Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

Physiological and toxicological aspects of the aryl hydrocarbon receptor (AhR) activation in the regulation of granulosa cell function in pigs.

2012/05/B/NZ9/03333

Keywords:

pig AhR TCDD proteomics genomics granulosa cells reproduction gene silencing microarrays

Descriptors:

  • NZ9_2: Animal production
  • NZ2_2: Genomics, transcriptomics, epigenomics
  • NZ2_3: Proteomics

Panel:

NZ9 - Fundamentals of applied life sciences and biotechnology: agricultural, forestry, horticulture, animal production and fishery, food and nutrition sciences, industrial biosciences, environmental biotechnology and remediation

Host institution :

Uniwersytet Warmińsko-Mazurski w Olsztynie, Wydział Biologii i Biotechnologii

woj. warmińsko-mazurskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Renata Ciereszko 

Number of co-investigators in the project: 5

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 855 400 PLN

Project start date (Y-m-d): 2013-03-14

Project end date (Y-m-d): 2016-12-13

Project duration:: 45 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (8)
  • Articles in post-conference publications (14)
  1. Characterization of porcine granulosa cell line AVG-16
    Authors:
    Sadowska A., Nynca A., Korzeniewska M., Piasecka-Srader J., Jablonska M., Orlowska K., Swigonska S., Ciereszko R.E.
    Academic press:
    Folia Biologica (Praha) (rok: 2015, tom: 61, strony: 184-194), Wydawca: Charles University in Prague - First Faculty of Medicine
    Status:
    Published
    DOI:
    brak - link to the publication
  2. Is CYP1B1 involved in the metabolism of dioxins in the pig?
    Authors:
    Tomasz Molcan; Sylwia Swigonska; Anna Nynca; Agnieszka Sadowska; Monika Ruszkowska; Karina Orlowska; Renata E Ciereszko
    Academic press:
    Biochimica et Biophysica Acta General Subjects , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  3. Structural-functional adaptations of porcine CYP1A1 to metabolize polychlorinated dibenzo-p-dioxins
    Authors:
    Molcan T., Swigonska S., Orlowska K., Myszczynski K., Nynca A., Sadowska A., Ruszkowska M., Jastrzebski J.P., Ciereszko R.E.
    Academic press:
    Chemosphere (rok: 2017, tom: 168, strony: 205-216), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.035 - link to the publication
  4. The tertiary structures of porcine AhR and ARNT proteins and molecular interactions within the TCDD/AhR/ARNT complex
    Authors:
    Orlowska K., Molcan T., Swigonska S., Sadowska A., Jablonska M., Nynca A., Ciereszko R.E.
    Academic press:
    Journal of Molecular Graphics and Modelling (rok: 2016, tom: 67, strony: 119-126), Wydawca: Molecular Graphics and Modelling Society; American Chemical Society. Division of Computers in Chemistry, Elsevier
    Status:
    Published
    DOI:
    10.1016/j.jmgm.2016.05.012 - link to the publication
  5. Transcript variations, phylogenetic tree and chromosomal localization of porcine aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (ARNT) genes
    Authors:
    Sadowska A., Paukszto L., Nynca A., Szczerbal I., Orlowska K., Swigonska S., Jablonska M., Molcan T., Jastrzebski J.P., Panasiewicz G., Ciereszko R.E.
    Academic press:
    Journal of Genetics (rok: 2017, tom: 96, strony: 75-85), Wydawca: Indian Academy of Sciences
    Status:
    Published
    DOI:
    10.1007/s12041-017-0745-3 - link to the publication
  6. Transcriptional profiling of porcine granulosa cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin
    Authors:
    Sadowska A., Nynca A., Ruszkowska M., Paukszto L., Myszczynski K., Orlowska K., Swigonska S., Molcan T., Jastrzebski J.P., Ciereszko R.E.
    Academic press:
    Chemosphere (rok: 2017, tom: 178, strony: 368-377), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.chemosphere.2017.03.055 - link to the publication
  7. Identification and characterization of long non-coding RNAs in porcine granulosa cells exposed to TCDD
    Authors:
    Ruszkowska Monika, Nynca Anna, Paukszto Lukasz, Sadowska Agnieszka, Swigonska Sylwia, Orlowska Karina, Molcan Tomasz, Jastrzebski Jan, Ciereszko Renata E.
    Academic press:
    Journal of Animal Science and Biotechnology , Wydawca: Springer
    Status:
    Submitted
    DOI:
    brak - link to the publication
  8. The effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on the proteome of porcine granulosa cells
    Authors:
    Karina Orlowska; Sylwia Swigonska; Agnieszka Sadowska; Monika Ruszkowska; Anna Nynca; Tomasz Molcan; Renata E Ciereszko
    Academic press:
    Chemosphere , Wydawca: Elsevier
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Homology modeling of ligand binding domain of the porcine aryl hydrocarbon receptor (AHR-LBD) and in silico analysis of the interactions between AhR and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD).
    Authors:
    Orlowska K., Molcan T., Sadowska A., Jablonska M., Swigonska S., Nynca A., Jastrzebski J.P., Ciereszko R.E.
    Conference:
    11th International Conference on Animal Physiology (rok: 2015, ), Wydawca: Slovak University of Agriculture in Nitra
    Data:
    konferencja 01-03.06
    Status:
    Published
  2. The presence of estrogen receptors and aryl hydrocarbon receptor in porcie granulosa cell line AVG-16 and primary granulosa cells
    Authors:
    Jablonska M., Nynca A., Sadowska A., Orlowska K., Swigonska S., Korzeniewska M., Ciereszko R.E.
    Conference:
    XLIX Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików (rok: 2015, ), Wydawca: Pomorski Uniwersytet Medyczny w Szczecinie, Polskie Towarzystwo Histochemików i Cytochemików
    Data:
    konferencja 09-12.09.
    Status:
    Published
  3. Molecular interactios between porcine CYP1A1 and selected dioxins may help to explain the high resistance of TCDD to biodegradation
    Authors:
    Molcan Tomasz, Swigonska Sylwia, Orlowska Karina, Nynca Anna, Sadowska Agnieszka, Ruszkowska Monika, Ciereszko Renata E.
    Conference:
    21st Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) (rok: 2017, ), Wydawca: Reproduction in Domestic Animals, Wiley
    Data:
    konferencja 25-26 Aug
    Status:
    Published
  4. STEROIDOGENESIS AND FSH RECEPTOR EXPRESSION IN AVG-16 CELL LINE
    Authors:
    Kolomycka A., Misiulajtis K., Nynca A., Piasecka J., Korzeniewska M., Jablonska M., Ciereszko RE.
    Conference:
    VII Zjazd Towarzystwa Biologii Rozrodu (rok: 2014, ), Wydawca: Towarzystwo Biologii Rozrodu, Elsevier
    Data:
    konferencja 11-13. 09.2014
    Status:
    Published
  5. Changes in the proteome of porcine granulosa cells induced by TCDD
    Authors:
    Orlowska Karina, Swigonska Sylwia, Sadowska Agnieszka, Ruszkowska Monika, Nynca Anna, Molcan Tomasz, Ciereszko, Renata E.
    Conference:
    21st Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) (rok: 2017, ), Wydawca: Reproduction in Domestic Animals, Wiley
    Data:
    konferencja 25-26 Aug
    Status:
    Published
  6. Characterization, genetic variants and chromosom al localization of the porcine aryl hydrocarbon receptor (AhR) gene
    Authors:
    Sadowska A., Paukszto L., Nynca A., Szczerbal I., Orlowska K., Swigonska S., Jablonska M., Molcan T., Panasiewicz G., Jastrzebski J.P., Ciereszko R.E.
    Conference:
    The 4th Winter Workshop of the Society for Biology of Reproduction Central and Local Regulations of Reproductive Processes" (rok: 2016, ), Wydawca: Towarzystwo Biologii Rozrodu, Elsevier
    Data:
    konferencja 03-05.02.
    Status:
    Published
  7. Comparative analysis of CYP1A1, CYP1A2 and CYP2E1 gene sequences in the pig
    Authors:
    Jablonska M., Paukszto L., Jastrzebski J.P., Swigonska S., Orlowska K., Molcan T., Jaloza N., Nynca A., Sadowska A., Ciereszko R.E.
    Conference:
    The 4th Winter Workshop of the Society for Biology of Reproduction Central and Local Regulations of Reproductive Processes" (rok: 2016, ), Wydawca: Towarzystwo Biologii Rozrodu, Elsevier
    Data:
    konferencja 03-05.02.
    Status:
    Published
  8. Molecular interactions between the porcine AhR and 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
    Authors:
    Swigonska Sylwia, Orlowska Karina, Molcan Tomasz, Nynca Anna, Sadowska Agnieszka, Ruszkowska Monika, Ciereszko Renata E.
    Conference:
    21st Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) (rok: 2017, ), Wydawca: Reproduction in Domestic Animals, Wiley
    Data:
    konferencja 25-26 Aug
    Status:
    Published
  9. 2,3,7,8-tetrachlorodibenzo-p-dioksyna (TCDD) affects the transcriptome of porcine granulosa cells
    Authors:
    Sadowska Agnieszka, Nynca Anna, Paukszto Lukasz, Ruszkowska Monika, Orlowska Karina, Swigonska Sylwia, Molcan Tomasz, Jastrzebski Jan, Ciereszko Renata E.
    Conference:
    21st Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) (rok: 2017, ), Wydawca: Reproduction in Domestic Animals, Wiley
    Data:
    konferencja 25-26 Aug
    Status:
    Published
  10. Molecular basis for AhR-mediated toxicity of environmental pollutants
    Authors:
    Orlowska K., Molcan T., Swigonska S., Sadowska A., Jablonska M., Nynca A., Jastrzebski J.P., Ciereszko R.E.
    Conference:
    The 4th Winter Workshop of the Society for Biology of Reproduction Central and Local Regulations of Reproductive Processes" (rok: 2016, ), Wydawca: Towarzystwo Biologii Rozrodu, Elsevier
    Data:
    konferencja 03-05.02.
    Status:
    Published
  11. Steroidogenesis and LH receptor expression In AVG-16 cells.
    Authors:
    Sadowska A., Jablonska M., Orlowska K., Nynca A., Swigonska S., Ciereszko R.E.
    Conference:
    XLIX Sympozjum Polskiego Towarzystwa Histochemików i Cytochemików (rok: 2015, ), Wydawca: Pomorski Uniwersytet Medyczny w Szczecinie, Polskie Towarzystwo Histochemików i Cytochemików
    Data:
    konferencja 09-12.09.
    Status:
    Published
  12. Next-Generation Sequencing (NGS) and bioinformatic tools for establishing the sequence of porcine aryl hydrocarbon receptor (AhR) gene
    Authors:
    Sadowska A., Orlowska K., Paukszto L., Jablonska M., Swigonska S., Nynca A., Jastrzebski J.P., Ciereszko R.E.
    Conference:
    11th international Conference on Animal Physiology (rok: 2015, ), Wydawca: Slovak University of Agriculture in Nitra
    Data:
    konferencja 01-03.06
    Status:
    Published
  13. Next-Generation Sequencing (NGS) and bioinformatic tools for establishing the sequence of porcine aryl hydrocarbon receptor nuclear translocator (ARNT) gene
    Authors:
    Jablonska M., Paukszto L., Orlowska K., Swigonska S., Sadowska A., Nynca A., Jastrzebski J.P., Ciereszko R.E.
    Conference:
    11th International Conference on Animal Physiology (rok: 2015, ), Wydawca: Slovak University of Agriculture in Nitra
    Data:
    konferencja 01-03.06.
    Status:
    Published
  14. Silencing of the aryl hydrocarbon receptor gene in porcine granulosa cells by using short interfering RNA (siRNA)
    Authors:
    Ruszkowska Monika, Sadowska Agnieszka, Nynca Anna, Orlowska Karina, Swigonska Sylwia, Molcan Tomasz, Ciereszko Renata E.
    Conference:
    21st Annual Conference of the European Society for Domestic Animal Reproduction (ESDAR) (rok: 2017, ), Wydawca: Reproduction in Domestic Animals, Wiley
    Data:
    konferencja 25-26 Aug
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy