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Information on the principal investigator and host institution

Information of the project and the call

Keywords

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The role of Parkin in exogenous Alpha-synuclein-induced cell death. Implications for pathogenesis of Parkinson's disease and other synucleinopathies.

2012/05/B/NZ3/02047

Keywords:

Parkin alpha-synuclein Tau cytoskeleton cytotoxicity tau-kinases

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_7: Signal transduction

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agata Adamczyk 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 450 200 PLN

Project start date (Y-m-d): 2013-02-11

Project end date (Y-m-d): 2016-02-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Komputer z oprogramowaniem GraphPad (7 000 PLN)
  2. System do transfekcji (elektroporacji); (35 000 PLN)

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (13)
  1. Extracellular α-synuclein leads to microtubule destabilization via GSK-3β-dependent Tau phosphorylation in PC12 cells
    Authors:
    Gąssowska M, Czapski GA, Pająk B, Cieślik M, Lenkiewicz AM, Adamczyk A.
    Academic press:
    PLoS One. (rok: 2014, tom: 9(4), strony: e94259), Wydawca: Public Library Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0094259 - link to the publication
  2. Extracellular alpha-synuclein induces calpain-dependent overactivation of cyclin-dependent kinase 5 in vitro.
    Authors:
    Czapski GA, Gąssowska M, Wilkaniec A, Cieślik M, Adamczyk A.
    Academic press:
    FEBS Lett. (rok: 2013, tom: 587(18), strony: 3135-3141), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.febslet.2013.07.053. - link to the publication
  3. Potent effects of alkaloid- rich extract from Huperzia selago against sodium nitroprusside-evoked PC 12 cells damage via attenuation of oxidative stress and apoptosis.
    Authors:
    Anna Lenkiewicz, Grzegorz Czapski, Henryk Jęśko, Anna Wilkaniec, Wojciech Szypuła, Agnieszka Pietrosiuk, Agata Adamczyk
    Academic press:
    Folia Neuropathol. (rok: 2016, tom: 54(2), strony: 156-166), Wydawca: Termedia
    Status:
    Published
    DOI:
    10.5114/fn.2016.60361 - link to the publication
  1. Effect of α-synuclein oligomers on Parkin expression in PC12 cells. Relevance to Parkinson's disease.
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec and Agata Adamczyk
    Conference:
    8th Intl Symposium on Neuroprotection Neurorepair (rok: 2014, ), Wydawca: książka abstraktów
    Data:
    konferencja 8-12.04.2014
    Status:
    Published
  2. Extracellular alpha-synuclein induces calpain-dependent overactivation of Cyclin-dependent kinase 5 in PC12 cells.
    Authors:
    Adamczyk Agata, Gąssowska Magdalena, Wilkaniec Anna, Cieślik Magdalena, Czapski Grzegorz A
    Conference:
    11th International Congress, Polish Neuroscience Society, (rok: 2013, ), Wydawca: Acta Neurobiol. Exp. 2013,73, P1.1 Suppl
    Data:
    konferencja September 15-17, 2013 , Poznań
    Status:
    Published
  3. Extracellular α-synuclein and its role in nitrosative stress, mitochondrial dysfunction and neurodegeneration
    Authors:
    Anna Wilkaniec, Agata Adamczyk, Joanna B. Strosznajder.
    Conference:
    Neurochemical Conference 2013 "Emerging topics in neurological diseases: molecular mechanisms, diagnosis and therapy." (rok: 2013, ), Wydawca: Termedia/Folia Neurophatol. 2013, 51, 4, 379
    Data:
    konferencja Oct. 24-25, 2013, Warszawa
    Status:
    Published
    DOI:
    link to the publication
  4. The role of purinergic receptors in alpha synuclein mediated mitochondrial dysfunction and dopaminergic cell death.
    Authors:
    Anna Wilkaniec, Grzegorz A. Czapski, Agata Adamczyk
    Conference:
    7th International Symposium on Experimental and Clinical Neurobiology (rok: 2013, ), Wydawca: Slovak Academy of Sciences
    Data:
    konferencja June 23-27,2013 Kosice, Slovakia.
    Status:
    Published
  5. Oxidative/nitrosative stress evoked by α-Synuclein oligomers lead to post-translational Parkin modification in PC12 cells.
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec and Agata Adamczyk.
    Conference:
    10th Warsaw Intl Medical Congress (rok: 2014, ), Wydawca: Arch. Med. Sci
    Data:
    konferencja 15-18.05.2014
    Status:
    Published
  6. The role of glycogen synthase kinase-3 beta in alpha-synuclein-evoked tau phosphorylation.
    Authors:
    Magdalena Gąssowska, Grzegorz A. Czapski, Agata Adamczyk
    Conference:
    11th International Congress, Polish Neuroscience Society (rok: 2013, ), Wydawca: Acta Neurobiol.Exp.73,P6.5,Suppl.
    Data:
    konferencja September 15-17, 2013 , Poznań
    Status:
    Published
  7. Parkinson's disease related nitrosative stress affects the expression of Parkin and PC12 cell viability.
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    Neurochemical Conference 2013 "Emerging topics in neurological diseases: molecular mechanisms, diagnosis and therapy." (rok: 2013, ), Wydawca: Termedia/Folia Neurophatol. 2013, 51, 4, 392.
    Data:
    konferencja Oct. 24-25, 2013,
    Status:
    Published
    DOI:
    link to the publication
  8. S-nitrosylation of Parkin as a novel regulator of extracellular alpha-synuclein evoked dopaminergic cell death
    Authors:
    Anna M. Lenkiewicz1, Anna Wilkaniec1, Kristina Friedland2 and Agata Adamczyk1
    Conference:
    The 12th International Congress on Alzheimer's & Parkinson's Diseases Mechanisms, clinical strategies and promising treatments of neurodegenerative diseases", Nice, France. (rok: 2015, ), Wydawca: Karger, Neurodegener Dis 2015;15:(suppl 1): 352-1969,1252
    Data:
    konferencja 18-22 Mar, 2015
    Status:
    Published
  9. Alkaloids from Huperziaselago protect dopaminergic PC12 cells against sodium nitroprusside-evoked oxidative stress, mitochondrial dysfunction and apoptosis..
    Authors:
    •Anna M. Lenkiewicz, Grzegorz A. Czapski, Anna Wilkaniec, Wojciech Szypuła and Agata Adamczyk
    Conference:
    Neurochemical conference 2015 Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases. From biomarkers to therapeutics" Warsaw, Poland. (rok: 2015, ), Wydawca: TERMEDIA PUBLISHING HOUSE LTD, Folia Neuropathol. 2015,53,4,p.424,B25.
    Data:
    konferencja 22-23 October 2015,
    Status:
    Published
    DOI:
    link to the publication
  10. Alkaloids of Huperziaselago protect PC12 cells against alpha-synuclein-induced cell damage: involvement of anti-oxidant and anti-apoptotic properties
    Authors:
    Lenkiewicz A, Adamczyk A, Wilkaniec A
    Conference:
    EMBO/EMBL Symposium "Mechanisms of neurodegeneration" Heidelberg, Germany (rok: 2015, ), Wydawca: EMBO/EMBL
    Data:
    konferencja 14-17 June 2015
    Status:
    Published
  11. The involvement of purinergic signaling in mitochondria dysfunction induced by alpha-synuclein.
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec, Agata Adamczyk
    Conference:
    12th International Congress of the Polish Neuroscience Society, Gdańsk, Poland (rok: 2015, ), Wydawca: Nencki Inst. Experimental Biol.,Acta Neurobiol. Exp.75,2015 Suppl. S99,P.14.3
    Data:
    konferencja 6-8 Sep. 2015
    Status:
    Published
    DOI:
    link to the publication
  12. Extracellular alpha-synuclein-evoked parkin deregulation promotes Tau phosphorylation and dopaminergic PC12 cells death.
    Authors:
    Adamczyk A, Lenkiewicz A, Wilkaniec A, Gąssowska M
    Conference:
    The 12th International Congress on Alzheimer's & Parkinson's Diseases Mechanisms, clinical strategies and promising treatments of neurodegenerative diseases" Nice, France. (rok: 2015, ), Wydawca: Karger, Neurodegener Dis 2015,15 (Suppl 1),352-1969.
    Data:
    konferencja 18-22 Mar, 2015
    Status:
    Published
  13. Extracellular oligomers of alpha-Synuclein induces Parkin modifications and dopaminergic PC12 cells death
    Authors:
    Anna M. Lenkiewicz, Anna Wilkaniec and Agata Adamczyk
    Conference:
    27th ECNP Congress (rok: 2014, ), Wydawca: ECNP
    Data:
    konferencja 18-21.10.2014
    Status:
    Published

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