Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Antimicrobial prodrugs based on calixarenes

2012/07/B/ST5/00890

Keywords:

antybiotics drug-membrane interaction Langmuir films calixarene molecular dynamics

Descriptors:

  • ST5_15:
  • ST5_16:

Panel:

ST5 - Materials: materials synthesis, structure-properties relations, advanced and functional materials with designed properties, (macro)molecular architecture, material engineering

Host institution :

Uniwersytet Jagielloński, Wydział Chemii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Beata Korchowiec 

Number of co-investigators in the project: 5

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 383 000 PLN

Project start date (Y-m-d): 2013-06-27

Project end date (Y-m-d): 2016-06-26

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Dysk zewnętrzny (2 szt.) (678 PLN)
  2. Tensjometr optyczny (np. model THETA T200 firmy Attension Biolin Scientific) (110 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  1. Molecular Organization of Nalidixate Conjugated Calixarenes in Bacterial Model Membranes Probed by Molecular Dynamics Simulation and Langmuir Monolayer Studies
    Authors:
    Beata Korchowiec, Jacek Korchowiec, Marcelina Gorczyca, Jean-Bernard Regnouf de Vains, and Ewa Rogalska
    Academic press:
    Journal of Physical Chemistry B (rok: 2015, tom: 119, strony: 2990-3000), Wydawca: American Chemical Society
    Status:
    Published
    DOI:
    10.1021/jp507151 - link to the publication
  2. Two antibacterial nalidixate calixarene derivatives in cholesterol monolayers: Molecular dynamics and physicochemical effects
    Authors:
    B. Korchowiec, J. Korchowiec, M. Orlof-Naturalna, J.-B. Regnouf de Vains, E. Rogalska
    Academic press:
    Colloids and Surfaces B: Biointerfaces (rok: 2016, tom: 145, strony: 777-784), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.colsurfb.2016.05.082 - link to the publication
  3. Nanoscale investigation of the interaction of colistin with model phospholipid membranes by Langmuir technique and combined infrared and force spectroscopies
    Authors:
    O. Freudenthal, F. Quilès, G. Francius, K. Wojszko, M. Gorczyca, B. Korchowiec, E. Rogalska
    Academic press:
    BBA Biomembranes (rok: 2016, tom: 1858, strony: 2592-2602), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbamem.2016.07.015 - link to the publication
  4. The selective interactions of cationic tetra-p-guanidinoethylcalix[4]arene with lipid membranes: theoretical and experimental model studies
    Authors:
    Beata Korchowiec, Marcelina Gorczyca, Ewa Rogalska, Jean-Bernard Regnouf-de-Vains, Maxime Mourer, and Jacek Korchowiec
    Academic press:
    Soft Matter (rok: 2016, tom: 12, strony: 181-190), Wydawca: Royal Society of Chemistry
    Status:
    Published
    DOI:
    10.1039/c5sm01891a - link to the publication

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