Projects funded by the NCN
New methods for the stereoselective synthesis of cyclolignans of potencial cytostatic and antiviral activity.
2012/07/B/ST5/02476
Keywords:
cyclolignans stereoselective synthesis fulgides podophyllotoxin chiral auxiliary prolinol
Descriptors:
- ST5_23:
Panel:
ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering
Host institution :
Uniwersytet Warszawski, Wydział Chemii
woj. mazowieckie
Principal investigator (from the host institution):
Number of co-investigators in the project: 4
Call: OPUS 4 - announced on 2012-09-15
Amount awarded: 395 000 PLN
Project start date (Y-m-d): 2013-06-28
Project end date (Y-m-d): 2016-06-27
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Waga analityczna (2 sztuki).
- Naczynie Dewara na ciekły azot wraz z zaworem i dyszą do pobierania ciekłego azotu (6 000 PLN)
- Pompa próżniowa olejowa z miernikiem próżni (20 000 PLN)
- Linia próżniowo-argonowa z wymrażaczem i bublerem (11 000 PLN)
- Pompa próżniowa, membranowa z kontrolerem próżni (18 000 PLN)
Information in the final report
- Publication in academic press/journals (3)
- Unusual visible-light photolytic cleavage of tertiary amides during the synthesis of cyclolignans related to podophyllotoxinAuthors:Kamil Lisiecki, Krzysztof K. Krawczyk, Piotr Roszkowski, Jan K. Maurin, Armand Budzianowski, Zbigniew CzarnockiAcademic press:Tetrahedron (rok: 2017, tom: 27, strony: 6316-6328), Wydawca: ElsevierStatus:PublishedDOI:10.1016/j.tet.2017.09.021 - link to the publication
- Flow Photochemistry as a Tool for the Total Synthesis of (+)-EpigalcatinAuthors:Kamil Lisiecki, Zbigniew CzarnockiAcademic press:Organic Letters (rok: 2018, ), Wydawca: American Chemical SocietyStatus:Accepted for publicationDOI:10.1021/acs.orglett.7b03974 - link to the publication
- Formal synthesis of (−)-podophyllotoxin through the photocyclization of an axially chiral 3,4-bisbenzylidene succinate amide ester – a flow photochemistry approachAuthors:Kamil Lisiecki, Krzysztof Krawczyk, Piotr Roszkowski, Jan K. Maurin, Zbigniew CzarnockiAcademic press:Organic & Biomolecular Chemistry (rok: 2016, tom: 14, strony: 460-469), Wydawca: Royal Society of ChemistryStatus:PublishedDOI:10.1039/c5ob01844g - link to the publication