Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Combined stem cell-based and gene therapy as a novel strategy to protect photoreceptors - evaluation of renewal mechanisms in retinal degenerations.

2012/07/B/NZ5/02498

Keywords:

retinitis pigmentosa stem and progenitor cells neurotrophic factors

Descriptors:

  • NZ5_3: Pathogenesis of human diseases
  • NZ5_9: Other related subjects

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Pomorski Uniwersytet Medyczny w Szczecinie, Wydział Lekarski z Oddziałem Nauczania w Języku Angielskim

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Bogusław Machaliński 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 477 000 PLN

Project start date (Y-m-d): 2013-06-13

Project end date (Y-m-d): 2017-06-12

Project duration:: 48 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do przyżyciowej analizy dna oka i detekcji fluorescencji - fundus camera. (100 000 PLN)
  2. Mikroskop z zestawem obiektywów.
  3. Urządzenie dedykowane do analizy globalnej ekspresji genów (35 681 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  1. Preclinical Evaluation of Long-Term Neuroprotective Effects of BDNF-Engineered Mesenchymal Stromal Cells as Intravitreal Therapy for Chronic Retinal Degeneration in Rd6 Mutant Mice
    Authors:
    Renata Lejkowska, Miłosz Piotr Kawa, Ewa Pius-Sadowska, Dorota Rogińska, Karolina Łuczkowska, Bogusław Machaliński and Anna Machalińska
    Academic press:
    International Journal of Molecular Sciences (rok: 2019, tom: 20(3), strony: 777), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20030777 - link to the publication
  2. Neuroprotective and Antiapoptotic Activity of Lineage-Negative Bone Marrow Cells after Intravitreal Injection in a Mouse Model of Acute Retinal Injury
    Authors:
    Anna Machalińska,Dorota Rogińska,Ewa Pius-Sadowska,MiBosz P. Kawa,Edyta Paczkowska,Michał Rudnicki, Renata Lejkowska,Bartłomiej Baumert,Barbara Wiszniewska, Bogusław Machaliński
    Academic press:
    Stem Cells International (rok: 2015, tom: Volume 2015, strony: 45308), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2015/620364 - link to the publication
  3. The influence of BDNF on human umbilical cord blood stem/ progenitor cells: Implications for stem cell-based therapy of neurodegenerative disorders
    Authors:
    Edyta Paczkowska, Karolina Łuczkowska, Katarzyna Piecyk, Dorota Rogińska, Ewa Pius-Sadowska, Przemysław Ustianowski, Elżbieta Cecerska, Barbara Dołęgowska, Zbigniew Celewicz, and Bogusław Machaliński
    Academic press:
    Acta Neurobiologiae Experimentalis (rok: 2015, tom: 75, strony: 172-191), Wydawca: Polish Neuroscience Society
    Status:
    Published
    DOI:
    brak - link to the publication

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