Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Role of microRNAs and inflammation in injury and regeneration of skeletal muscles in Duchenne muscular dystrophy

2012/06/A/NZ1/00004

Keywords:

microRNA miR-378 miR-146a myoblasts satellite cells heme oxygenase-1 Nrf2 induced pluripotent stem cells

Descriptors:

  • NZ1_1:
  • NZ3_1:
  • NZ3_8:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Jagielloński, Wydział Biochemii, Biofizyki i Biotechnologii

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Józef Dulak 

Number of co-investigators in the project: 8

Call: MAESTRO 3 - announced on 2012-06-15

Amount awarded: 2 988 100 PLN

Project start date (Y-m-d): 2013-04-22

Project end date (Y-m-d): 2018-11-21

Project duration:: 67 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. mikroskop.
  2. bieżnia do badania wydolności mięśni myszy (80 000 PLN)

Information in the final report

  • Publication in academic press/journals (24)
  1. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
    Authors:
    Łoboda Agnieszka , Damulewicz M, Pyza E, Józkowicz Alicja , Dulak Józef
    Academic press:
    3.Cellular and Molecular Life Sciences (rok: 2016, tom: 73, strony: 3221-47), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-016-2223-0 - link to the publication
  2. Heme Oxygenase-1 influences satellite cells and progression of Duchenne muscular dystrophy in mice.
    Authors:
    Pietraszek-Gremplewicz K, Kozakowska M, Bronisz-Budzynska I, Ciesla M, Mucha O, Podkalicka P, Madej M, Glowniak U, Szade K, Stepniewski J, Jez M, Andrysiak K, Bukowska-Strakova K, Kaminska A, Kostera-Pruszczyk A, Jozkowicz A, Loboda A, Dulak J.
    Academic press:
    Antioxidants and Redox Sigaling (rok: 2018, tom: 29, strony: 128-148), Wydawca: Mary Ann Libert INc
    Status:
    Published
    DOI:
    10.1089/ars. - link to the publication
  3. Heme oxygenase-1 affects generation and spontaneous cardiac differentiation of induced pluripotent stem cells.
    Authors:
    Stepniewski J, Pacholczak T, Skrzypczyk A, Ciesla M, Szade A, Szade K, Bidanel R, Langrzyk A, Grochowski R, Vandermeeren F, Kachamakova-Trojanowska N, Jez M, Drabik G, Nakanishi M, Jozkowicz A, Dulak J.
    Academic press:
    IUBMB Life. (rok: 2018, tom: 70, strony: 129-142), Wydawca: Wiley, International Union of Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1002/iub.1711 - link to the publication
  4. Single-Cell RNA-Sequencing and Metabolomics Analyses Reveal the Contribution of Perivascular Adipose Tissue Stem Cells to Vascular Remodeling.
    Authors:
    Gu W, Nowak WN, Xie Y, Le Bras A, Hu Y, Deng J, Issa Bhaloo S, Lu Y, Yuan H, Fidanis E, Saxena A, Kanno T, Mason AJ, Dulak J, Cai J, Xu Q.
    Academic press:
    Arterioscler Thromb Vasc Biol (rok: 2019, tom: Epub, strony: 2019 Jul 25), Wydawca: American Heart Association
    Status:
    Published
    DOI:
    10.1161/ATVBAHA.119.312732 - link to the publication
  5. Novel faces of heme oxygenase-1: mechanisms and therapeutic potentials
    Authors:
    Józef Dulak, Alicja Józkowicz
    Academic press:
    Antioxidants & Redox Signaling (rok: 2014, tom: 20, strony: 1673-1676), Wydawca: Mary Ann Liebert, Inc
    Status:
    Published
    DOI:
    10.1089/ars.2013.5761 - link to the publication
  6. Targeting angiogenesis in Duchenne muscular dystroophy
    Authors:
    Podkalicka P, Mucha O, Dulak J, Loboda A.
    Academic press:
    Cell Mol Life Sci. (rok: 2019, tom: 76, strony: 1507-1528), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03006-7 - link to the publication
  7. The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
    Authors:
    Krist Bart, Florczyk Urszula, Pietraszek-Gremplewicz Katarzyna, Józkowicz Alicja, Dulak Józef
    Academic press:
    International Journal of Endocrinology (rok: 2015, tom: 2015, strony: 2015:281756), Wydawca: Hindawi Press
    Status:
    Published
    DOI:
    10.1155/2015/281756. - link to the publication
  8. The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes.
    Authors:
    Kozakowska M, Pietraszek-Gremplewicz K, Jozkowicz A, Dulak J.
    Academic press:
    J Muscle Res Cell Motil (rok: 2015, tom: 36, strony: 377-393), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10974-015-9438-9 - link to the publication
  9. The Role of miR-378a in Metabolism, Angiogenesis, and Muscle Biology
    Authors:
    Krist Bart, Florczyk Urszula, Pietraszek-Gremplewicz Katarzyna, Józkowicz Alicja, Dulak Józef
    Academic press:
    International Journal of Endocrinology (rok: 2015, tom: 2015, strony: 2015:281756), Wydawca: Hindawi Press
    Status:
    Published
    DOI:
    10.1155/2015/281756. - link to the publication
  10. Novel faces of heme oxygenase-1: mechanisms and therapeutic potentials
    Authors:
    Józef Dulak, Alicja Józkowicz
    Academic press:
    Antioxidants & Redox Signaling (rok: 2014, tom: 20, strony: 1673-1676), Wydawca: Mary Ann Liebert, Inc
    Status:
    Published
    DOI:
    10.1089/ars.2013.5761 - link to the publication
  11. Mięśniowe komórki progenitorowe - charakterystyka i funkcja.
    Authors:
    Kozakowska M, Dulak J, Józkowicz A.
    Academic press:
    Postępy Biologii Komórki (rok: 2015, tom: 42 (3), strony: 465-490), Wydawca: Polskie Towarzystwo Biologii Komórki
    Status:
    Published
    DOI:
    brak - link to the publication
  12. Oksygenaza hemowa-1 – więcej niż cytoprotekcja/Heme oxygenase-1 - more than the cytoprotection
    Authors:
    Kozakowska Magdalena, Dulak Józef, Józkowicz Alicja.
    Academic press:
    Postępy Biochemii (rok: 2015, tom: 61, strony: 147-158), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
  13. The role of oxidative stress in skeletal muscle injury and regeneration: focus on antioxidant enzymes.
    Authors:
    Kozakowska M, Pietraszek-Gremplewicz K, Jozkowicz A, Dulak J.
    Academic press:
    J Muscle Res Cell Motil (rok: 2015, tom: 36, strony: 377-393), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s10974-015-9438-9 - link to the publication
  14. Mięśniowe komórki progenitorowe - charakterystyka i funkcja.
    Authors:
    Kozakowska M, Dulak J, Józkowicz A.
    Academic press:
    Postępy Biologii Komórki (rok: 2015, tom: 42 (3), strony: 465-490), Wydawca: Polskie Towarzystwo Biologii Komórki
    Status:
    Published
  15. Lack of Heme Oxygenase-1 Induces Inflammatory Reaction and Proliferation of Muscle Satellite Cells after Cardiotoxin-Induced Skeletal Muscle Injury.
    Authors:
    Kozakowska M, Pietraszek-Gremplewicz K, Ciesla M, Seczynska M, Bronisz-Budzynska I, Podkalicka P, Bukowska-Strakova K, Loboda A, Jozkowicz A, Dulak J.
    Academic press:
    American Journal of Pathology (rok: 2018, tom: 188, strony: 491-506), Wydawca: Elsevier, American Society for Investigative Pathology
    Status:
    Published
    DOI:
    10.017 - link to the publication
  16. Role of Nrf2/HO-1 system in development, oxidative stress response and diseases: an evolutionarily conserved mechanism
    Authors:
    Łoboda Agnieszka , Damulewicz M, Pyza E, Józkowicz Alicja , Dulak Józef
    Academic press:
    3.Cellular and Molecular Life Sciences (rok: 2016, tom: 73, strony: 3221-47), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-016-2223-0 - link to the publication
  17. Oksygenaza hemowa-1 – więcej niż cytoprotekcja/Heme oxygenase-1 - more than the cytoprotection
    Authors:
    Kozakowska Magdalena, Dulak Józef, Józkowicz Alicja.
    Academic press:
    Postępy Biochemii (rok: 2015, tom: 61, strony: 147-158), Wydawca: Polskie Towarzystwo Biochemiczne
    Status:
    Published
    DOI:
    brak - link to the publication
  18. Targeting angiogenesis in Duchenne muscular dystroophy
    Authors:
    Podkalicka P, Mucha O, Dulak J, Loboda A.
    Academic press:
    Cell Mol Life Sci. (rok: 2019, tom: 76, strony: 1507-1528), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00018-019-03006-7 - link to the publication
  19. Heme Oxygenase-1 influences satellite cells and progression of Duchenne muscular dystrophy in mice.
    Authors:
    Pietraszek-Gremplewicz K, Kozakowska M, Bronisz-Budzynska I, Ciesla M, Mucha O, Podkalicka P, Madej M, Glowniak U, Szade K, Stepniewski J, Jez M, Andrysiak K, Bukowska-Strakova K, Kaminska A, Kostera-Pruszczyk A, Jozkowicz A, Loboda A, Dulak J.
    Academic press:
    Antioxidants and Redox Sigaling (rok: 2018, tom: 29, strony: 128-148), Wydawca: Mary Ann Libert INc
    Status:
    Published
    DOI:
    10.1089/ars. - link to the publication
  20. miR-146a deficiency does not aggravate muscular dystrophy in mdx mice.
    Authors:
    Bronisz-Budzyńska I, Chwalenia K, Mucha O, Podkalicka P, Karolina-Bukowska-Strakova, Józkowicz A, Łoboda A, Kozakowska M, Dulak J.
    Academic press:
    Skeletal Muscle (rok: 2019, tom: 9, strony: 22), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13395-019-0207-0. - link to the publication
  21. Adult stem cells: hopes and hypes of regenerative medicine.
    Authors:
    Dulak Jozef, Szade Krzysztof, Szade Agata, Nowak Witold, Józkowicz Alicja.
    Academic press:
    Acta Biochimica Polonica (rok: 2015, tom: 62, strony: 329-337), Wydawca: Polish Biochemical Society
    Status:
    Published
    DOI:
    10.18388/abp.2015_1023 - link to the publication
  22. miR-146a deficiency does not aggravate muscular dystrophy in mdx mice.
    Authors:
    Bronisz-Budzyńska I, Chwalenia K, Mucha O, Podkalicka P, Karolina-Bukowska-Strakova, Józkowicz A, Łoboda A, Kozakowska M, Dulak J.
    Academic press:
    Skeletal Muscle (rok: 2019, tom: 9, strony: 22), Wydawca: BMC
    Status:
    Published
    DOI:
    10.1186/s13395-019-0207-0. - link to the publication
  23. Valproic acid downregulates heme oxygenase-1 independently of Nrf2 by increasing ubiquitination and proteasomal degradation.
    Authors:
    Jez M, Ciesla M, Stepniewski J, Langrzyk A, Muchova L, Vitek L, Jozkowicz A, Dulak J.
    Academic press:
    Biochem Biophys Res Commun. (rok: 2017, tom: 485, strony: 1601-166), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2017.02.041. - link to the publication
  24. Valproic acid downregulates heme oxygenase-1 independently of Nrf2 by increasing ubiquitination and proteasomal degradation.
    Authors:
    Jez M, Ciesla M, Stepniewski J, Langrzyk A, Muchova L, Vitek L, Jozkowicz A, Dulak J.
    Academic press:
    Biochem Biophys Res Commun. (rok: 2017, tom: 485, strony: 1601-166), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2017.02.041. - link to the publication

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