Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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In vitro assessment of selected protumorigenic effects favoring breast cancer development after exposure to silver nanoparticles in combination with common cosmetic constituents: aluminium salts, parabens, and phthalates

2012/07/B/NZ7/04197

Keywords:

silver nanoparticles aluminium parabens phthalates breast cancer cosmetics

Descriptors:

  • NZ3_1: Cell biology
  • NZ1_1: Molecular biology
  • NZ6_8: Other related subjects

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Pracy im. prof. dr. med. Jerzego Nofera

woj. łódzkie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maciej Stępnik 

Number of co-investigators in the project: 10

Call: OPUS 4 - announced on 2012-09-15

Amount awarded: 598 780 PLN

Project start date (Y-m-d): 2013-08-13

Project end date (Y-m-d): 2017-05-12

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System do oceny przenikalności substancji przez skórę (komory dyfuzyjne Franza) (50 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  1. Genotoxic effects in transformed and non-transformed human breast cell lines after exposure to silver nanoparticles in combination with aluminium chloride, butylparaben or di-n-butylphthalate
    Authors:
    Roszak J., Domeradzka-Gajda K, Smok-Pieniążek A, Kozajda A, Spryszyńska S, Grobelny J, Tomaszewska E, Ranoszek-Soliwoda K, Cieślak M, Puchowicz D, Stępnik M
    Academic press:
    Toxicology in vitro (rok: 2017, tom: 45, strony: 181-193), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.tiv.2017.09.003 - link to the publication
  2. A study on the in vitro percutaneous absorption of silver nanoparticles in combination with aluminium chloride, methyl paraben or di-n-butyl phthalate.
    Authors:
    Domeradzka-Gajda K, Nocuń M, Roszak J, Janasik B, Quarles CD Jr, Wąsowicz W, Grobelny J, Tomaszewska E, Celichowski G, Ranoszek-Soliwoda K, Cieślak M, Puchowicz D, Gonzalez JJ, Russo RE, Stępnik M.
    Academic press:
    Toxicology Letters (rok: 2017, tom: 272, strony: 38–48), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.toxlet.2017.03.006 - link to the publication
  3. Inhibitory effect of silver nanoparticles on proliferation of estrogen-dependent MCF-7/BUS human breast cancer cells induced by butyl paraben or di-n-butyl phthalate
    Authors:
    Joanna Roszaka, Anna Smok-Pieniążek, Katarzyna Domeradzka-Gajda, Jarosław Grobelny, Emilia Tomaszewska, Katarzyna Ranoszek-Soliwoda, Grzegorz Celichowski, Maciej Stępnik
    Academic press:
    Toxicology and Applied Pharmacology (rok: 2017, tom: 337, strony: 45647), Wydawca: Elsevier
    Status:
    Published
  1. EFFECT OF SILVER NANOPARTICLES AND SELECTED COSMETIC INGREDIENTS ON ESTROGEN-DEPENDENT PROLIFERATION OF HUMAN CANCER BREAST CELL LINE
    Authors:
    J. Roszak, S. Spryszyńska, A. Smok-Pieniążek, M. Nocuń, W. Wąsowicz, J. Grobelny, E. Tomaszewska, G. Celichowski, M. Cieślak, D. Puchowicz and M. Stępnik
    Conference:
    7th POLISH CONFERENCE ON NANOTECHNOLOGY (rok: 2015, ), Wydawca: Centrum NanoBiomedyczne, Uniwersytet im. Adama Mickiewicza w Poznaniu
    Data:
    konferencja 24-27, czerwca
    Status:
    Published
  2. Polaryzation of phorbol myristate acetate-induced THP-1 macrophages following exposure to silver nanoparticles alone or in combination with aluminum chloride, butylparaben or dibutylphthalate
    Authors:
    J. Roszak, K. Domeradzka-Gajda, A. Smok-Pieniążek, J. Grobelny, E. Tomaszewska, G. Celichowski, M. Cieślak, D. Puchowicz, M. Stępnik
    Conference:
    NanoSafe2016 (rok: 2016, ), Wydawca: Minatec, Grenoble
    Data:
    konferencja 7-10 listopada 2016
    Status:
    Published
  3. Mutagenicity testing in non-transformed and transformed human breast cell lines after exposure to silver nanoparticles in combination with aluminum chloride, butylparaben, or dibutylphthalate
    Authors:
    Stępnik M, Domeradzka-Gajda K, Roszak J, Kozajda A, Smok-Pieniążek A, Grobelny J, Tomaszewska E, Celichowski G, Cieślak M, Puchowicz D
    Conference:
    ICONAN2016 (rok: 2016, ), Wydawca: University Pierre and Marie Curie, Paris
    Data:
    konferencja 28-30 września 2016
    Status:
    Published
  4. Combined effect of silver nanoparticles and other cosmetic additives on viability of human breast cell lines
    Authors:
    J. Roszak, S. Spryszynska, A. Smok-Pieniążek, M. Nocuń, K. Domeradzka, W. Wasowicz, J. Grobelny, E. Tomaszewska, G. Celichowski, M. Cieślak, D. Puchowicz, M. Stępnik
    Conference:
    EUROTOX 2015 Porto-Portugal (rok: 2015, ), Wydawca: Toxicology Letters, Abstracts / Toxicology Letters 238S (2015) S56–S383
    Data:
    konferencja 13-16 września
    Status:
    Published
  5. Effect of selected cosmetic ingredients on the in vitro percutaneous absorption of silver nanoparticles
    Authors:
    Stępnik M, Nocuń M, Domeradzka K, Roszak J, Janasik B, Wąsowicz W, Grobelny J, Tomaszewska E, Soliwoda K, Cieślak M, Puchowicz D
    Conference:
    EUROTOX 2015 Porto-Portugal (rok: 2015, ), Wydawca: Toxicology Letters, Abstracts / Toxicology Letters 238S (2015) S56–S383
    Data:
    konferencja 13-16 września
    Status:
    Published