Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

STAT1 and IRF8-mediated signal integration between IFNgamma and TLRs: a pathophysiological role in vascular diease

2012/07/B/NZ1/02710

Keywords:

IFNgamma TLR STAT1 IRF8 signal integration Vascular Disease

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_9: Biotechnology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Biologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Johannes Bluijssen (Bluyssen) 

Number of co-investigators in the project: 6

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 515 000 PLN

Project start date (Y-m-d): 2013-07-11

Project end date (Y-m-d): 2016-07-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Automatyczny licznik i analizator komórek. Pozwala na bardzo dokładną ocenę ilości i jakości komórek, ich zdrowia, rozmiaru. (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (9)
  1. STAT1 AND IRF8 IN VASCULAR INFLAMMATION AND CARDIOVASCULAR DISEASE: Diagnostic and therapeutic potential.
    Authors:
    Chmielewski S, Piaszyk-Borychowska A, Wesoły J and Bluyssen HA
    Academic press:
    International reviews of immunology (rok: 2015, tom: 25, strony: 45312), Wydawca: Taylor & Francis Group
    Status:
    Published
    DOI:
    10.3109/08830185.2015.1087519 - link to the publication
  2. Data mining of atherosclerotic plaque transcriptomes predicts STAT1-dependent inflammatory signal integration in vascular disease.
    Authors:
    Sikorski K, Wesoly J, Bluyssen HA.
    Academic press:
    Int J Mol Sci. (rok: 2014, tom: 15(8), strony: 14313-31), Wydawca: MDPI AG, Basel, Switzerland
    Status:
    Published
    DOI:
    10.3390/ijms150814313 - link to the publication
  3. STAT1-dependent signal integration between IFNgamma and TLR4 in vascular cells reflect pro-atherogenic responses in human atherosclerosis
    Authors:
    41.Stefan Chmielewski, Adam Olejnik, Krzysztof Sikorski, Jaroslav Pelisek, Hanna Nowicka, Alma Zernecke, Uwe Heemann, Joanna Wesoly, Marcus Baumann, Hans A.R. Bluyssen
    Academic press:
    PloS ONE (rok: 2014, tom: 9(12), strony: e113318), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0113318 - link to the publication
  4. CAVS - NOVEL IN SILICO SELECTION STRATEGY OF SPECIFIC STAT INHIBITORY COMPOUNDS
    Authors:
    48.Anna Czerwoniec; Malgorzata Szelag; Kajetan Juszczak; Joanna Wesoly; Hans A.R. Bluyssen
    Academic press:
    Journal of Computational Science. (rok: 2015, tom: 10, strony: 186-194), Wydawca: Elsevier B.V.
    Status:
    Published
    DOI:
    10.1016/j.jocs.2015.03.001 - link to the publication
  5. Identification of STAT1 and STAT3 specific inhibitors using comparative virtual screening and docking validation
    Authors:
    Malgorzata Szelag; Anna Czerwoniec; Joanna Wesoly; Hans Bluyssen.
    Academic press:
    PLoS ONE (rok: 2015, tom: 10(2), strony: e0116688), Wydawca: Plos
    Status:
    Published
    DOI:
    10.1371/journal.pone.0116688. - link to the publication
  6. Targeted inhibition of STATs and IRFs as a potential treatment strategy in cardiovascular disease.
    Authors:
    Malgorzata Szelag, Anna Piaszyk-Borychowska, Martyna Plen-Galaska, Joanna Wesoly and Hans A.R. Bluyssen
    Academic press:
    Oncotarget (rok: 2016, tom: 7, strony: 48788-48812), Wydawca: Impact Journals
    Status:
    Published
    DOI:
    10.18632/oncotarget.9195 - link to the publication
  7. Advances in peptidic and peptidomimetic-based approaches to inhibit STAT signaling in human diseases
    Authors:
    Malgorzata Szelag, Joanna Wesoly and Hans A.R. Bluyssen
    Academic press:
    Current Protein & Peptide Science (rok: 2016, tom: 17(2), strony: 135-46), Wydawca: Bentham Science Publishers
    Status:
    Published
    DOI:
    10.2174/1389203716666151102103706 - link to the publication
  8. Comparative screening and validation as a novel tool to identify STAT-specific inhibitors
    Authors:
    Malgorzata Szelag; Anna Czerwoniec; Joanna Wesoly; Hans Bluyssen.
    Academic press:
    Eur J Pharmacology (rok: 2014, tom: 740, strony: 417-20), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ejphar.2014.05.047 - link to the publication
  9. STAT2/IRF9-mediated IFNα signaling directs ISGF3-dependent and –independent transcription and antiviral activity without STAT1.
    Authors:
    Katarzyna Blaszczyk, Adam Olejnik, Yi-Ling Chen, Stefan Chmielewski, Kaja Kostyrko, Hanna Nowicka, Joanna Wesoly, Chien-Kuo Lee and Hans A.R. Bluyssen.
    Academic press:
    Biochem J. (rok: 2015, tom: 466(3), strony: 511-24), Wydawca: Portland Press
    Status:
    Published
    DOI:
    10.1042/BJ20140644. - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy