Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Antibacterial and immunomodulatory activities of novel ceragenins and their potential in treatment of local infections.

2012/07/B/NZ6/03504

Keywords:

ceragenins bacteria immunomodulatory activity

Descriptors:

  • NZ6_4: Bacteriology
  • NZ6_8: Other related subjects

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Medyczny w Białymstoku, Wydział Lekarski z Oddziałem Stomatologii i Oddziałem Nauczania w Języku Angielskim

woj. podlaskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Robert Bucki 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 606 090 PLN

Project start date (Y-m-d): 2013-10-21

Project end date (Y-m-d): 2016-10-20

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Tensytometr (MicroTroughXS, Kibron, Finland) (61 000 PLN)

Information in the final report

  • Publication in academic press/journals (14)
  • Articles in post-conference publications (12)
  1. Sporicidal activity of ceragenin CSA-13 against Bacillus subtilis.
    Authors:
    Ewelina Piktel, Katarzyna Pogoda, Maciej Roman, Katarzyna Niemirowicz, Grażyna Tokajuk, Marta Wróblewska, Beata Szynaka, Wojciech M Kwiatek, Paul B. Savage, Robert Bucki.
    Academic press:
    Scientific Reports (rok: 2017, tom: 7, strony: 45303), Wydawca: Nature
    Status:
    Published
    DOI:
    10.1038/srep44452 - link to the publication
  2. Stiffening of bacteria cells as a first manifestation of bactericidal attack.
    Authors:
    Katarzyna Pogoda, Ewelina Piktel, Piotr Deptuła, Paul B. Savage, Małgorzata Lekka, Robert Bucki.
    Academic press:
    Micron (rok: 2017, tom: 101, strony: 95-102), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.micron.2017.06.011 - link to the publication
  3. Bactericidal activity and biocompatibility of ceragenin CSA-13-coated magnetic nanoparticles.
    Authors:
    Katarzyna Niemirowicz, Urszula Surel, Agnieszka Z. Wilczewska, Joanna Mystkowska, Ewelina Piktel, Zbigniew Namiot, Alina Kułakowska, Paul B. Savage, Robert Bucki
    Academic press:
    Journal of Nanobiotechnology (rok: 2015, tom: 0,563888888888889, strony: 45302), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12951-015-0093-5. - link to the publication
  4. Core–shell magnetic nanoparticles display synergistic antibacterial effects against Pseudomonas aeruginosa and Staphylococcus aureus when combined with cathelicidin LL-37 or selected ceragenins
    Authors:
    Katarzyna Niemirowicz, Ewelina Piktel, Agnieszka Z Wilczewska, Karolina H Markiewicz, Bonita Durnaś, Marzena Wątek, Irena Puszkarz, Marta Wróblewska, Wiesława Niklińska, Paul B Savage, Robert Bucki
    Academic press:
    International Journal of Nanomedicine (rok: 2016, tom: 11, strony: 5443-5455), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S113706 - link to the publication
  5. Polyelectrolytes-mediated increase of pathogens biofilm formation.
    Authors:
    Robert Bucki, Katarzyna Niemirowicz, Urszula Wnorowska, Marzena Wątek, Fitzroy J. Byfield, Katrina Cruz, Marta Wróblewska, Paul A. Janmey
    Academic press:
    BMC Microbiology (rok: 2015, tom: 0,70625, strony: 45301), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12866-015-0457-x. - link to the publication
  6. Synthesis and structure–activity relationships of novel cationic lipids with anti-inflammatory and antimicrobial activities
    Authors:
    Melissa Myint, Robert Bucki, Paul A. Janmey, Scott L. Diamond
    Academic press:
    Bioorganic & Medicinal Chemistry Letters (rok: 2015, tom: 25, strony: 2837–2843), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bmcl.2015.04.104. - link to the publication
  7. Growth arrest and rapid capture of select pathogens following magnetic nanoparticle treatment.
    Authors:
    Katarzyna Niemirowicz , Izabela Swiecicka , Agnieszka Z. Wilczewska, Karolina H. Markiewicz , Urszula Surel , Alina Kulakowska , Zbigniew Namiot , Beata Szynaka , Robert Bucki , Halina Car
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2015, tom: 131, strony: 29-38), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2015.04.016. - link to the publication
  8. Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer DLD-1 cells.
    Authors:
    Katarzyna Niemirowicz, Izabela Prokop, Agnieszka Z. Wilczewska, Urszula Wnorowska, Ewelina Piktel, Marzena Wątek, Paul B. Savage, Robert Bucki.
    Academic press:
    International Journal of Nanomedicine (rok: 2015, tom: 10, strony: 3843-3853), Wydawca: Dove Medical Press
    Status:
    Published
    DOI:
    10.2147/IJN.S76104. - link to the publication
  9. Anaerobic bacteria growth in the presence of cathelicidin LL-37 and selected ceragenins delivered as magnetic nanoparticles cargo.
    Authors:
    Bonita Durnaś, Ewelina Piktel S.D., Marzena Wątek, Tomasz Wollny, Stanisław Góźdź, Jolanta Smok-Kalwat, Katarzyna Niemirowicz, Paul B. Savage, Robert Bucki.
    Academic press:
    BMC Microbiology (rok: 2017, tom: 17, strony: 45302), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s12866-017-1075-6 - link to the publication
  10. Bactericidal activity of cathelicidin LL-37 and select cationic lipids against hypervirulent strain of P. aeruginosa LESB58.
    Authors:
    Urszula Wnorowska, Katarzyna Niemirowicz, Melissa Myint, Scott Diamond, Marta Wróblewska, Paul B. Savage, Paul A. Janmey, Robert Bucki.
    Academic press:
    Antimicrobial Agents and Chemotherapy (rok: 2015, tom: 59, strony: 3808-3815), Wydawca: Ameriac Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/AAC.00421-15. - link to the publication
  11. Bactericidal Activity of Ceragenin CSA-13 in Cell Culture and in an Animal Model of Peritoneal Infection.
    Authors:
    Robert Bucki, Katarzyna Niemirowicz, Urszula Wnorowska, Fitzroy J. Byfield, Ewelina Piktel, Marzena Wątek, Paul A. Janmey, Paul B. Savage.
    Academic press:
    Antimicrobial Agents and Chemotherapy (rok: 2015, tom: 59, strony: 6274-6282), Wydawca: Ameriac Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/AAC.00653-15. - link to the publication
  12. Candidacidal Activity of Selected Ceragenins and Human Cathelicidin LL-37 in Experimental Settings Mimicking Infection Sites
    Authors:
    Bonita Durnaś, Urszula Wnorowska, Katarzyna Pogoda, Piotr Deptuła, Marzena Wątek, Ewelina Piktel, Stanisław Głuszek, Xiaobo Gu, Paul B. Savage, Katarzyna Niemirowicz, Robert Bucki
    Academic press:
    PLoS ONE (rok: 2016, tom: 11, strony: 45311), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0157242 - link to the publication
  13. Magnetic nanoparticles as a drug delivery system that enhance fungicidal activity of polyene antibiotics.
    Authors:
    Katarzyna Niemirowicz, Bonita Durnaś, Grażyna Tokajuk, Katarzyna Głuszek, Agnieszka Z. Wilczewska, Iwona Misztalewska, Joanna Mystkowska, Grzegorz Michalak, Anna Sodo, Marzena Wątek, Bożena Kiziewicz, Stanisław Góźdź, Stanisław Głuszek, Robert Bucki
    Academic press:
    Nanomedicine: Nanotechnology, Biology, and Medicine (rok: 2016, tom: 12, strony: 2395-2404), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nano.2016.07.006. - link to the publication
  14. The search for new sporicidal agents for medical use: where are we?
    Authors:
    Ewelina Piktel, Katarzyna Pogoda, Paul B Savage, Robert Bucki
    Academic press:
    Future Microbiology (rok: 2017, tom: 12, strony: 735-737), Wydawca: Future Medicine
    Status:
    Published
    DOI:
    10.2217/fmb-2017-0069 - link to the publication

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