Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The study of the role of mGluR8 in cancer cells - a potential target for new antitumor strategies

2012/05/B/NZ3/00452

Keywords:

neuroblastoma glioma mGluR8 siRNA antitumor drugs

Descriptors:

  • NZ3_1: Cell biology
  • NZ3_3: Apoptosis

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Farmakologii PAN

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Danuta Jantas 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 324 226 PLN

Project start date (Y-m-d): 2013-02-11

Project end date (Y-m-d): 2015-12-10

Project duration:: 34 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator do hodowli komórkowych z opcją sterylizacji w wysokiej temperaturze (40 000 PLN)
  2. System próżniowy do odsysania cieczy w hodowlach komórkowych (3 500 PLN)
  3. Automatyczny licznik komórek (25 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (1)
  1. Tumor suppressor and chemosensitizer properties of metabotropic glutamate receptor 8 (mGluR8) in human neuroblastoma SH-SY5Y cells: implications for other cancer types
    Authors:
    Danuta Jantas, Beata Grygier, Sławomir Gołda, Justyna Zatorska, Magdalena Tertil
    Academic press:
    Oncotarget , Wydawca: Impact Journals
    Status:
    Submitted
    DOI:
    brak - link to the publication
  2. Neuroprotective effects of mGluR II and III activators against staurosporine- and doxorubicin-induced cellular injury in SH-SY5Y cells: New evidence for a mechanism involving inhibition of AIF translocation.
    Authors:
    Jantas D, Greda A, Leskiewicz M, Grygier B, Pilc A, Lason W.
    Academic press:
    Neurochem Int. (rok: 2015, tom: brak, strony: brak), Wydawca: Elsevier Ltd.
    Status:
    Published
    DOI:
    10.1016/j.neuint.2014.12.011 - link to the publication
  1. The metabotropic glutamate receptor 8 (mGluR8) positive allosteric modulator - AZ12216052 attenuates the chemotherapeutics-induced cell death in human neuroblastoma SH-SY5Y cells
    Authors:
    Danuta Jantas, Beata Grygier, Anna Gręda, Władysław Lasoń
    Conference:
    Neurochemical Conference 2013 "Emerging topics in neurological diseases: molecular mechanisms, diagnosis and therapy" (rok: 2013, ), Wydawca: Materiały zjazdowe
    Data:
    konferencja 24-25.10.2013
    Status:
    Published

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