Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Helicobacter pylori Dsb (disulfide bond) proteins - analysis of the relations between sequence, structure and function of HP0231 and HP0377

2012/05/B/NZ1/00039

Keywords:

H. pylori disulfide bonds oxidoreductases cytochrome c maturation process virulence

Descriptors:

  • NZ1_10: Microbiology
  • NZ1_1: Molecular biology
  • NZ1_5: Genetic engineering

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Uniwersytet Warszawski, Wydział Biologii

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Elżbieta Jagusztyn-Krynicka 

Number of co-investigators in the project: 6

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 500 000 PLN

Project start date (Y-m-d): 2013-02-12

Project end date (Y-m-d): 2016-02-11

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. AKTA purifing system - firma GE Healthcare Life Sciences (80 000 PLN)
  2. Aparat Trans blot Turbo - uzupełnienie aparatury do oczyszczania białek , opłata części kosztów.

Information in the final report

  • Publication in academic press/journals (8)
  1. Diversity of the Epsilonproteobacteria Dsb (disulfide bond) systems
    Authors:
    Katarzyna Marta Bocian-Ostrzycka, Magdalena Joanna Grzeszczuk, Lukasz Dziewit and Elzbieta Katarzyna Jagusztyn-Krynicka
    Academic press:
    Frontiers in Microbiology, (rok: 2015, tom: 6, strony: 570), Wydawca: Frontiers is a community-rooted, open-access academic publisher
    Status:
    Published
    DOI:
    10.3389/fmicb.2015.00570 - link to the publication
  2. Proces biogenezy cytochromów c w komórkach bakteryjnych - rola białek Dsb (disulfide bond)
    Authors:
    Paula Roszczenko, Magdalena Grzeszczuk, Elżbieta Katarzyna Jagusztyn-Krynicka
    Academic press:
    Postępy Mikrobiologii (rok: 2014, tom: 53, strony: 318 - 327), Wydawca: PTM
    Status:
    Published
  3. Helicobacter pylori HP0231 influences bacterial virulence and is essential for gastric colonization
    Authors:
    Yu Zhong, Florian Anderl, Tobias Kruse, Franziska Schindele, Elżbieta Katarzyna Jagusztyn-Krynicka, Wolfgang Fische, Markus Gerhard and Raquel Mejías-Luque
    Academic press:
    PLos ONE (rok: 2016, tom: 11, strony: 45304), Wydawca: Public Library of Science
    Status:
    Published
    DOI:
    10.1371/journal.pone.0154643. - link to the publication
  4. Detection of Protein Oxidative Activity Using Reduced RNase A
    Authors:
    Magdalena Grzeszczuk, Katarzyna Bocian-Ostrzycka, Anna Lasica and E. Katarzyna Jagusztyn-Krynicka
    Academic press:
    Bio-protocol (rok: 2016, tom: 6, strony: iss 6), Wydawca: e-journal załozony w 2011 przez naukowców ze Stanford Uniwersytetu
    Status:
    Published
  5. Engineering of Helicobacter pylori dimeric oxidoreductase DsbK (HP0231) – the role of catalytic motifs and the N-terminal dimerization domain
    Authors:
    Katarzyna M. Bocian-Ostrzycka, Magdalena J. Grzeszczuk, Anna M. Banaś, Katarzyna Jastrząb, Karolina Pisarczyk, Anna M. Kolarzyk, Anna M. Łasica, Jean-François Collet, Elżbieta K. Jagusztyn-Krynicka
    Academic press:
    Frontiers in Microbiology (rok: 2016, tom: 7, strony: 1158), Wydawca: Frontiers is a community-rooted, open-access academic publisher
    Status:
    Published
    DOI:
    10.3389/fmicb.2016.01158 - link to the publication
  6. Functional and evolutionary analyses of Helicobacter pylori HP0231( DsbK) protein characterized by a highly diverged dimerization domain and strong oxidative and chaperon activities
    Authors:
    Katarzyna M. Bocian-Ostrzycka, Anna M. Łasica, Stanislaw Dunin-Horkawicz, Magdalena Grzeszczuk, Karolina Drabik, Aneta M. Dobosz, Renata Godlewska, Elzbieta Nowak,Jean-Francois Colletb, E. Katarzyna Jagusztyn-Krynicka
    Academic press:
    Frontiers in Microbiology (rok: 2016, tom: 6, strony: 1065), Wydawca: Frontiers is a community-rooted, open-access academic publisher
    Status:
    Published
    DOI:
    10.3389/fmicb.2015.01065 - link to the publication
  7. Helicobacter pylori HP0377, a member of the Dsb family, is an untypical multifunctional CcmG that cooperates with dimeric thioldisulfide oxidase HP0231
    Authors:
    Paula Roszczenko, Magdalena Grzeszczuk, Patrycja Kobierecka, Ewa Wywial, Paweł Urbanowicz, Piotr Wincek, E. Katarzyna Jagusztyn- Krynicka
    Academic press:
    BMC Microbiol. (rok: 2015, tom: 15, strony: 135-153), Wydawca: Bio MedCentral
    Status:
    Published
    DOI:
    10.1186/s12866-015-0471-z - link to the publication
  8. Różnorodność szlaków utleniania Dsb (disulfide bond) w świecie mi,roorganizmów
    Authors:
    Aneta Dobosz, Katarzyna Bocian-Ostrzycka i Elżbieta Katarzyna Jagusztyn-Krynicka
    Academic press:
    Postępy Mikrobiologii (rok: 2015, tom: 1, strony: 21-32), Wydawca: PTM
    Status:
    Published