Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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"RNA toxicity in pathogenesis of polyglutamine diseases"

2012/06/A/NZ1/00094

Keywords:

RNA toxicity polyglutamine diseases trinucleotide repeats RNA foci HD SCA3

Descriptors:

  • NZ1_1: Molecular biology
  • NZ1_5: Genetic engineering
  • NZ1_7: Cell engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej PAN

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Maciej Figiel 

Number of co-investigators in the project: 10

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 2 996 500 PLN

Project start date (Y-m-d): 2013-03-22

Project end date (Y-m-d): 2019-03-21

Project duration:: 72 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Termocykler (2 szt) i aparat do hybrydyzacji "dot blot" z pompą.

Information in the final report

  • Publication in academic press/journals (21)
  • Book publications / chapters in book publications (1)
  1. Discriminating RNA variants with single-molecule allele-specific FISH
    Authors:
    Urbanek MO, Krzyzosiak WJ
    Academic press:
    Mutation Research. Reviews in Mutation Research (rok: 2017, tom: 773, strony: 230-241), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.mrrev.2016.09.003 - link to the publication
  2. Generation of human iPS cell line IBCHi002-A from spinocerebellar ataxia type 3/Machado-Joseph disease patient's fibroblasts
    Authors:
    Agata Ciolak, Wlodzimierz J Krzyzosiak, Emilia Kozlowska, Agnieszka Fiszer
    Academic press:
    Stem Cell Research (rok: 2020, tom: 45, strony: 101796), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.scr.2020.101796 - link to the publication
  3. 2D and 3D FISH of expanded repeat RNAs in human lymphoblasts
    Authors:
    Urbanek MO, Michalak M, Krzyzosiak WJ
    Academic press:
    Methods (rok: 2017, tom: 120, strony: 49-57), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymeth.2017.04.002 - link to the publication
  4. Modeling simple repeat expansion diseases with iPSC technology
    Authors:
    Jaworska E, Kozlowska E, Switonski PM, Krzyzosiak WJ
    Academic press:
    Cellular and Molecular Life Sciences (rok: 2016, tom: 73, strony: 4085-4100), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-016-2284-0 - link to the publication
  5. Nuclear speckles are detention centers for transcripts containing expanded CAG repeats
    Authors:
    Urbanek MO, Jazurek M, Switonski PM, Figura G, Krzyzosiak WJ
    Academic press:
    Biochimica et Biophysica Acta - Molecular Basis of Disease (rok: 2016, tom: 1862, strony: 1513-1520), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbadis.2016.05.015 - link to the publication
  6. RNA FISH for detecting expanded repeats in human diseases
    Authors:
    Urbanek MO, Krzyzosiak WJ
    Academic press:
    Methods (rok: 2015, tom: 2015, strony: S1046-2023), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.ymeth.2015.11.017 - link to the publication
  7. Sequence-non-specific effects generated by various types of RNA interference triggers
    Authors:
    Olejniczak M, Urbanek MO, Jaworska E, Witucki L, Szczesniak MW, Makalowska I, Krzyzosiak WJ.
    Academic press:
    Biochimica et Biophysica Acta (rok: 2015, tom: 1859(2), strony: 306–314), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2015.11.005 - link to the publication
  8. siRNA release from pri-miRNA scaffolds is controlled by the sequence and structure of RNA
    Authors:
    Galka-Marciniak P, Olejniczak M, Starega-Roslan J, Szczesniak MW, Makalowska I, Krzyzosiak WJ
    Academic press:
    Biochimica et Biophysica Acta - Gene Regulatory Mechanisms (rok: 2016, tom: 1859, strony: 639-649), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.bbagrm.2016.02.014 - link to the publication
  9. Identifying proteins that bind to specific RNAs - focus on simple repeat expansion diseases
    Authors:
    Jazurek M, Ciesiolka A, Starega-Roslan J, Bilinska K, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (rok: 2016, tom: 44, strony: 9050-9070), Wydawca: OXFORD ACADEMIC
    Status:
    Published
    DOI:
    10.1093/nar/gkw803 - link to the publication
  10. Current understanding of the role of microRNAs in spinocerebellar ataxias
    Authors:
    Edyta Koscianska and Wlodzimierz J Krzyzosiak
    Academic press:
    Cerebellum and Ataxias (rok: 2014, tom: 0,0465277777777778, strony: bd), Wydawca: BioMed Central
    Status:
    Published
    DOI:
    10.1186/2053-8871-1-7 - link to the publication
  11. In Vitro Expansion of CAG, CAA, and Mixed CAG/CAA Repeats
    Authors:
    Figura G, Koscianska E, Krzyzosiak WJ.
    Academic press:
    International Journal of Molecular Sciences (rok: 2015, tom: 16(8), strony: 18741-18751), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms160818741 - link to the publication
  12. RAN translation and frameshifting as translational challenges at simple repeats of human neurodegenerative disorders
    Authors:
    Wojciechowska M, Olejniczak M, Galka-Marciniak P, Jazurek M, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42(19), strony: 11849-64), Wydawca: Oxford Univ Press
    Status:
    Published
    DOI:
    10.1093/nar/gku794 - link to the publication
  13. Small RNA Detection by in Situ Hybridization Methods
    Authors:
    Urbanek MO, Nawrocka AU, Krzyzosiak WJ.
    Academic press:
    International Journal of Molecular Sciences (rok: 2015, tom: 16(6), strony: 13259-13286), Wydawca: MDPI AG
    Status:
    Published
    DOI:
    10.3390/ijms160613259 - link to the publication
  14. miRNAmotif—A Tool for the Prediction of Pre-miRNA–Protein Interactions
    Authors:
    Urbanek-Trzeciak MO, Jaworska E, Krzyzosiak WJ
    Academic press:
    International Journal of Molecular Sciences (rok: 2018, tom: 19, strony: 4075), Wydawca: MDPI
    Status:
    Published
    DOI:
    10.3390/ijms19124075 - link to the publication
  15. Cooperation meets competition in microRNA-mediated DMPK transcript regulation
    Authors:
    Koscianska E, Witkos TM, Kozlowska E, Wojciechowska M, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 9500-9518), Wydawca: OXFORD UNIV PRESS
    Status:
    Published
    DOI:
    10.1093/nar/gkv849 - link to the publication
  16. Nuclear speckles: molecular organization, biological function and role in disease
    Authors:
    Galganski L, Urbanek MO, Krzyzosiak WJ
    Academic press:
    Nucleic Acids Research (rok: 2017, tom: 45, strony: 10350-10368), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkx759 - link to the publication
  17. RAN Translation of the Expanded CAG Repeats in the SCA3 Disease Context
    Authors:
    Magdalena Jazurek-Ciesiolka, Adam Ciesiolka, Alicja A.Komur, Martyna O.Urbanek-Trzeciak, Wlodzimierz J.Krzyzosiak, AgnieszkaFiszer
    Academic press:
    Journal of Molecular Biology (rok: 2020, tom: 432, strony: 166699), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.033 - link to the publication
  18. RNA imaging in living cells - methods and applications
    Authors:
    Urbanek MO, Galka-Marciniak P, Olejniczak M, Krzyzosiak WJ
    Academic press:
    RNA Biology (rok: 2014, tom: 3;11(8), strony: 1083-95), Wydawca: Landes Bioscience
    Status:
    Published
    DOI:
    10.4161/rna.35506 - link to the publication
  19. Reduction of Huntington's Disease RNA Foci by CAG Repeat-Targeting Reagents
    Authors:
    Urbanek MO, Fiszer A, Krzyzosiak WJ
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2017, tom: 11, strony: 82), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00082 - link to the publication
  20. Structural Characteristics of Simple RNA Repeats Associated with Disease and their Deleterious Protein Interactions
    Authors:
    Ciesiolka A, Jazurek M, Drazkowska K, Krzyzosiak WJ
    Academic press:
    Frontiers in Cellular Neuroscience (rok: 2017, tom: 11, strony: 97), Wydawca: Frontiers Media SA
    Status:
    Published
    DOI:
    10.3389/fncel.2017.00097 - link to the publication
  21. The role of the immune system in triplet repeat expansion diseases.
    Authors:
    Olejniczak M, Urbanek MO, Krzyzosiak WJ.
    Academic press:
    Mediators of Inflammation (rok: 2015, tom: -, strony: 873860), Wydawca: HINDAWI PUBLISHING CORPORATION
    Status:
    Published
    DOI:
    10.1155/2015/873860 - link to the publication
  1. MicroRNA deregulation in trinucleotide repeat expansion disorders
    Authors:
    Koscianska E, Kozlowska E, Jaworska E, Krzyzosiak WJ.
    Book:
    Applied RNAi: From Fundamental Research to Therapeutic Applications (rok: 2014, tom: bd, strony: 227-246), Wydawca: Caister Academic Press
    Status:
    Published

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