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Information on the principal investigator and host institution

Information of the project and the call

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Functional analysis of stearoyl-CoA desaturase as a potent regulator of metabolic homeostasis and fatty acid-derived autophagy of pancreatic beta cells

2011/03/B/NZ4/03055

Keywords:

pancreatic islets insulin diabetes autophagy lipids

Descriptors:

  • NZ4_2: Physiology
  • NZ4_11: Metabolism
  • NZ4_6: Endocrinology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Instytut Biologii Doświadczalnej im. M. Nenckiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Agnieszka Dobrzyń 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 444 000 PLN

Project start date (Y-m-d): 2012-09-11

Project end date (Y-m-d): 2015-09-10

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Information in the final report

  • Publication in academic press/journals (3)
  • Articles in post-conference publications (5)
  1. CB1 cannabinoid receptors couple to focal adhesion kinase to control insulin release
    Authors:
    Malenczyk K, Jazurek M, Keimpema E, Silvestri C, Janikiewicz J, Mackie K, Di Marzo V, Redowicz MJ, Harkany T, Dobrzyn A.
    Academic press:
    Journal of Biological Chemistry (rok: 2013, tom: 288, strony: 32685-32699), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1074/jbc.M113.478354 - link to the publication
  2. Inhibition of SCD1 impairs palmitate-derived autophagy at the step of autophagosome-lysosome fusion in pancreatic β-cells
    Authors:
    Janikiewicz J, Hanzelka K, Dziewulska A, Kozinski K, Dobrzyn P, Bernas T, Dobrzyn A
    Academic press:
    Journal of Lipid Research (rok: 2015, tom: 56, strony: 1901-1911), Wydawca: American Society for Biochemistry and Molecular Biology
    Status:
    Published
    DOI:
    10.1194/jlr.M059980 - link to the publication
  3. Islet beta-cell failure in type 2 diabetes - Within the network of toxic lipids
    Authors:
    Janikiewicz J, Hanzelka K, Kozinski K, Kolczynska K, Dobrzyn A
    Academic press:
    Biochemical and Biophysical Research Communications (rok: 2015, tom: 460, strony: 491-496), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.bbrc.2015.03.153 - link to the publication
  1. The impairment of palmitate-derived autophagy depends on stearoyl-CoA desaturase 1 enzymatic activity
    Authors:
    Justyna Janikiewicz, Anna Dziewulska, Katarzyna Hanzelka, Kamil Koziński, Katarzyna Kolczyńska, Agnieszka Dobrzyń
    Conference:
    BIO2014 (rok: 2014, ), Wydawca: Polskie Towarzystwo Biochemiczne
    Data:
    konferencja 9-12 wrzesień
    Status:
    Published
    DOI:
    link to the publication
  2. The role of adipose-derived Wnts in beta cell adaptation during progression of type 2 diabetes
    Authors:
    Kamil Koziński, Justyna Janikiewicz, Magdalena Jazurek, Katarzyna Kolczyńska, Agnieszka Dobrzyń
    Conference:
    54th International Conference on the Bioscience of Lipids (rok: 2013, ), Wydawca: International Conference on the Bioscience of Lipids
    Data:
    konferencja 17-21 wrzesień
    Status:
    Published
  3. CB1 cannabinoid receptor activation leads to focal adhesion kinase-dependent cytoskeletal remodeling in pancreatic beta-cells and induces insulin release
    Authors:
    Katarzyna Maleńczyk, Magdalena Jazurek, Erik Keimpema, Justyna Jankiewicz, Jolanta M. Rędowicz, Tibor Harkany, Agnieszka Dobrzyń
    Conference:
    54th International Conference on the Bioscience of Lipids (rok: 2013, ), Wydawca: International Conference on the Bioscience of Lipids
    Data:
    konferencja 17-21 wrzesień
    Status:
    Published
  4. Stearoyl-CoA desaturase 1 affects outcome of palmitate-derived autophagy in pancreatic β cells
    Authors:
    Justyna Janikiewicz, Kamil Koziński, Magdalena Jazurek, Agnieszka Dobrzyń
    Conference:
    54th International Conference on the Bioscience of Lipids (rok: 2013, ), Wydawca: International Conference on the Bioscience of Lipids
    Data:
    konferencja 17-21 wrzesień
    Status:
    Published
  5. Wnt signaling increases rate of fatty acid oxidation in pancreatic beta-cells through specific activation of PPARalpha pathway
    Authors:
    Kamil Koziński, Agnieszka Dobrzyń, Justyna Janikiewicz
    Conference:
    The 11th Biennial International Society for the Study of Fatty Acids and Lipids Congress (rok: 2014, ), Wydawca: International Society for the Study of Fatty Acids and Lipids
    Data:
    konferencja 28 czerwiec-2 lipiec
    Status:
    Published
    DOI:
    link to the publication

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