka A, Jasiński K, Jaźwiec R, Wojciech Hilgier W, Gajos-Draus A, Kalita K, Beręsewicz A, Zielińska M
    Conference:
    17 th International Society for Hepatic Encephalopathy and Nitrogen Metabolism (rok: 2017, ), Wydawca: Elsevier
    Data:
    konferencja March 9-11
    Status:
    Published
    DOI:
    link to the publication
  6. S-adenosylmethionine administration corrects the GSH/GSSG ratio in the cerebral cortex of rats with acute liver failure induced by thioacetamide
    Authors:
    Czarnecka A, Hilgier W, Zielińska M
    Conference:
    American Society for Neurochemistry (rok: 2017, ), Wydawca: Sage Jurnals
    Data:
    konferencja March 18-22
    Status:
    Published
    DOI:
    link to the publication
  7. "TNF alpha increases the activity of phosphate-activated glutaminase in ammonia-treated rat cortical astrocytes: Possible involvement of NMDA receptors"
    Authors:
    K. Milewski, O. Jarco, J. Albercht, M. Zielińska
    Conference:
    Krakow Conference – Glutamate/GABA and neuro-glia-vascular interplay in norm and pathology (rok: 2014, ), Wydawca: The Organizing Committee
    Data:
    konferencja 21-24 Maj
    Status:
    Published
    DOI:
    link to the publication
  8. "Effects of TNF-α and ammonia on the expression and activity of the kidney type glutaminase in rat cortical astrocytes: Possible involvement of NMDA receptors."
    Authors:
    K. Milewski, O. Jarco, J. Albercht, M. Zielińska
    Conference:
    ISHEN Conference (rok: 2014, ), Wydawca: The Organizing Committee
    Data:
    konferencja 11-13 Wrzesień
    Status:
    Published
    DOI:
    link to the publication
  9. "Diverse effects of histidine on ADMA/NO pathway in the brain and blood of rats with liver failure".
    Authors:
    K. Milewski, W. Hilgier, J. Albrecht, M. Zielińska
    Conference:
    ISHEN Conference (rok: 2014, ), Wydawca: The Organizing Committee
    Data:
    konferencja 11-13 Wrzesień
    Status:
    Published
    DOI:
    link to the publication
  10. "Brain extracellular levels of dimethylarginines (ADMA, SDMA) and cGMP and their modulation by exogenous S-adenosylmethionine in rats with acute liver failure".
    Authors:
    A. Czarnecka, J. Albrecht, M. Zielińska
    Conference:
    European Society for Neurochemistry's Conference Molecular Mechanisms of Regulation in the Nervous System (rok: 2015, ), Wydawca: The Organizing Committee
    Data:
    konferencja June 14-17
    Status:
    Published
    DOI:
    link to the publication
  11. Reduced cerebral blood flow in tioacetamide-induced hepatic encephalopathy in rats: an arterial spin labeling MRI study".
    Authors:
    A. Czarnecka, M. Zielińska
    Conference:
    XLV Polish Semminars of Nuclear Magnetic Rezonance (rok: 2014, ), Wydawca: The Organizing Committee
    Data:
    konferencja 1-2 Grudzień
    Status:
    Published
    DOI:
    link to the publication
  12. "Ammonia reduces intracellular ADMA concentration in cultured astrocytes and brain endothelial cells (RBE-4) via y+LAT2- mediated efflux."
    Authors:
    K. Milewski, J. Albrecht, W. Hilgier, M. Zielińska
    Conference:
    Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics. (rok: 2015, ), Wydawca: Termedia Publishing House
    Data:
    konferencja October 22-23
    Status:
    Published
    DOI:
    link to the publication

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