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Information on the principal investigator and host institution

Information of the project and the call

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The study of mechanisms that enhance the antitumor activity of 5-FU by the use of vitamin D analogs in human colon cancer model

2012/05/N/NZ5/00883

Keywords:

vitamin D analogs 5-fluorouracil colon cancer combined treatment anticancer therapy

Descriptors:

  • NZ5_7: Human disease treatment

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Instytut Immunologii i Terapii Doświadczalnej im. Ludwika Hirszfelda PAN

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Magdalena Milczarek 

Number of co-investigators in the project: 2

Call: PRELUDIUM 3 - announced on 2012-03-15

Amount awarded: 150 000 PLN

Project start date (Y-m-d): 2013-01-31

Project end date (Y-m-d): 2016-09-30

Project duration:: 44 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Tacalcitol increases the sensitivity of colorectal cancer cells to 5-fluorouracil by down-regulation of thymidylate synthase
    Authors:
    Magdalena Milczarek, Joanna Rossowska, Dagmara Kłopotowska, Martyna Stachowicz, Andrzej Kutner, Joanna Wietrzyk
    Academic press:
    Molecular Cancer (rok: 2018, tom: -, strony: -), Wydawca: BMC
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Vitamin D analogs combined with 5-fluorouracil in human HT-29 colon cancer treatment
    Authors:
    Magdalena Milczarek, Beata Filip-Psurska, Wiesław Świętnicki, Andrzej Kutner, Joanna Wietrzyk
    Academic press:
    ONCOLOGY REPORTS (rok: 2014, tom: 32, strony: 491-504), Wydawca: Spandidos Publications
    Status:
    Published
    DOI:
    10.3892/or.2014.3247 - link to the publication
  1. Tacalcitol (1,24-dihydroxyvitamin D3) enhances 5-fluorouracil activity by suppressing the thymidylate synthase expression in the colon cancer cells HT-29
    Authors:
    M. Milczarek, D. Kłopotowska, A. Kutner and J. Wietrzyk
    Conference:
    The Tenth Multidisciplinary Conference on Drug Research (rok: 2016, ), Wydawca: Pharmaceutical Research Institute
    Data:
    konferencja 15-19 May 2016
    Status:
    Published
  2. Vitamin D analogs re-sensitize 5-FU-resistant HT-29 colon cancer cells to this anticancer drug
    Authors:
    M. Milczarek, M. Starostecka, A. Pawlik, A. Anisiewicz, A. Kutner and J. Wietrzyk
    Conference:
    19th Workshop on Vitamin D (rok: 2016, ), Wydawca: Organizers of Vitamin D Workshop
    Data:
    konferencja 29-31 March 2016
    Status:
    Published

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