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Neurotoxic oligomers of human cystatin C - identification and structural studies

2012/06/M/ST4/00036

Keywords

Descriptors

  • ST4_4: Struktura i architektura molekularna
  • ST4_13: Chemia fizyczna układów biologicznych
  • ST4_3: Metody spektroskopowe i spektrometryczne

Panel

ST4 – Chemistry: physical chemistry/chemical physics, theoretical chemistry, analytical chemistry, inorganic chemistry, organic chemistry, method development

Host institution

Uniwersytet im. Adama Mickiewicza w Poznaniu, Wydział Fizyki

Voivodeship: wielkopolskie

Other projects carried out by the institution »

Principal investigator (from the host institution)

prof. Maciej Leszek Kozak

Number of co-investigators in the project: 9

Call

HARMONIA 3 – announced on 2012-06-15

Amount awarded
630 500 PLN
Project start date
2013-04-09
Project end date
2017-04-08
Project duration
48 months (the same as in the proposal)
Project status
Project settled

Information in the final report

Publication in academic press/journals (7)

  1. Stabilization, Characterization and Selective Removal of Cystatin C Amyloid Oligomers

    Authors:
    Gustav Ranheimer Östner, Veronica Lindström, Per Hjort Christensen, Maciej Kozak, Magnus Abrahamson and Anders Grubb
    Academic press:
    The Journal of Biological Chemistry (year: 2013, volume: 288, pages: 16438-16450), Publisher: American Society of Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M113.469593 – link to the publication

  2. Effect of calcium ions on structure and stability of the C1q-like domain of otolin-1 from human and zebrafish

    Authors:
    Rafał Hołubowicz, Magdalena Wojtas, Michał Taube, Maciej Kozak, Andrzej Ożyhar, Piotr Dobryszycki
    Academic press:
    The FEBS Journal (year: 2017, volume: 284, pages: 4278–4297), Publisher: Federation of European Biochemical Societies
    Status:
    Published
    DOI:
    10.1111/febs.14308 – link to the publication

  3. The method of purifying bioengineered spider silk determines the secondary structure of soluble silk and silk sphere properties

    Authors:
    Katarzyna Jastrzebska, Edyta Felcyn, Maciej Kozak, Miroslaw Szybowicz, Tomasz Buchwald, Zuzanna Pietralik, Teofil Jesionowski, Andrzej Mackiewicz, Hanna Dams- Kozlowska
    Academic press:
    Scientific Reports (year: 2016, volume: 6, pages: 28106), Publisher: Nature Publishing Group
    Status:
    Published
    DOI:
    10.1038/srep28106 – link to the publication

  4. Overall conformation of covalently stabilized domain-swapped dimer of human cystatin C in solution

    Authors:
    Magdalena Murawska, Aneta Szymańska, Anders Grubb, Maciej Kozak
    Academic press:
    Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms (year: 2017, volume: 411, pages: 136-140), Publisher: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.nimb.2017.02.090 – link to the publication

  5. Cyclic trimer of human cystatin C, an amyloidogenic protein - molecular dynamics and experimental studies

    Authors:
    Magdalena Murawska, Martyna Maszota-Zieleniak, Zuzanna Pietralik, Michał Taube, Sylwia Rodziewicz-Motowidło, Aneta Szymańska, Kosma Szutkowski, Daniel Clemens, Anders Grubb, Maciej Kozak
    Academic press:
    Journal of Applied Physics (year: 2018, volume: 123, pages: 174701 (pages 1-10)), Publisher: American Institute of Physics
    Status:
    Published
    DOI:
    10.1063/1.5023807 – link to the publication

  6. Bioengineering the spider silk sequence to modify its affinity for drugs

    Authors:
    Kamil Kucharczyk, Marek Weiss, Katarzyna Jastrzebska, Magdalena Luczak, Arkadiusz Ptak, Maciej Kozak, Andrzej Mackiewicz, Hanna Dams-Kozlowska
    Academic press:
    International Journal of Nanomedicine (year: 2018, volume: 13, pages: 4247-4261), Publisher: Dovepress
    Status:
    Published
    DOI:
    10.2147/IJN.S168081 – link to the publication

  7. The domain swapping of human cystatin C induced by synchrotron radiation

    Authors:
    Michał Taube, Zuzanna Pietralik, Aneta Szymańnska, Kosma Szutkowski, Daniel Clemens, Anders Grubb and Maciej Kozak
    Status:
    Accepted for publication

Articles in post-conference publications (25)

  1. Oligomerization process of HCC and its mutants - electrophoretic and fluorescent studies

    Authors:
    Zuzanna Pietralik, Aneta Szymanska, Janet R. Kumita, Christopher M. Dobson and Maciej Kozak
    Conference:
    Cystatins 2016 (year: 2016, pages: 13-14), Publisher: Lund University
    Date:
    conference 2 - 4/06/2016
    Status:
    Published

  2. Self-association of HCC oligomers - AFM studies

    Authors:
    Zuzanna Pietralik, Janet R. Kumita, Christopher M. Dobson, Anders Grubb and Maciej Kozak
    Conference:
    Cystatins 2016 (year: 2016, pages: 12), Publisher: Lund University
    Date:
    conference 2 - 4/06/2016
    Status:
    Published

  3. Conformational changes of peptides based on human Cystatin C steric zipper region in the presence of gemini surfactants

    Authors:
    Weronika Andrzejewska, Julia Ludwiczak, Emilia Iłowska, Aneta Szymańska and Maciej Kozak
    Conference:
    13th International School and Symposium on Synchrotron Radiation in Natural Science (year: 2016, pages: 93), Publisher: PTPS - Synchrotron Radiation in Natural Science Vol. 15, No. 1 – 2 (2016)
    Date:
    conference 13 - 18/06/2016
    Status:
    Published

  4. Circular dichroism studies of possible changes in protein secondary structure induced by uranyl formate

    Authors:
    Julia Ludwiczak, Maciej Gielnik, Maciej Kozak
    Conference:
    50th Zakopane School of Physics (year: 2015, pages: Book of Abstracts, p 107), Publisher: IFJ PAN
    Date:
    conference 18-23/05/2015
    Status:
    Published

  5. Spectroscopic characterization of human cystatin C and its mutants

    Authors:
    Zuzanna Pieralik, Aneta Szymańska, Maciej Kozak
    Conference:
    KSUPS 2015 (year: 2015, pages: 54), Publisher: PTPS - Synchrotron Radiation in Natural Science Vol. 14, No. 1 – 2 (2015)
    Date:
    conference 1-4/09/2015
    Status:
    Published

  6. SAXS studies of selected flexible proteins or proteins of modular structure

    Authors:
    Maciej Kozak, Zuzanna Pietralik, Michał Taube
    Conference:
    KSUPS 2015 (year: 2015, pages: 28-29), Publisher: PTPS - Synchrotron Radiation in Natural Science Vol. 14, No. 1 – 2 (2015)
    Date:
    conference 1-4/09/2015
    Status:
    Published

  7. The order-disorder processes in solution SAXS studies of the protein folding

    Authors:
    Maciej Kozak, Michał Taube, Zuzanna Pietralik, Fabian Giska, Magdalena Krzymowska, Jacek Hennig, Andrzej Ożyhar, Aneta Szymańska
    Conference:
    Second Polish-Korean Conference on Protein Folding Theoretical and Experimental Approaches (year: 2016, pages: 25), Publisher: Uniwersytet Gdański
    Date:
    conference 28/05 – 01/06/2016
    Status:
    Published

  8. Structural Studies of the Oligomerization Process of Human Cystatin C Variants

    Authors:
    Zuzanna Pietralik, Magdalena Murawska, Aneta Szymanska, Janet R. Kumita, Christopher M. Dobson, Maciej Kozak
    Conference:
    60th Annual Meeting Biophysical Society (year: 2016, pages: Biophys J 110, 3, S1, p26a,), Publisher: Biophysical Society. Published by Elsevier Inc.
    Date:
    conference 27/02-2/03/2016
    Status:
    Published
    DOI:
    link to the publication

  9. Radiation damages in BioSAXS - comparison of changes induced by synchrotron radiation and lab source

    Authors:
    Maciej Kozak, Michał Taube, Zuzanna Pietralik, Maciej Gielnik, Aneta Szymańska, Igor Zhukov
    Conference:
    10th International Conference on X-Ray Investigations of Polymer Structure (year: 2016, pages: 37), Publisher: ATH
    Date:
    conference 6 - 9/12/2016
    Status:
    Published

  10. Otrzymywanie oraz charakterystyka oligomerów ludzkiej cystatyny C oraz jej punktowych mutantów

    Authors:
    Zuzanna Pietralik, Aneta Szymańska, Janet R. Kumita, Christopher M. Dobson
    Conference:
    IX Seminarium STM/AFM 2016 (year: 2016, pages: 91), Publisher: Instytut Fizyki, Uniwersytet Jagielloński
    Date:
    conference 30/11 - 4/12/2016
    Status:
    Published

  11. Proces oligomeryzacji i jego znaczenie w chorobach neurodegeneracyjnych na przykładzie ludzkiej cystatyny C

    Authors:
    Zuzanna Pietralik, Aneta Szymańska, Janet R. Kumita, Christopher M. Dobson, Maciej Kozak
    Conference:
    Konferencja Polskiego Towarzystwa Fizyki Medycznej (year: 2017, pages: 44-45), Publisher: PTFM
    Date:
    conference 1-3 czerwca
    Status:
    Published

  12. Characterization of human cystain C variants - structural and spectroscopic studies

    Authors:
    Zuzanna Pietralik, Michał Taube, Aneta Szymańska, Janet R. Kumita, Christopher M. Dobson, Maciej Kozak
    Conference:
    10th International Conference on X-Ray Investigations of Polymer Structure (year: 2016, pages: 72-73), Publisher: ATH
    Date:
    conference 6 - 9/12/2016
    Status:
    Published

  13. BioSAXS – a tool for structural studies of complex or disordered biomacromolecules

    Authors:
    Maciej Kozak, Michał Taube, Zuzanna Pietralik, Maciej Gielnik, Julia Ludwiczak, Aneta Szymańska, Igor Zhukov
    Conference:
    Bio2016 – Expanding beyond the limit - 2nd Congress of Polish Biochemistry, Cell Biology, Biotechnology and Bioinformatics (year: 2016, pages: 100), Publisher: Polskie Towarzystwo Biochemiczne - Acta Biochimica Polonica, Supplement 2, 2016
    Date:
    conference 13 - 16/09/2016
    Status:
    Published

  14. Oligomerization and structural characterization of native human cystatin C and its single-point mutants

    Authors:
    Zuzanna Pietralik, Aneta Szymanska, Janet R. Kumita, Christopher M. Dobson, Maciej Kozak
    Conference:
    13th International School and Symposium on Synchrotron Radiation in Natural Science (year: 2016, pages: 105), Publisher: PTPS - Synchrotron Radiation in Natural Science Vol. 15, No. 1 – 2 (2016)
    Date:
    conference 13 - 18/06/2016
    Status:
    Published

  15. Oligomeric states of Human Cystatin C variants – atomic force microscopy and spectroscopic studies

    Authors:
    Zuzanna Pietralik, Żaneta Kołodziejska, Aneta Szymanska, Janet R. Kumita, Christopher M. Dobson, Maciej Kozak
    Conference:
    Alzheimer's disease and neurodegenerative disorders: what challenges for tomorrow (year: 2016, pages: 433), Publisher: Folia Neuropathologica 54/4
    Date:
    conference 42471
    Status:
    Published

  16. Methylamine vanadate can change overall secondary structure of proteins

    Authors:
    Maciej Gielnik, Julia Ludwiczak, Maciej Kozak
    Conference:
    50th Zakopane School of Physics (year: 2015, pages: Book of Abstracts, p 105), Publisher: IFJ PAN
    Date:
    conference 18-23/05/2015
    Status:
    Published

  17. Structure of HCC oligomers – SAXS and MD studies

    Authors:
    Magdalena Murawska, Anders Grubb, Martyna Maszota, Sylwia Rodziewicz-Motowidło, Maciej Kozak
    Conference:
    KSUPS2012 (year: 2013, pages: 45), Publisher: PTPS - Synchrotron Radiation in Natural Science Vol. 12, No. 1 – 2 (2013)
    Date:
    conference 9-11/09/2013
    Status:
    Published
    DOI:
    link to the publication

  18. Molecular dynamic of donut-like form of human cystatin C in solution

    Authors:
    Magdalena Murawska, Andres Grubb, Sylwia Rodziewicz-Motowidło, Marta Maszota, Maciej Kozak.
    Conference:
    XV Zjazd Polskiego Towarzystwa Biofizycznego, (year: 2013, pages: P-083 Book of Abstracts p. 72.), Publisher: PTBiofiz
    Date:
    conference Nałęczów 26-28 czerwca 2013,
    Status:
    Published

  19. Small angle X-ray scattering (SAXS) studies of human cystatin C in solution

    Authors:
    Magdalena Murawska, Anders Grubb, Maciej Kozak.
    Conference:
    XV Zjazd Polskiego Towarzystwa Biofizycznego, (year: 2013, pages: P-085 Book of Abstracts p. 73.), Publisher: PTBiofiz
    Date:
    conference Nałęczów 26-28 czerwca 2013,
    Status:
    Published

  20. Spectroscopic and SAXS Studies of Human Cystatin C Mutants - Early Stages of Amyloid Formation Process

    Authors:
    Maciej Kozak, Zuzanna Pietralik, Aneta Szymanska, Michał Taube
    Conference:
    59BPS Meeting (year: 2015, pages: Biophysical Journal, Vol 108(2) Suppl. 1, p516a), Publisher: Biophysical Society
    Date:
    conference 7-11/02/2015
    Status:
    Published
    DOI:
    link to the publication

  21. Molecular dynamics simulation studies of human cystatin C oligomerization

    Authors:
    Magdalena Murawska, Sylwia Rodziewicz Motowidło, Maciej Kozak
    Conference:
    BIO Congress Warsaw, Poland September 9th–12th 2014 (year: 2014, pages: 80), Publisher: Polish Biochemical Society and of the Committee of Biochemistry and Biophysics Polish Academy of Sciences
    Date:
    conference 9-12/09/2014
    Status:
    Published
    DOI:
    link to the publication

  22. Interactions of synchrotron radiation with biological samples - radiation induced domain swapping

    Authors:
    Maciej Kozak, Michał Taube, Zuzanna Pietralik, Anders Grubb, Aneta Szymańska
    Conference:
    50th Zakopane School of Physics (year: 2015, pages: Book of Abstracts, p 17), Publisher: IFJ PAN
    Date:
    conference 18-23/05/2015
    Status:
    Published

  23. Time-resolved SAXS studies of human cystatin C – first observation of radiation induced domain swapping

    Authors:
    Maciej Kozak, Michał Taube, Magdalena Murawska, Aneta Szymanska, Anders Grubb
    Conference:
    International Meeting CYSTATINS 2014 (year: 2014, pages: 10), Publisher: Fundacja Centrum Transferu Technologii Synergy
    Date:
    conference 12-14.06.2014
    Status:
    Published

  24. Human cystatin C oligomers and radiation induced domain swapping

    Authors:
    Maciej Kozak, Michał Taube, Aneta Szymańska, Anders Grubb
    Conference:
    Protein Folding Conference 2014 (year: 2014, pages: 64), Publisher: Zing conferences
    Date:
    conference 16-19/07/2014
    Status:
    Published

  25. Molecular dynamics simulation studies of HCC oligomeric forms

    Authors:
    Magdalena Murawska, Anders Grubb, Martyna Maszota, Sylwia Rodziewicz- Motowidło, Maciej Kozak
    Conference:
    International Meeting CYSTATINS 2014, (year: 2014, pages: 9), Publisher: Fundacja Centrum Transferu Technologii Synergy
    Date:
    conference 12-14.06.2014
    Status:
    Published

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