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Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Interaction of a potential anticancer agent, 3-bromopyruvic acid, with normal and malignant cells

2012/07/B/NZ7/03618

Keywords:

3-bromopyruvate transport glycolysis oxidative stress

Descriptors:

  • NZ7_14: Pharmacy, pharmacotherapy, pharmacology
  • NZ7_15: Toxicology
  • NZ5_7: Human disease treatment

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Uniwersytet Rzeszowski, Wydział Biologiczno-Rolniczy

woj. podkarpackie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Grzegorz Bartosz 

Number of co-investigators in the project: 6

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 476 800 PLN

Project start date (Y-m-d): 2013-07-15

Project end date (Y-m-d): 2016-07-14

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2 z regulowanym dopływem tlenu (70 000 PLN)
  2. Mikroskop z odwróconą optyką (30 000 PLN)

Information in the final report

  • Publication in academic press/journals (6)
  1. Anticancer agent 3-bromopyruvic acid forms a conjugate with glutathione
    Authors:
    Sadowska-Bartosz I, Szewczyk R, Jaremko L, Jaremko M, Bartosz G.
    Academic press:
    Pharmacological Reports (rok: 2016, tom: 68, strony: 502-505), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.11.007 - link to the publication
  2. Effect of 3-bromopyruvate acid on the redox equilibrium in non-invasive MCF-7 and invasive MDA-MB-231 breast cancer cells
    Authors:
    Kwiatkowska E, Wojtala M, Gajewska A, Soszyński M, Bartosz G, Sadowska-Bartosz I.
    Academic press:
    Journal of Bioenergetics and Biomembranes (rok: 2016, tom: 48, strony: 23-32), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10863-015-9637-5 - link to the publication
  3. Transport of 3-bromopyruvate across the human erythrocyte membrane
    Authors:
    Sadowska-Bartosz I, Soszyński M, Ułaszewski S, Ko Y, Bartosz G.
    Academic press:
    Cellular and Molecular Biology Letters (rok: 2014, tom: 19, strony: 201-214), Wydawca: De Gruyter
    Status:
    Published
    DOI:
    10.2478/s11658-014-0189-1 - link to the publication
  4. 3-Bromopyruvate induces expression of antioxidant genes
    Authors:
    Łukasz Pułaski, Izabela Jatczak-Pawlik, Marta Sobalska-Kwapis, Dominik Strapagiel, Grzegorz Bartosz, Izabela Sadowska-Bartosz
    Academic press:
    PLoS One (rok: 2018, tom: brak, strony: brak), Wydawca: (Public Library of Science
    Status:
    Submitted
    DOI:
    brak - link to the publication
  5. ABCB1-overexpressing MDCK-II cells are hypersensitive to 3-bromopyruvic acid
    Authors:
    Sadowska-Bartosz I, Grębowski J, Kępka E, Studzian M, Bartosz G, Pulaski L
    Academic press:
    Life Sciences (rok: 2016, tom: 162, strony: 138-144), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.lfs.2016.08.012 - link to the publication
  6. Effect of 3-bromopyruvic acid on human erythrocyte antioxidant defense system
    Authors:
    Sadowska-Bartosz I, Bartosz G.
    Academic press:
    Cell Biology International (rok: 2013, tom: 37, strony: 1285-1290), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/cbin.10160 - link to the publication

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