Projects funded by the NCN


Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Antiatherogenic properties of the third generation beta-adrenolytics, on the improved experimental model of atherosclerosis: eNOS & apoE - double knockout mice

2012/05/B/NZ4/02743

Keywords:

atherosclerosis eNOS & apoE-double knockout mice nebivolol carvedilol

Descriptors:

  • NZ4_12: Other related subjects

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Lekarski

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Jacek Jawień 

Number of co-investigators in the project: 3

Call: OPUS 3 - announced on 2012-03-15

Amount awarded: 370 926 PLN

Project start date (Y-m-d): 2013-02-15

Project end date (Y-m-d): 2015-06-14

Project duration:: 28 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (4)
  1. Comparison between Sexes during the Development of Atherosclerosis in apoE & eNOS: Double Knockout Mice.
    Authors:
    Wiśniewska A, Kuś K, Totoń-Żurańska J, Jawień J, Olszanecki R, Korbut R.
    Academic press:
    Journal of Pharmacological Reports (rok: 2016, tom: 1, strony: 121-126), Wydawca: OMICS International
    Status:
    Published
  2. Effect of nebivolol treatment on atherosclerotic plaque components in apoE-knockout mice.
    Authors:
    Pyka-Fościak G, Jawień J, Gajda M, Jasek E, Litwin JA.
    Academic press:
    J Physiol Pharmacol (rok: 2013, tom: 64, strony: 745-750), Wydawca: Polish Physiological Society
    Status:
    Published
  3. Significant deterioration of anti-atherogenic efficacy of nebivolol in a double (apoE & eNOS) knockout mouse model of atherosclerosis in comparison to single (apoE) knockout model.
    Authors:
    Kuś K, Wiśniewska A, Totoń-Żurańska J, Olszanecki R, Jawień J, Korbut R.
    Academic press:
    J Physiol Pharmacol (rok: 2014, tom: 65, strony: 877-881), Wydawca: Polish Physiological Society
    Status:
    Published
  4. Quantitative proteomics reveals decreased expression of major urinary proteins (MUPs) in the liver of apoE/eNOS-DKO mice.
    Authors:
    Stachowicz A, Olszanecki R, Suski M, Wiśniewska A, Kuś K, Białas M, Jawień J, Korbut R.
    Academic press:
    Clin Exp Pharmacol Physiol , Wydawca: Australian Physiological Society
    Status:
    Accepted for publication
    DOI:
    10.1111/1440-1681.12927. - link to the publication