Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Quantitative analysis of DNA cleavage by restriction enzymes in a crowded environment using fluorescence correlation spectroscopy

2012/07/D/ST4/02183

Keywords:

Fluorescence correlation spectroscopy crowded enviroment DNA cleavage

Descriptors:

  • ST4_13: Solid-state chemistry, surface physicochemistry
  • ST4_1: Physical chemistry, chemical physics
  • ST4_6: Instrumental methods in chemistry

Panel:

ST4 - Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution :

Instytut Chemii Fizycznej PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Sen Hou 

Number of co-investigators in the project: 2

Call: SONATA 4 - announced on 2012-09-15

Amount awarded: 499 250 PLN

Project start date (Y-m-d): 2013-06-27

Project end date (Y-m-d): 2016-12-26

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Aparat do elektroforezy białek (8 000 PLN)
  2. Kołyska laboratoryjna do odbarwiania żeli (1 000 PLN)
  3. System do obrazowania żeli (49 000 PLN)
  4. Termostat z chłodzeniem (9 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Motion of nanoprobes in complex liquids within the framework of the length-scale dependent viscosity model
    Authors:
    Tomasz Kalwarczyk, Krzysztof Sozanski, Anna Ochab-Marcinek, Jedrzej Szymanski, Marcin Tabaka, Sen Hou, Robert Holyst
    Academic press:
    Advances in Colloids and Interface Science (rok: 2015, tom: 223, strony: 55–63), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.cis.2015.06.007 - link to the publication
  2. A flexible fluorescence correlation spectroscopy based method for quantification of the DNA double labeling efficiency with precision control
    Authors:
    Hou, S ; Tabaka, M ; Sun, LL ; Trochimczyk, P ; Kaminski, TS ; Kalwarczyk, T ; Zhang, X ; Holyst, R
    Academic press:
    Laser Physics Letters (rok: 2014, tom: 11, strony: 85602), Wydawca: IOP Science
    Status:
    Published
    DOI:
    10.1088/1612-2011/11/8/085602 - link to the publication
  3. How can macromolecular crowding inhibit biological reactions? The enhanced formation of DNA nanoparticles
    Authors:
    Sen Hou, Piotr Trochimczyk, Lili Sun, Agnieszka Wisniewska, Tomasz Kalwarczyk, Xuzhu Zhang, Beata Wielgus-Kutrowska, Agnieszka Bzowska, Robert Holyst1
    Academic press:
    Scientific Reports (rok: 2016, tom: 6, strony: 22033, 1-11), Wydawca: nature publishing group
    Status:
    Published
    DOI:
    10.1038/srep22033 - link to the publication
  4. The hinge region strengthens the nonspecific interaction between Lac- repressor and DNA: a computer simulation study
    Authors:
    Lili Sun, Marcin Tabaka, Sen Hou, Lin Li, Krzysztof Burdzy, Aleksei Aksimentiev, Christopher Maffeo, Xuzhu Zhang, Robert Holyst
    Academic press:
    Plos One (rok: 2016, tom: 11, strony: e0152002 (1-12)), Wydawca: PUBLIC LIBRARY SCIENCE
    Status:
    Published
    DOI:
    10.1371/journal.pone.0152002 - link to the publication

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