Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Influence of dicarboxylate on in vitro cytotoxic properties of platinum(II) coordination compounds with substituted triazolopyrimidines

2012/07/N/ST5/00221

Keywords:

platinum(II) complexes triazolopyrimidines dicarboxylates 15N NMR X-ray in vitro cytotoxicity glutathione affinity lipophilicity

Descriptors:

  • ST5_14: Other related subjects
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Mikołaja Kopernika, Wydział Chemii

woj. kujawsko-pomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

Kamil Hoffmann 

Number of co-investigators in the project: 2

Call: PRELUDIUM 4 - announced on 2012-09-15

Amount awarded: 124 840 PLN

Project start date (Y-m-d): 2013-07-16

Project end date (Y-m-d): 2016-01-15

Project duration:: 30 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Łaźnia ultradźwiękowa firmy POLSONIC (10 000 PLN)
  2. Specjalistyczne oprogramowanie DIAMOND firmy Crystal Impact.
  3. Mieszadło magnetyczne z grzaniem RH KT/C + kontroler temperatury ETC 1 (5 000 PLN)
  4. Wytrząsarka Multi Reax firmy Heidolph.
  5. Suszarka laboratoryjna z wymuszonym obiegiem powietrza (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (4)
  1. Cytotoxic malonate platinum(II) complexes with 1,2,4-triazolo[1,5-a]pyrimidine derivatives: Structural characterization and mechanism of the suppression of tumor cell growth
    Authors:
    I. Łakomska, K. Hoffmann, A. Wojtczak, J. Sitkowski, E. Maj, J. Wietrzyk
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2014, tom: 141, strony: 188-197), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2014.08.005 - link to the publication
  2. Rational design of dicarboxylato platinum(II) complexes with purine-mimetic ligands as novel anticancer agents
    Authors:
    K. Hoffmann, J. Wiśniewska, A. Wojtczak, J. Sitkowski, A. Denslow, J. Wietrzyk, M. Jakubowski, I. Łakomska
    Academic press:
    Journal of Inorganic Biochemistry (rok: 2017, tom: 172, strony: 34-45), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jinorgbio.2017.04.003 - link to the publication
  1. A SERIES OF NOVEL PLATINUM(II) COMPLEXES CONTAINING PURINE BASED ANALOGUES: IN VITRO AND IN VIVO INVESTIGATION OF THE INFLUENCE OF DICARBOXYLATES AS WELL AS CARRIER LIGANDS ON THE THERAPEUTIC PROPERTIES
    Authors:
    K. K. Hoffmann
    Conference:
    European School of Medicinal Chemistry (rok: 2015, ), Wydawca: European Federation for Medicinal Chemistry
    Data:
    konferencja 28.06-2.07
    Status:
    Published
  2. The influence of 5,7-disubstituted-1,2,4-triazolo[1,5-a]pyrimidines on lipophilicity and in vitro cytotoxicity of novel malonate platinum(II) complexes
    Authors:
    K. Hoffmann, J. Sitkowski, A. Wojtczak, J. Wietrzyk, I. Łakomska
    Conference:
    12th International Symposium on Bioinorganic Chemistry (rok: 2013, ), Wydawca: Sun Yat-sen University
    Data:
    konferencja 3-6 grudzień
    Status:
    Published
  3. How structure of the malonate-containing platinum(II)complexes with triazolopyrimidines may affect their ability to inhibit growth of tumour as well as normal cells
    Authors:
    K. Hoffmann, J. Sitkowski, E. Maj, A. Wojtczak, J. Wietrzyk, I. Łakomska
    Conference:
    41th International Conference on Coordination Chemistry (rok: 2014, ), Wydawca: Singapore National Institute of Chemistry
    Data:
    konferencja 21-25 lipiec
    Status:
    Published
    DOI:
    link to the publication
  4. Lipophilic platinum(II) complexes with dicarboxylates: in vitro antiproliferative activity as well as the mechanism of the suppression of tumour cells growth"
    Authors:
    K. Hoffmann, E. Maj, A. Wojtczak, J. Wietrzyk, I. Łakomska
    Conference:
    12th European Biological Inorganic Chemistry Conference (rok: 2014, ), Wydawca: Springer
    Data:
    konferencja 24-28 Sierpień
    Status:
    Published

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