Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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Iron deficiency and skeletal muscle dysfunction in heart failure

2012/05/E/NZ5/00590

Keywords:

heart failure iron iron deficiency metabolism skeletal muscles

Descriptors:

  • NZ5_7: Human disease treatment
  • NZ5_3: Pathogenesis of human diseases
  • NZ5_5: Diagnostics in human diseases

Panel:

NZ5 - Human and animal noninfectious diseases: etiology, mechanisms, diagnosis and treatment of diseases, poisonings and injuries (without neurological diseases)

Host institution :

Uniwersytet Medyczny im. Piastów Śląskich we Wrocławiu, Wydział Nauk o Zdrowiu

woj. dolnośląskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ewa Jankowska 

Number of co-investigators in the project: 9

Call: SONATA BIS 1 - announced on 2012-03-15

Amount awarded: 1 478 000 PLN

Project start date (Y-m-d): 2013-02-11

Project end date (Y-m-d): 2016-08-10

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Inkubator CO2-O2 NU-4950E Autoflow (50 000 PLN)
  2. Urządzenie do mechanicznej stymulacji komórek (Flexcell FX5000T) (180 000 PLN)
  3. Urządzenie do wykonywania kontrolowanego wysiłku przedramienia (projekt i wykonanie) (25 000 PLN)
  4. Pojemnik do przechowywania linii komórkowych (22 493 PLN)
  5. Urządzenie do automatycznego liczenia komórek (19 959 PLN)
  6. Miernik siły mięśni oddechowych.
  7. dynamometr hydrauliczny (2 szt.) (2 500 PLN)
  8. Zamrażarka niskotemperaturowa (do -80 st.) (60 000 PLN)

Information in the final report

  • Publication in academic press/journals (12)
  • Articles in post-conference publications (14)
  1. Effects of intravenous iron therapy in iron-deficient patients with systolic heart failure: a meta-analysis of randomized controlled trials
    Authors:
    Ewa A. Jankowska, Michał Tkaczyszyn, Tomasz Suchocki, MarcinDrozd,Stephan von Haehling, Wolfram Doehner, Waldemar Banasiak, Gerasimos Filippatos, Stefan D. Anker, and Piotr Ponikowski
    Academic press:
    European Journal of Heart Failure (rok: 2016, tom: 18, strony: 786-795), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1002/ejhf.473 - link to the publication
  2. Vitamin B12 and folate deficiency in chronic heart failure
    Authors:
    Haye H van der Wal, Josep Comin-Colet, Ijsbrand T Klip, Cristina Enjuanes, Niels Grote Beverborg, Adriaan A Voors, Waldemar Banasiak, Dirk J van Veldhuisen, Jordi Bruguera, Piotr Ponikowski, Ewa A Jankowska, Peter van der Meer
    Academic press:
    Heart (rok: 2015, tom: 101, strony: 302-310), Wydawca: BMJ
    Status:
    Published
    DOI:
    10.1136/heartjnl-2014-306022 - link to the publication
  3. Depleted iron stores are associated with inspiratory muscle weakness independently of skeletal muscle mass in men with systolic chronic heart failure
    Authors:
    Tkaczyszyn Michał, Drozd Marcin, Wegrzynowska-Teodorczyk Kinga, Flinta Irena, Kobak Kamil, Banasiak Waldemar, Ponikowski Piotr, Jankowska Ewa A.
    Academic press:
    Journal of Cachexia Sarcopenia and Muscle (rok: 2018, tom: 9 (3), strony: 547-556), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1002/jcsm.12282 - link to the publication
  4. Iron deficiency and red cell indices in patients with heart failure
    Authors:
    Tkaczyszyn Michał, Comín-Colet Joseph, Voors Adriaan A., van Veldhuisen Dirk J, Enjuanes Cristina, Moliner-Borja Pedro, Rozentryt Piotr, Poloński Lech, Banasiak Waldemar, Ponikowski Piotr, van der Meer Peter, Jankowska Ewa A.
    Academic press:
    European Journal of Heart Failure (rok: 2018, tom: 20, strony: 114-122), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1002/ejhf.820 - link to the publication
  5. Both iron excess and iron depletion impair viability of rat H9C2 cardiomyocytes and L6G8C5 myocytes.
    Authors:
    Monika Kasztura, Magdalena Dzięgała, Kamil Kobak, Jacek Bania, Grzegorz Mazur, Waldemar Banasiak, Piotr Ponikowski, Ewa Anita Jankowska
    Academic press:
    Kardiologia Polska (rok: 2017, tom: 75, strony: 267-275), Wydawca: VIA MEDICA
    Status:
    Published
    DOI:
    10.5603/KP.a2016.0155 - link to the publication
  6. Influence of the availability of iron during hypoxia on the genes associated with apoptotic activity and local iron metabolism in rat H9C2 cardiomyocytes and L6G8C5 skeletal myocytes
    Authors:
    Magdalena Dziegala, Monika Kasztura, Kamil Kobak, Jacek Bania, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska
    Academic press:
    Molecular Medicine Reports (rok: 2016, tom: 14 (4), strony: 3969-3977), Wydawca: SPANDIDOS PUBL LTD
    Status:
    Published
    DOI:
    10.3892/mmr.2016.5705 - link to the publication
  7. "ŻELAZNE SERCE" — CO WIEMY, A CZEGO NIE WIEMY?
    Authors:
    Monika Kasztura, Magdalena Stugiewicz, Kamil Kobak, Waldemar Banasiak, Piotr Ponikowski, Ewa A. Jankowska
    Academic press:
    Kosmos, Problemy Nauk Biologicznych (rok: 2014, tom: 63, strony: 387-393), Wydawca: Polskie Towarzystwo Przyrodników im. Kopernika
    Status:
    Published
    DOI:
    brak - link to the publication
  8. Iron deficiency as energetic insult to skeletal muscle inchronic diseases
    Authors:
    Magdalena Dziegala, Krystian Josiak, Monika Kasztura, Kamil Kobak, Stephan von Haehling, Waldemar Banasiak, Stefan D. Anker, Piotr Ponikowski, Ewa Jankowska
    Academic press:
    Journal of Cachexia, Sarcopenia and Muscle (rok: 2018, tom: 9, strony: 802-815), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1002/jcsm.12314 - link to the publication
  9. Iron therapy in patients with heart failure and iron deficiency - review on iron preparations for practitioners.
    Authors:
    Marcin Drozd, Ewa Anita Jankowska, Waldemar Banasiak, Piotr Ponikowski
    Academic press:
    American Journal of Cardiovascular Drugs (rok: 2017, tom: 17, strony: 183-201), Wydawca: ADIS INT LTD
    Status:
    Published
    DOI:
    10.1007/s40256-016-0211-2 - link to the publication
  10. The influence of iron deficiency on the functioning of skeletal muscles: experimental evidence and clinical implications
    Authors:
    Magdalena Stugiewicz, Michał Tkaczyszyn, Monika Kasztura, Waldemar Banasiak, Piotr Ponikowski, and Ewa A. Jankowska
    Academic press:
    European Journal of Heart Failure (rok: 2016, tom: 18, strony: 762-773), Wydawca: WILEY-BLACKWELL
    Status:
    Published
    DOI:
    10.1002/ejhf.467 - link to the publication
  11. Iron deficiency in heart failure: Impact on response to cardiac resynchronization therapy
    Authors:
    Joanna Bojarczuk, Krystian Josiak, Monika Kasztura, Dorota Kustrzycka-Kratochwil, Krzysztof Nowak, Dariusz Jagielski, Waldemar Banasiak, Ewa Anita Jankowska, Piotr Ponikowski
    Academic press:
    INTERNATIONAL JOURNAL OF CARDIOLOGY (rok: 2016, tom: 222, strony: 133-134), Wydawca: ELSEVIER IRELAND LTD
    Status:
    Published
    DOI:
    10.1016/j.ijcard.2016.07.280 - link to the publication
  12. Iron limitation promotes the atrophy of skeletal myocytes, whereas iron supplementation prevents this process in the hypoxic conditions
    Authors:
    Kamil Kobak, Monika Kasztura, Magdalena Dziegala, Jacek Bania, Violetta Kapuśniak, Waldemar Banasiak, Piotr Ponikowski, and Ewa A. Jankowska
    Academic press:
    INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (rok: 2018, tom: 41, strony: 2678-2686), Wydawca: SPANDIDOS PUBL LTD
    Status:
    Published
    DOI:
    10.3892/ijmm.2018.3481 - link to the publication
  1. Iron deficiency predicts decreased exercise capacity and physical fitness independently of skeletal muscle mass in men with heart failure with reduced ejection fraction
    Authors:
    M Tkaczyszyn, M Drozd, K Wegrzynowska-Teodorczyk , A Czarniawska, R Krajewski, TH Menghis , R Rydzyk, U Szydelko, P Wojcik, W Banasiak, P Ponikowski, EA Jankowska
    Conference:
    Heart Failure 2017 - 4th World Congress on Acute Heart Failure, Paris, France (rok: 2017, ), Wydawca: European Journal of Heart Failure ( 2017 ) 19 ( Suppl. S1 )
    Data:
    konferencja 29 April - 02 May 2017
    Status:
    Published
  2. Influence of iron availability in the normoxic versus hypoxic conditions on the morphology and atrophy of skeletal myocytes.
    Authors:
    K A Kobak, M Kasztura, M Dziegala, J Bania, A Orlowska, V Kapusniak, L Kiczak, K Josiak, W Banasiak, P Ponikowski, E A Jankowska
    Conference:
    Heart Failure 2017 - 4th World Congress on Acute Heart Failure, Paris, France (rok: 2017, ), Wydawca: European Journal of Heart Failure ( 2017 ) 19 ( Suppl. S1 )
    Data:
    konferencja 29 April - 02 May 2017
    Status:
    Published
  3. Different clinical profile of patients with heart failure with reduced ejection fraction with low hepcidin versus high soluble transferrin receptor
    Authors:
    M Kasztura, M Drozd, P Rozentryt, L Polonski, J Malyszko, E KocZorawska, J Majda, W Banasiak, P Ponikowski, EA Jankowska
    Conference:
    Heart Failure 2016 Conference, Florence (Italy) (rok: 2016, ), Wydawca: European Journal of Heart Failure Abstracts Supplement ( 2016 ) 18 ( Supplement 1 )
    Data:
    konferencja 21-24.05.2016
    Status:
    Published
  4. Impaired functioning and low mass of skeletal muscles in men with heart failure with reduced ejection fraction are reflected by reduced musclederived irisin
    Authors:
    M. Kasztura, M. Dziegala, K.A. Kobak, M. Tkaczyszyn, M. Drozd, K. WegrzynowskaTeodorczyk, K. Josiak, J. Bania, L. Kiczak, W. Banasiak, P. Ponikowski, E.A. Jankowska
    Conference:
    ESC Congress 2018, Monachium (Niemcy) (rok: 2018, ), Wydawca: European Heart Journal ( 2018 ) 39 ( Supplement )
    Data:
    konferencja 25-29.08.2018
    Status:
    Published
  5. Low ferritin reflecting depleted iron stores predicts inspiratory muscle weakness independently of skeletal muscle mass in men with heart failure with reduced ejection fraction
    Authors:
    M. Tkaczyszyn, M. Drozd, K. Wegrzynowska-Teodorczyk, I. Flinta, M. Bolanowski, D. Jedrzejuk, W. Banasiak, P. Ponikowski, EA. Jankowska
    Conference:
    Heart Failure 2017 - 4th World Congress on Acute Heart Failure, Paris, France (rok: 2017, ), Wydawca: European Journal of Heart Failure ( 2017 ) 19 ( Suppl. S1 )
    Data:
    konferencja 29 April - 02 May 2017
    Status:
    Published
  6. Musclederived follistatin and decorin levels in men with heart failure with reduced ejection fraction and different iron status
    Authors:
    M.M. Dziegala, M. Kasztura, K. Kobak, M. Tkaczyszyn, M. Drozd, K. WegrzynowskaTeodorczyk, K. Josiak, J. Bania, L. Kiczak, W. Banasiak, P. Ponikowski, E.A. Jankowska
    Conference:
    ESC Congress 2018, Monachium (Niemcy) (rok: 2018, ), Wydawca: European Heart Journal (2018) 39 ( Supplement)
    Data:
    konferencja 25-29.08.2018
    Status:
    Published
  7. Iron deficiency predicts skeletal musclederived hemojuvelin in men with heart failure with reduced ejection fraction
    Authors:
    M Tkaczyszyn, M Drozd, K WegrzynowskaTeodorczyk, I Flinta, M Kasztura, M Dziegala, K Kobak, W Banasiak, P Ponikowski, EA Jankowska
    Conference:
    Heart Failure 2018 & World Congress on Acute Heart Failure, Wiedeń (Austria) (rok: 2018, ), Wydawca: European Journal of Heart Failure (2018) 20 ( Suppl. S1)
    Data:
    konferencja 26 - 29 maja 2018
    Status:
    Published
  8. Iron status and musclederived secretion of regenerative and prohypertrophic myokines (follistatin and decorin) in men with heart failure with reduced ejection fraction
    Authors:
    MM Dziegala, M Kasztura, KA Kobak, M Tkaczyszyn, M Drozd, K WegrzynowskaTeodorczyk, K Josiak, J Bania , L Kiczak , W Banasiak , P Ponikowski , EA Jankowska
    Conference:
    Heart Failure 2018 & World Congress on Acute Heart Failure, Wiedeń (Austria) (rok: 2018, ), Wydawca: European Journal of Heart Failure ( 2018 ) 20 ( Suppl. S1 )
    Data:
    konferencja 26 - 29 maja 2018
    Status:
    Published
  9. Patients with heart failure with reduced ejection fraction with low hepcidin versus high soluble transferrin receptor demonstrate different clinical profile.
    Authors:
    M. Kasztura, M. Drozd, P. Rozentryt, L. Polonski, J. Malyszko, E. Koc-Zorawska, J. Majda, W. Banasiak, P. Ponikowski, E.A. Jankowska
    Conference:
    ESC Congress 2016, Rome (Italy) (rok: 2016, ), Wydawca: European Heart Journal ( 2016 ) 37 ( Abstract Supplement )
    Data:
    konferencja 27-31.08.2016
    Status:
    Published
  10. Reduced musclederived irisin reflects low muscles mass and impaired functioning of skeletal muscles in men with heart failure with reduced ejection fraction
    Authors:
    M Kasztura, M Dziegala, KA Kobak, M Tkaczyszyn, M Drozd, K WegrzynowskaTeodorczyk, K Josiak, J Bania, L Kiczak, W Banasiak6 P Ponikowski, EA Jankowska
    Conference:
    Heart Failure 2018 & World Congress on Acute Heart Failure, Wiedeń (Austria) (rok: 2018, ), Wydawca: European Journal of Heart Failure ( 2018 ) 20 ( Suppl. S1 )
    Data:
    konferencja 26 - 29 maja 2018
    Status:
    Published
  11. Iron deficiency predicts respiratory muscle weakness in men with heart failure with reduced ejection fraction
    Authors:
    M. Tkaczyszyn, M. Drozd, K. WegrzynowskaTeodorczyk, I. Flinta, W. Banasiak, P. Ponikowsk , E.A. Jankowska
    Conference:
    Heart Failure 2016 Conference, Florence (Italy) (rok: 2016, ), Wydawca: European Journal of Heart Failure Abstracts Supplement ( 2016 ) 18 ( Supplement 1 )
    Data:
    konferencja 21-24.05.2016
    Status:
    Published
    DOI:
    link to the publication
  12. Iron status, respiratory muscle strength, and physical fitness in men with heart failure with reduced ejection fraction
    Authors:
    Tkaczyszyn Michał, Drozd Marcin, Wegrzynowska-Teodorczyk Kinga, Flinta Irena, Bolanowski Marek, Jędrzejuk D., Banasiak Waldemar, Ponikowski Piotr, Jankowska Ewa A.
    Conference:
    ESC Congress 2017, Barcelona, Spain (rok: 2017, ), Wydawca: European Heart Journal ( 2017 ) 38 ( Supplement )
    Data:
    konferencja 26-30.08.2017
    Status:
    Published
  13. Iron availability and the expression of genes of oxidative and nonoxidative metabolic pathways in primary human cardiac myocytes cultured upon mechanical stretch
    Authors:
    MM Dziegala, M Kasztura, K A Kobak, J Bania, L Kiczak, K Josiak, W Banasiak, P Ponikowski, E A Jankowska
    Conference:
    Heart Failure 2017 - 4th World Congress on Acute Heart Failure, Paris, France (rok: 2017, ), Wydawca: European Journal of Heart Failure ( 2017 ) 19 ( Suppl. S1 )
    Data:
    konferencja 29 April - 02 May 2017
    Status:
    Published
  14. Low circulating hepcidin as a measure of iron deficiency in patients with acute and stable heart failure
    Authors:
    M Kasztura, M Drozd, P Rozentryt, L Polonski, J Malyszko, E Koc-Zorawska, K Josiak, M Sokolski, J Biegus, R Zymlinski, W Banasiak, P Ponikowski, E A Jankowska
    Conference:
    Heart Failure 2017 - 4th World Congress on Acute Heart Failure, Paris, France (rok: 2017, ), Wydawca: European Journal of Heart Failure ( 2017 ) 19 ( Suppl. S1 )
    Data:
    konferencja 29 April - 02 May 2017
    Status:
    Published

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