Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Inducible pluripotent stem cells as a tool in articular cartilage regeneration.

2012/07/E/NZ3/01819

Keywords:

inducible pluripotent stem cells chondrocytes articular cartilage regenerative medicin

Descriptors:

  • NZ3_8: Stem cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Wielkopolskie Centrum Onkologii

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Wiktoria Suchorska 

Number of co-investigators in the project: 6

Call: SONATA BIS 2 - announced on 2012-09-15

Amount awarded: 1 475 850 PLN

Project start date (Y-m-d): 2013-08-21

Project end date (Y-m-d): 2019-08-20

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komora z laminarnym przepływem powietrza (55 000 PLN)
  2. System regałów klatkowych (12 szt.) (5 400 PLN)
  3. Zestaw kaset do analizy RNA w aparacie Agilent Bioanalizer (5 szt.) (24 000 PLN)
  4. Zestaw pipet automatycznych. (5 szt.) (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (21)
  1. Chondrogenic differentiation in vitro of hiPSCs activates pathways engaged in limb development.
    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Stem Cell Res. (rok: 2018, tom: 30, strony: 53-60), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2018.05.006 - link to the publication
  2. Comparison of four protocols to generate chondrocyte-like cells from human induced pluripotent stem cells (hiPSCs)
    Authors:
    Augustyniak E, Suchorska WM, Richter M, Trzeciak T,
    Academic press:
    Stem Cell Rev (rok: 2017, tom: 13, strony: 299-308), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s12015-016-9708-y - link to the publication
  3. Correlations between serum adipocytokine concentrations, disease stage, radiological status and total body fat content in the patients with primary knee osteoarthritis
    Authors:
    Magdalena Richter, Tomasz Trzeciak, Jakub Dalibor Rybka, Wiktoria Suchorska, Ewelina Augustyniak, Michał Lach, Małgorzata Kaczmarek, Jacek Kaczmarczyk
    Academic press:
    International Orthopaedics (rok: 2017, tom: 41, strony: 983-989), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00264-016-3370-5 - link to the publication
  4. Directed differentiation of induced pluripotent stem cells into chondrogenic lineages for articular cartilage treatment
    Authors:
    Lach M., Trzeciak T., Richter M., Pawlicz J., Suchorska W.
    Academic press:
    Journal of Tissue Engineering (rok: 2014, tom: vol. 5, strony: 45300), Wydawca: SAGE
    Status:
    Published
    DOI:
    10.1177/2041731414552701 - link to the publication
  5. Liquid Biopsy in Oligometastatic Prostate Cancer-A Biologist's Point of View.
    Authors:
    Stelcer E, Konkol M, Głȩboka A, Suchorska WM.
    Academic press:
    Front Oncol. (rok: 2019, tom: Aug 14;9:775, strony: 45310), Wydawca: Frontiers
    Status:
    Published
    DOI:
    10.3389/fonc.2019.00775 - link to the publication
  6. Application of cell and biomaterial-based tissue engineering methods in the treatment of cartilage, menisci and ligament injuries.
    Authors:
    Trzeciak T, Richter M, Suchorska W, Augustyniak E, Lach M, Kaczmarek M, Kaczmarczyk J
    Academic press:
    Int Orthop. (rok: 2016, tom: 40(3), strony: 615-24), Wydawca: Springer Links
    Status:
    Published
    DOI:
    10.1007/s00264-015-3099-6. - link to the publication
  7. Forced differentiation in vitro leads to stress-induced activation of DNA damage response in hiPSC-derived chondrocyte-like cells.
    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Plos One (rok: 2018, tom: 13(6), strony: 45309), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0198079 - link to the publication
  8. Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part A.
    Authors:
    Suchorska WM, Augustyniak E, Richter M, Trzeciak T.
    Academic press:
    Mol Med Rep. (rok: 2017, tom: May;15(5), strony: 2387-2401.), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2017.6334. - link to the publication
  9. A feeder- and xeno-free human induced pluripotent stem cell line obtained from primary human dermal fibroblasts with epigenetic repression of reprogramming factors expression: GPCCi001-A.
    Authors:
    Lach MS, Wroblewska JP, Augustyniak E, Kulcenty K, Suchorska WM.
    Academic press:
    Stem Cell Research (rok: 2017, tom: Apr;20, strony: 34-37), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2017.02.004 - link to the publication
  10. Actual strategies in human induced pluripotent stem cells (hiPSCs) differentiation – perspectives and challenges
    Authors:
    Ewelina Augustyniak, Katarzyna Kulcenty, Michał Lach, Igor Piotrowski , Wiktoria Maria Suchorska
    Academic press:
    Diagn Lab. Journal of Laboratory Diagnostics (rok: 2016, tom: 52 (2), strony: 123-136), Wydawca: Fundacja Rozwoju Diagnostyki Laboratoryjnej
    Status:
    Published
    DOI:
    brak - link to the publication
  11. Chondrogenic Differentiation of Pluripotent Stem Cells under Controllable Serum-Free Conditions.
    Authors:
    Lach MS, Wroblewska J, Kulcenty K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Int J Mol Sci. (rok: 2019, tom: Jun 2;20(11), strony: pii: E2711), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20112711 - link to the publication
  12. Modified methods for efficiently differentiating human embryonic stem cells into chondrocyte-like cells
    Authors:
    Suchorska WM, Augustyniak E, Filas V, Richter M, Łukjanow M, Kaczmarczyk J
    Academic press:
    Post MeD i Hig Dośw (rok: 2017, tom: Jun 19;71(0), strony: 500-509), Wydawca: Instytut Immunologii i Terapii Doświadczalnej PAN
    Status:
    Published
    DOI:
    brak - link to the publication
  13. The Role of MicroRNAs in Early Chondrogenesis of Human Induced Pluripotent Stem Cells (hiPSCs).
    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Richter M, Trzeciak T, Suchorska WM.
    Academic press:
    Int J Mol Sci (rok: 2019, tom: sep 5;20(18), strony: pii: E4371), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms20184371 - link to the publication
  14. The role of growth factors in stem cell-directed chondrogenesis: a real hope for damaged cartilage regeneration
    Authors:
    Ewelina Augustyniak & Tomasz Trzeciak & Magdalena Richter & Jacek Kaczmarczyk & Wiktoria Suchorska
    Academic press:
    International Orthopaedics (SICOT) (rok: 2015, tom: 39(5), strony: 995-1003), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s00264-014-2619-0 - link to the publication
  15. Bioimaging: An Useful Tool to Monitor Differentiation of Human Embryonic Stem Cells into Chondrocytes.
    Authors:
    Suchorska WM, Lach MS, Richter M, Kaczmarczyk J, Trzeciak T
    Academic press:
    Ann Biomed Eng. (rok: 2016, tom: 44(5), strony: 1845-59), Wydawca: Springer Link
    Status:
    Published
    DOI:
    10.1007/s10439-015-1443-z - link to the publication
  16. Chondrocytes differentiated from human induced pluripotent stem cells: Response to ionizing radiation.
    Authors:
    Stelcer E, Kulcenty K, Suchorska WM.
    Academic press:
    PLoS One. 2018 Oct 23;13(10):e0205691 (rok: 2018, tom: 13(10), strony: 45306), Wydawca: PLOS
    Status:
    Published
    DOI:
    10.1371/journal.pone.0205691 - link to the publication
  17. Effect of cellular mass on chondrogenic differentiation during embryoid body formation.
    Authors:
    Lach MS, Kulcenty K, Jankowska K, Trzeciak T, Richter M, Suchorska WM.
    Academic press:
    Mol Med Rep. (rok: 2018, tom: Sep;18(3), strony: 2705-2714), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/mmr.2018.9272 - link to the publication
  18. Expression of Pluripotency Genes in Chondrocyte-Like Cells Differentiated from Human Induced Pluripotent Stem Cells.
    Authors:
    Stelcer E, Kulcenty K, Rucinski M, Jopek K, Trzeciak T, Richter M, Wroblewska JP, Suchorska WM.
    Academic press:
    Int J Mol Sci. (rok: 2018, tom: Feb 12;19(2)., strony: piiE550), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19020550. - link to the publication
  19. Gene expression profile in human induced pluripotent stem cells: Chondrogenic differentiation in vitro, part B.
    Authors:
    Augustyniak E, Suchorska WM, Trzeciak T, Richter M.
    Academic press:
    Mol Med Rep. (rok: 2017, tom: May;15(5), strony: 2402-2414.), Wydawca: Spandidos Publication
    Status:
    Published
    DOI:
    10.3892/mmr.2017.6335 - link to the publication
  20. Genetic stability of pluripotent stem cells during anti-cancer therapies
    Authors:
    Suchorska WM, Augustyniak E, Łukjanow M.
    Academic press:
    Exp Ther Med. (rok: 2016, tom: 11(3), strony: 695–702), Wydawca: Spandidos
    Status:
    Published
    DOI:
    10.3892/etm.2016.2993 - link to the publication
  21. The role of exosomes in tumor progression and metastasis
    Authors:
    WM Suchorska, M Lach
    Academic press:
    Oncology Reports (rok: 2016, tom: 35(3), strony: 1237-1244), Wydawca: Spandidos
    Status:
    Published
    DOI:
    10.3892/or.2015.4507 - link to the publication

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