Projects funded by the NCN
Identification of the APOBEC3 cytidine deaminases as an additional human defense system against RNA viruses, on the example of coronaviruses.
2012/07/N/NZ6/02955
Keywords:
the APOBEC3 cytidine deaminases human coronavirus NL63 innate immunity
Descriptors:
- NZ6_1: Adaptive and innate immunity
- NZ6_5: Virology
Panel:
NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology
Host institution :
UNIWERSYTET JAGIELLOŃSKI, Wydział Biochemii, Biofizyki i Biotechnologii
woj. małopolskie
Principal investigator (from the host institution):
Number of co-investigators in the project: 2
Call: PRELUDIUM 4 - announced on 2012-09-15
Amount awarded: 149 987 PLN
Project start date (Y-m-d): 2013-08-09
Project end date (Y-m-d): 2016-08-08
Project duration:: 36 months (the same as in the proposal)
Project status: Project settled
Equipment purchased [PL]
- Zestaw zaawansowanych pipet jednokanałowych Eppedorf Research plus. (7 000 PLN)
Information in the final report
- Publication in academic press/journals (4)
- APOBEC3-mediated restriction of RNA virus replicationAuthors:Aleksandra Milewska, Eveline Kindler, Philip Vkovski, Slawomir Zeglen, Marek Ochman, Volker Thiel, Zenon Rajfur, Krzysztof PyrcAcademic press:Scientific Reports (rok: 2018, tom: 13;8(1), strony: 5960), Wydawca: Nature Publishing GroupStatus:PublishedDOI:10.1038/s41598-018-24448-2 - link to the publication
- Entry of human coronavirus NL63 into the cell.Authors:Aleksandra Milewska, Paulina Nowak, Katarzyna Owczarek, Artur Szczepanski, Miroslaw Zarebski, Agnieszka Hoang, Krzysztof Berniak, Jacek Wojarski, Slawomir Zeglen, Zbigniew Baster, Zenon Rajfur, Krzysztof PyrcAcademic press:Journal of Virology (rok: 2018, tom: 17;92(3), strony: pii: e01933-17), Wydawca: American Society for MicrobiologyStatus:PublishedDOI:10.1128/JVI.01933-17 - link to the publication
- HTCC: Broad Range Inhibitor of Coronavirus EntryAuthors:Aleksandra Milewska, Kamil Kaminski, Justyna Ciejka, Katarzyna Kosowicz, Slawomir Zeglen, Jacek Wojarski, Maria Nowakowska, Krzysztof Szczubiałka , Krzysztof PyrcAcademic press:PLOS ONE (rok: 2016, tom: 11(6), strony: e0156552), Wydawca: Public Library of ScienceStatus:PublishedDOI:10.1371/journal.pone.0156552 - link to the publication
- Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.Authors:Aleksandra Milewska, Miroslaw Zarebski, Paulina Nowak, Karol Stozek, Jan Potempa, Krzysztof PyrcAcademic press:Journal of Virology (rok: 2014, tom: 88(22), strony: 13221-13230), Wydawca: American Society for MicrobiologyStatus:PublishedDOI:10.1128/JVI.02078-14 - link to the publication