Projects funded by the NCN

Information on the principal investigator and host institution

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Voivodeship

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The effect of reductive activation of antitumour anthracycline antibiotics and their synthetic analogues on restoring cytostatic activity towards multidrug resistant cells originating from solid tumours

2012/05/B/NZ3/01985

Keywords:

antitumour anthracycline drugs synthetic anthracycline analogues CPR-dependent reductive activation solid tumour cells breast cancer MCF7 cell line colon cancer LoVo cell line

Descriptors:

NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Szczeciński, Wydział Biologii

woj. zachodniopomorskie

Other projects carried out by the institution

Principal investigator (from the host institution):

prof. Jolanta Tarasiuk

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 297 000 PLN

Project start date (Y-m-d): 2013-02-13

Project end date (Y-m-d): 2016-02-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

System do bankowania komórek nowotworowych (40 000 PLN)
Zestaw pipet automatycznych.
Układ do pomiarów spektrofluorymetrycznych w nanoobjętościach (10 000 PLN)

Information in the final report

Publication in academic press/journals (1)
Articles in post-conference publications (5)

DNA damage induced by NADPH cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells
Authors:
Wojciech Żwierełło, Agnieszka Maruszewska, Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
Academic press:
Pharmacological Reports (rok: 2017, tom: 69, strony: 185-195), Wydawca: Institute of Pharmacology of the Polish Academy of Sciences, Elsevier
Status:
Published
DOI:
10.002 - link to the publication

Effect of reductive activation of idarubicin by NADPH cytochrome P450 reductase on its intracellular accumulation in sensitive and multidrug resistant MCF7 breast cancer cells
Authors:
Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
Conference:
XVIIth Gliwice Scientific Meetings (rok: 2013, ), Wydawca: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
Data:
konferencja 15.11-16.11
Status:
Published
DOI:
link to the publication
DNA double-strand breaks induced by NADPH cytochrome P450 reductase-activated mitoxantrone in sensitive and multidrug resistant LoVo colon cancer cells.
Authors:
Wojciech Żwierełło, Agnieszka Maruszewska, Jolanta Tarasiuk
Conference:
XIXth Gliwice Scientific Meetings (rok: 2015, ), Wydawca: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
Data:
konferencja 20.11.-21.11.
Status:
Published
DOI:
link to the publication
Effect of reductive activation of antitumour anthracycline drugs by NADPH cytochrome P450 reductase on their intracellular accumulation in sensitive LoVo and multidrug resistant LoVo/DX colon cancer cells
Authors:
Robert Nowak, Wojciech Żwierełło, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
Conference:
9th International Conference of Anticancer Research (rok: 2014, ), Wydawca: International Institute of Anticancer Research, Stanford University HighWire Press
Data:
konferencja 6.10-10.10
Status:
Published
DOI:
link to the publication
Effect of reductive activation of doxorubicin by NADPH cytochrome P450 reductase on cell cycle of sensitive and multidrug resistant MCF7 breast cancer cells
Authors:
Wojciech Żwierełło, Robert Nowak, Dorota Kostrzewa-Nowak, Agnieszka Maruszewska, Jolanta Tarasiuk
Conference:
XVIIIth Gliwice Scientific Meetings (rok: 2014, ), Wydawca: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
Data:
konferencja 21.11-22.11
Status:
Published
DOI:
link to the publication
DNA damage induced by NADPH Cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells.
Authors:
Wojciech Żwierełło, Agnieszka Maruszewska, Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
Conference:
The 42nd Congress of the International Society of Oncology and Biomarkers (rok: 2015, ), Wydawca: Tumor Biology, International Society of Oncology and BioMarkers, Springer Science+Business Media B.V.
Data:
konferencja 3.10-7.10.
Status:
Published

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

The effect of reductive activation of antitumour anthracycline antibiotics and their synthetic analogues on restoring cytostatic activity towards multidrug resistant cells originating from solid tumours

Equipment purchased [PL]

Information in the final report

O Narodowym Centrum Nauki

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Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

The effect of reductive activation of antitumour anthracycline antibiotics and their synthetic analogues on restoring cytostatic activity towards multidrug resistant cells originating from solid tumours

Equipment purchased [PL]

Information in the final report

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Partnerzy