Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Studies on the role of lactoferrin in the regulation of disorders of the microflora and intestinal barrier function, based on animal models.

2013/09/B/NZ6/00849

Keywords:

lactoferrin sepsis infection translocation iron manganese

Descriptors:

  • NZ6_4: Bacteriology
  • NZ1_10: Microbiology
  • NZ6_1: Adaptive and innate immunity

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Magdalena Strus 

Number of co-investigators in the project: 11

Call: OPUS 5 - announced on 2013-03-15

Amount awarded: 512 300 PLN

Project start date (Y-m-d): 2014-03-03

Project end date (Y-m-d): 2017-12-02

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Czytnik absorbancji (30 000 PLN)
  2. Oprogramowanie do systemu obrazowania mikroskopowych preparatów fluorescencyjnych. (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (5)
  • Articles in post-conference publications (4)
  1. Mn3+-saturated bovine lactoferrin as a new complex with potential prebiotic activities for dysbiosis treatment and prevention – On the synthesis, chemical characterization and origin of biological activity
    Authors:
    Klaudyna Śpiewak, Grzegorz Majka, Magdalena Pilarczyk- Żurek, Paweł M. Nowak, Michał Woźniakiewicz, Piotr Pietrzyk, Tomasz Korzeniak, Anna Stochel-Gaudyn, Krzysztof Fyderek, Magdalena Strus, Małgorzata Brindell
    Academic press:
    Journal of Functional Foods (rok: 2017, tom: 38, strony: 264-272), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jff.2017.09.042 - link to the publication
  2. The dual role of Escherichia coli in the course of ulcerative colitis
    Authors:
    Magdalena Pilarczyk-Żurek, Magdalena Strus, Paweł Adamski, Piotr B. Heczko
    Academic press:
    BMC Gastroenterology (rok: 2016, tom: 16, strony: 128), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12876-016-0540-2 - link to the publication
  3. Lactoferrin – different effects on Gram-negative and Gram-positive bacteria depending on saturation with iron and manganese.
    Authors:
    Grzegorz Majka, Magdalena Pilarczyk-Żurek, Magdalena Strus
    Academic press:
    Biometals (tom: nd, strony: ), Wydawca: Springer Netherlands
    Status:
    Submitted
    DOI:
    brak - link to the publication
  4. The impact of lactoferrin with different levels of metal saturation on the intestinal epithelial barrier function and mucosal inflammation
    Authors:
    Grzegorz Majka, Grażyna Więcek, Małgorzata Śróttek, Klaudyna Śpiewak, Małgorzata Brindell, Joanna Koziel, Janusz Marcinkiewicz, Magdalena Strus
    Academic press:
    Biometals (rok: 2016, tom: 29(6), strony: 1019-1033), Wydawca: Springer Netherlands
    Status:
    Published
    DOI:
    10.1007/s10534-016-9973-x - link to the publication
  5. Bioinorganic antimicrobial strategies in the resistance era
    Authors:
    Anna Regiel-Futyra, Janusz M. Dąbrowski, Olga Mazuryk, Klaudyna Śpiewak, Agnieszka Kyzioł, Barbara Pucelik, Małgorzata Brindell, Grażyna Stochel
    Academic press:
    Coordination Chemistry Reviews (rok: 2017, tom: 351, strony: 76-117), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ccr.2017.05.005 - link to the publication
  1. Effect of Manganese-Saturated Lactoferrin on the Population Numbers of Lactobacillus Strains
    Authors:
    G. Majka, M. Pilarczyk-Żurek, M. Strus
    Conference:
    International Scientific Conference: Probiotics and Prebiotics (rok: 2017, ), Wydawca: bd.
    Data:
    konferencja 20-22.6
    Status:
    Published
  2. Effect of manganese-saturated lactoferrin on the population numbers of Lactobacillus strain
    Authors:
    G. Majka, M. Pilarczyk-Żurek, M. Strus
    Conference:
    XIII International Conference on Lactoferrin Structure, Function & Applications (rok: 2017, ), Wydawca: bd.
    Data:
    konferencja 5-10.11
    Status:
    Published
  3. Effect of manganese-saturated lactoferrin on the population numbers of probiotic bacteria
    Authors:
    M. Pilarczyk-Zurek, G. Majka, J. Domagała, M. Strus
    Conference:
    9th Probiotic, Prebiotic & New Foods, Nutraceuticals and Botanicals (rok: 2017, ), Wydawca: bd.
    Data:
    konferencja 10-12.9
    Status:
    Published
    DOI:
    link to the publication
  4. Patomechanizmy translokacji bakteryjnej i związanej z nią sepsy w oparciu o badania w modelu szczurzym
    Authors:
    G. Majka, M. Pilarczyk-Żurek, A. Baranowska, B. Skowron, M. Strus
    Conference:
    V Ogólnopolska Konferencja "Zwierzęta w badaniach naukowych" (rok: 2017, ), Wydawca: bd.
    Data:
    konferencja 11-13.9
    Status:
    Published

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