Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Heme oxygenase-1 and progress of melanoma: role in cancer initiating cells

2012/06/M/NZ1/00008

Keywords:

heme oxygenase melanoma differentiation vasculogenic mimicry angiogenesis oxidative stress

Descriptors:

  • NZ1_1: Molecular biology

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Alicja Józkowicz 

Number of co-investigators in the project: 10

Call: HARMONIA 3 - announced on 2012-06-15

Amount awarded: 1 045 200 PLN

Project start date (Y-m-d): 2013-04-22

Project end date (Y-m-d): 2016-04-21

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (13)
  1. Heme oxygenase-1 controls an HDAC4 – miR206 pathway of oxidative stress in rhabdomyosarcoma
    Authors:
    Ciesla M, Marona P, Kozakowska M, Jez M, Seczynska M, Loboda A, Bukowska-Strakova K, Szade A, Walawender M, Kusior M, Stępniewski J, Szade K, Krist B, Yagensky O, Urbanik A, Kazanowska B, Dulak J, Jozkowicz A.
    Academic press:
    Canc Res (rok: 2016, tom: 76, strony: 45303), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Novel Faces of heme oxygenase: mechanisms and therapeutic potentials
    Authors:
    Jozef Dulak, Alicja Jozkowicz
    Academic press:
    Antioxidants & Redox Signaling (rok: 2014, tom: 20, strony: 1673-1676), Wydawca: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/ars.2013.5761 - link to the publication
  3. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism.
    Authors:
    Loboda A, Damulewicz M, Pyza E, Jozkowicz A, Dulak J.
    Academic press:
    Cell Mol Life Sci (rok: 2016, tom: 73, strony: 3221-3247), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-016-2223-0 - link to the publication
  4. Role of heme oxygenase-1 in postnatal differentiation of stem cells: a possible cross-talk with microRNAs
    Authors:
    Magdalena Kozakowska, Krzysztof Szade, Jozef Dulak, Alicja Jozkowicz
    Academic press:
    Antioxidants & Redox Signaling (rok: 2014, tom: 20, strony: 1827-1850), Wydawca: Mary Ann Liebert
    Status:
    Published
    DOI:
    10.1089/ars.2013.5341 - link to the publication
  5. HO-1/CO system in tumor growth, angiogenesis and metabolism - targeting HO-1 as an anti-tumor therapy
    Authors:
    Loboda A, Jozkowicz A, Dulak J.
    Academic press:
    Vascul Pharmacol (rok: 2015, tom: 74, strony: 45618), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.vph.2015.09.004. - link to the publication
  6. Hypoxia-regulated overexpression of soluble VEGFR2 controls angiogenesis and inhibits tumor growth
    Authors:
    Guillaume Collet, Nathalie Lamerant-Fayel, Magdalena Tertil, Bouchra El Hafny-Rahbi, Jacek Stepniewski, Alan Guichard, Alexandra Faucault-Collet, Krzysztof Klimkiewicz, Stephane Petoud, Agata Matejuk, Catherine Grillon, Alicja Jozkowicz, Jozef Dulak, Claudine Kieda
    Academic press:
    Molecular Cancer Therapeutics (rok: 2013, tom: 13, strony: 45305), Wydawca: American Association for Cancer Research
    Status:
    Published
    DOI:
    10.1158/1535-7163.MCT-13-0637 - link to the publication
  7. Nrf2-heme oxygenase-1 axis in mucoepidermoid carcinoma of the lung: antitumoral effects associated with down-regulation of matrix metalloproteinases.
    Authors:
    Tertil M, Golda S, Skrzypek K, Florczyk U, Weglarczyk K, Kotlinowski J, Maleszewska M, Czauderna S, Pichon C, Kieda C, Jozkowicz A, Dulak J.
    Academic press:
    Free Radic Biol Med (rok: 2015, tom: 89, strony: 147-157), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.freeradbiomed.2015.08.004. - link to the publication
  8. A 3D model of tumor angiogenic microenvironment to monitor hypoxia effects on cell interactions and cancer stem cell selection
    Authors:
    Klimkiewicz K, Weglarczyk K, Collet G, Guichard A, Jozkowicz A, Dulak J, Sarna T, Grillon C, Kieda C
    Academic press:
    Cancer Lett (rok: 2017, tom: 396, strony: 45585), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2017.03.006 - link to the publication
  9. Endothelial precursor cell-based therapy to target the pathologic angiogenesis and compensate tumor hypoxia.
    Authors:
    Collet G, Szade K, Nowak W, Klimkiewicz K, El Hafny-Rahbi B, Szczepanek K1, Sugiyama D, Weglarczyk K, Foucault-Collet A, Guichard A, Mazan A, Nadim M, Fasani F, Lamerant-Fayel N, Grillon C, Petoud S, Beloeil JC, Jozkowicz A, Dulak J, Kieda C.
    Academic press:
    Cancer Lett (rok: 2016, tom: 370, strony: 345-357), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.canlet.2015.11.008. - link to the publication
  10. MicroRNAs and epigenetic mechanisms of rhabdomyosarcoma development.
    Authors:
    Maciej Ciesla, Jozef Dulak, Alicja Jozkowicz
    Academic press:
    International Journal of Biochemistry and Cell Biology (rok: 2014, tom: 53, strony: 482-492), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.biocel.2014.05.003 - link to the publication
  11. Myoblast-conditioned media improve regeneration and revascularization of ischemic muscles in diabetic mice
    Authors:
    Kozakowska M, Kotlinowski J, Grochot-Przeczek A, Ciesla M, Pilecki B, Derlacz R, Dulak J, Jozkowicz A.
    Academic press:
    Stem Cell Res Ther (rok: 2015, tom: 6, strony: 61-77), Wydawca: BMC
    Status:
    Published
    DOI:
    10.3390/jcm5030029 - link to the publication
  12. Cellular and molecular mechanisms of inflammation-induced angiogenesis.
    Authors:
    Agata Szade, Anna Grochot-Przeczek, Urszula Florczyk, Alicja Jozkowicz, Jozef Dulak
    Academic press:
    IUBMB Life (rok: 2015, tom: 67, strony: 145-159), Wydawca: Wiley
    Status:
    Published
    DOI:
    10.1002/iub.1358 - link to the publication
  13. Spheroid-plug model as a tool to study tumor development, angiogenesis, and heterogeneity in vivo.
    Authors:
    Szade K, Zukowska M, Szade A, Collet G, Kloska D, Kieda C, Jozkowicz A, Dulak J.
    Academic press:
    Tumor Biol (rok: 2016, tom: 37, strony: 2481-2496), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s13277-015-4065-z. - link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy