Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The effect of reductive activation of antitumour anthracycline antibiotics and their synthetic analogues on restoring cytostatic activity towards multidrug resistant cells originating from solid tumours

2012/05/B/NZ3/01985

Keywords:

antitumour anthracycline drugs synthetic anthracycline analogues CPR-dependent reductive activation solid tumour cells breast cancer MCF7 cell line colon cancer LoVo cell line

Descriptors:

  • NZ3_1: Cell biology

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Uniwersytet Szczeciński, Wydział Biologii

woj. zachodniopomorskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jolanta Tarasiuk 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 297 000 PLN

Project start date (Y-m-d): 2013-02-13

Project end date (Y-m-d): 2016-02-12

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. System do bankowania komórek nowotworowych (40 000 PLN)
  2. Zestaw pipet automatycznych.
  3. Układ do pomiarów spektrofluorymetrycznych w nanoobjętościach (10 000 PLN)

Information in the final report

  • Publication in academic press/journals (1)
  • Articles in post-conference publications (5)
  1. DNA damage induced by NADPH cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells
    Authors:
    Wojciech Żwierełło, Agnieszka Maruszewska, Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Academic press:
    Pharmacological Reports (rok: 2017, tom: 69, strony: 185-195), Wydawca: Institute of Pharmacology of the Polish Academy of Sciences, Elsevier
    Status:
    Published
    DOI:
    10.002 - link to the publication
  1. Effect of reductive activation of idarubicin by NADPH cytochrome P450 reductase on its intracellular accumulation in sensitive and multidrug resistant MCF7 breast cancer cells
    Authors:
    Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Conference:
    XVIIth Gliwice Scientific Meetings (rok: 2013, ), Wydawca: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
    Data:
    konferencja 15.11-16.11
    Status:
    Published
    DOI:
    link to the publication
  2. DNA double-strand breaks induced by NADPH cytochrome P450 reductase-activated mitoxantrone in sensitive and multidrug resistant LoVo colon cancer cells.
    Authors:
    Wojciech Żwierełło, Agnieszka Maruszewska, Jolanta Tarasiuk
    Conference:
    XIXth Gliwice Scientific Meetings (rok: 2015, ), Wydawca: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
    Data:
    konferencja 20.11.-21.11.
    Status:
    Published
    DOI:
    link to the publication
  3. Effect of reductive activation of antitumour anthracycline drugs by NADPH cytochrome P450 reductase on their intracellular accumulation in sensitive LoVo and multidrug resistant LoVo/DX colon cancer cells
    Authors:
    Robert Nowak, Wojciech Żwierełło, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Conference:
    9th International Conference of Anticancer Research (rok: 2014, ), Wydawca: International Institute of Anticancer Research, Stanford University HighWire Press
    Data:
    konferencja 6.10-10.10
    Status:
    Published
    DOI:
    link to the publication
  4. Effect of reductive activation of doxorubicin by NADPH cytochrome P450 reductase on cell cycle of sensitive and multidrug resistant MCF7 breast cancer cells
    Authors:
    Wojciech Żwierełło, Robert Nowak, Dorota Kostrzewa-Nowak, Agnieszka Maruszewska, Jolanta Tarasiuk
    Conference:
    XVIIIth Gliwice Scientific Meetings (rok: 2014, ), Wydawca: Association for the Support of Cancer Research, Maria Skłodowska-Curie Memorial Cancer Center and Institute of Oncology, Gliwice Branch Silesian University of Technology
    Data:
    konferencja 21.11-22.11
    Status:
    Published
    DOI:
    link to the publication
  5. DNA damage induced by NADPH Cytochrome P450 reductase-activated idarubicin in sensitive and multidrug resistant MCF7 breast cancer cells.
    Authors:
    Wojciech Żwierełło, Agnieszka Maruszewska, Robert Nowak, Dorota Kostrzewa-Nowak, Jolanta Tarasiuk
    Conference:
    The 42nd Congress of the International Society of Oncology and Biomarkers (rok: 2015, ), Wydawca: Tumor Biology, International Society of Oncology and BioMarkers, Springer Science+Business Media B.V.
    Data:
    konferencja 3.10-7.10.
    Status:
    Published

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