Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Coronavirus and the cell: dyplomatic bag

2012/07/E/NZ6/01712

Keywords:

coronavirus endocytosis infection egzocytosis apoptosis

Descriptors:

  • NZ6_5: Virology
  • NZ3_1: Cell biology
  • NZ3_2: Cell physiology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Krzysztof Pyrć 

Number of co-investigators in the project: 5

Call: SONATA BIS 2 - announced on 2012-09-15

Amount awarded: 1 470 434 PLN

Project start date (Y-m-d): 2013-07-23

Project end date (Y-m-d): 2019-05-22

Project duration:: 70 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Waga laboratoryjna (1 688 PLN)
  2. Zestaw pipet (4 szt.) (6 480 PLN)
  3. pH-metr (3 567 PLN)
  4. Komora laminarna BSL3 (94 000 PLN)
  5. Mikroskop odwrócony z opcją fluorescencji (39 998 PLN)
  6. Zestaw do elektroforezy białek (15 000 PLN)
  7. Zestaw pipet wielokanałowych (2 szt.) (1 749 PLN)
  8. Kuchenka mikrofalowa (1 000 PLN)
  9. Mieszadło magnetyczne (1 328 PLN)
  10. Wytrząsarka kołyskowa (2 szt.) (10 000 PLN)
  11. Zestaw do elektroforezy DNA (15 000 PLN)

Information in the final report

  • Publication in academic press/journals (15)
  1. Novel Polyanions Inhibiting Replication of Influenza Viruses
    Authors:
    Ciejka J, Milewska A, Wytrwal M, Wojarski J, Golda A, Ochman M, Nowakowska M, Szczubialka K, Pyrc K.
    Academic press:
    Antimicrobial agents and chemotherapy (rok: 2015, tom: 60, strony: 1955-1966), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/AAC.02183-15 - link to the publication
  2. Structural characterization of HCoV-NL63 N-protein.
    Authors:
    Bozena Szelazek, Wojciech Kabala, Krzysztof Kus, Michal Zdzalik, Aleksandra Twarda-Clapa, Przemyslaw Golik, Michal Burmistrz, Dominik Florek, Benedykt Wladyka, Krzysztof Pyrc, Grzegorz Dubin
    Academic press:
    Journal of Virology (rok: 2017, tom: 91, strony: e02503-16), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JVI.02503-16 - link to the publication
  3. Biopolymeric nano/microspheres for selective and reversible adsorption of coronaviruses
    Authors:
    Justyna Ciejka, Karol Wolski, Maria Nowakowska, Krzysztof Pyrc, Krzysztof Szczubialka
    Academic press:
    Materials Science & Engineering C (rok: 2017, tom: 76, strony: 735–742), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.msec.2017.03.047 - link to the publication
  4. Canine Respiratory Coronavirus, Bovine Coronavirus, and Human Coronavirus OC43: Receptors and Attachment Factors.
    Authors:
    Szczepanski A, Owczarek K, Bzowska M, Gula K, Drebot I, Ochman M, Maksym B, Rajfur Z, Mitchell JA, Pyrc K.
    Academic press:
    Viruses (rok: 2019, tom: 11, strony: E328), Wydawca: Basel, Switzerland : MDPI
    Status:
    Published
    DOI:
    10.3390/v11040328 - link to the publication
  5. Entry of Human Coronavirus NL63 into the Cell.
    Authors:
    A Milewska, P Nowak, K Owczarek, A Szczepanski, M Zarebski, A Hoang-Bujnowicz, K Berniak, J Wojarski, S Zeglen, Z Baster, Z Rajfur, Pyrc K
    Academic press:
    Journal of Virology (rok: 2018, tom: 92, strony: e01933-17.), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JVI.01933-17 - link to the publication
  6. HTCC: Broad Range Inhibitor of Coronavirus Entry
    Authors:
    Aleksandra Milewska, Kamil Kaminski, Justyna Ciejka, Katarzyna Kosowicz, Slawomir Zeglen, Jacek Wojarski, Maria Nowakowska, Krzysztof Szczubiałka, Krzysztof Pyrc
    Academic press:
    PLoS One (rok: 2016, tom: 11, strony: e0156552), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal. - link to the publication
  7. Membrane Protein of Human Coronavirus NL63 Is Responsible for Interaction with the Adhesion Receptor
    Authors:
    Antonina Naskalska, Agnieszka Dabrowska, Artur Szczepanski, Aleksandra Milewska, Krzysztof Jasik, Krzysztof Pyrc
    Academic press:
    Journal of Virology (rok: 2019, tom: 93, strony: e00355-19), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JVI.00355-19. - link to the publication
  8. Synthetic sulfonated derivatives of poly(allylamine hydrochloride) as inhibitors of human metapneumovirus.
    Authors:
    Ciejka J, Botwina P, Nowakowska M, Szczubiałka K, Pyrc K.
    Academic press:
    PLoS One (rok: 2019, tom: 14, strony: e0214646), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0214646 - link to the publication
  9. The nucleocapsid protein of human coronavirus NL63.
    Authors:
    Zuwała K, Golda A, Kabala W, Burmistrz M, Zdzalik M, Nowak P, Kedracka-Krok S, Zarebski M, Dobrucki J, Florek D, Zeglen S, Wojarski J, Potempa J, Dubin G, Pyrc K.
    Academic press:
    PloS One (rok: 2015, tom: 10, strony: e0117833), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0117833. - link to the publication
  10. Canine respiratory coronavirus employs caveolin-1-mediated pathway for internalization to HRT-18G cells.
    Authors:
    Szczepanski A, Owczarek K, Milewska A, Baster Z, Rajfur Z, Mitchell JA, Pyrc K.
    Academic press:
    Veterinary Research (rok: 2018, tom: 49, strony: 55), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/s13567-018-0551-9 - link to the publication
  11. Human Coronavirus HKU1 Spike Protein Uses O-Acetylated Sialic Acid as an Attachment Receptor Determinant and Employs Hemagglutinin-Esterase Protein as a Receptor-Destroying Enzyme.
    Authors:
    Huang X, Dong W, Milewska A, Golda A, Qi Y, Zhu QK, Marasco WA, Baric RS, Sims AC, Pyrc K, Li W, Sui J.
    Academic press:
    Journal of virology (rok: 2015, tom: 89, strony: 7202-7213), Wydawca: American Society for Microbiology.
    Status:
    Published
    DOI:
    10.1128/JVI.00854-15 - link to the publication
  12. Human coronavirus NL63 utilizes heparan sulfate proteoglycans for attachment to target cells.
    Authors:
    Milewska Aleksandra, Zarebski Mirosław, Nowak Paulina, Stozek Karol, Potempa Jan, Pyrc Krzysztof
    Academic press:
    Journal of Virology (rok: 2014, tom: 88, strony: 13221-13230), Wydawca: American Society for Microbiology
    Status:
    Published
    DOI:
    10.1128/JVI.02078-14 - link to the publication
  13. Novel coronavirus-like particles targeting cells lining the respiratory tract.
    Authors:
    Naskalska A, Dabrowska A, Nowak P, Szczepanski A, Jasik K, Milewska A, Ochman M, Zeglen S, Rajfur Z, Pyrc K.
    Academic press:
    PLoS One (rok: 2018, tom: 13, strony: e0203489), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0203489 - link to the publication
  14. Substrate profiling of Zika virus NS2B-NS3 protease
    Authors:
    Natalia Gruba, Jose Ignacio Rodriguez Martinez, Renata Grzywa, Magdalena Wysocka, Marcin Skorenski, Michał Burmistrz, Maria Lecka, Adam Lesner, Marcin Sienczyk, Krzysztof Pyrc
    Academic press:
    Febs Letters (rok: 2016, tom: 590, strony: 3459–3468), Wydawca: Federation of European Biochemical Societies
    Status:
    Published
    DOI:
    10.1002/1873-3468.12443 - link to the publication
  15. Early events during human coronavirus OC43 entry to the cell.
    Authors:
    Owczarek K, Szczepanski A, Milewska A, Baster Z, Rajfur Z, Sarna M, Pyrc K.
    Academic press:
    Scientific Reports (rok: 2018, tom: 8, strony: 7124), Wydawca: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/s41598-018-25640-0 - link to the publication

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