Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

An attempt to elucidate the role of clusterin and lipid rafts in Alzheimer's disease etiology.

2011/03/B/NZ7/02328

Keywords:

clusterin cholesterol secretases amyloid precursor protein beta amyloid PC12 cells kinases transcription factors

Descriptors:

  • NZ7_12: Prevention of human diseases

Panel:

NZ7 - Diagnostic tools, therapies and public health: public health, epidemiology, environmental health risks and occupational medicine, medical ethics, drug discovery and therapies, pharmacology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Arkadiusz Orzechowski 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 690 722 PLN

Project start date (Y-m-d): 2012-09-03

Project end date (Y-m-d): 2016-03-02

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Czytnik wielopłytek model INFINITE M1000 firmy TECAN (338 942 PLN)
  2. Mikrowirówka (minispin) firmy ROTH.

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (2)
  1. Killing Me Softly: Connotations to Unfolded Protein Response and Oxidative Stress in Alzheimer's Disease
    Authors:
    Beata Pająk, Elzbieta Kania, Arkadiusz Orzechowski
    Academic press:
    Oxidative Medicine and Cellular Longevity (rok: 2016, tom: 2016, strony: 17), Wydawca: Hindavi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2016/1805304 - link to the publication
  2. Nucleofection of Rat Pheochromocytoma PC-12 Cells with Human Mutated Beta-Amyloid Precursor Protein Gene (APP-sw) Leads to Reduced Viability, Autophagy-Like Process, and Increased Expression and Secretion of Beta Amyloid
    Authors:
    Beata Pająk, Elżbieta Kania, Arkadiusz Orzechowski
    Academic press:
    Biomed Research International (Journal of Biomedicine and Biotechnology) (rok: 2014, tom: 2015, strony: 10), Wydawca: Hindawi Publishing Corporation
    Status:
    Published
    DOI:
    10.1155/2015/746092 - link to the publication
  1. Mutated human beta-amyloid prekursor protein gene (APP-sw) causes aberrant autophagy in NGF-differentiated neural PC-12 rat pheochromocytoma cells.
    Authors:
    Pająk B, Kania E, Orzechowski A.
    Conference:
    The 12th International Symposium Molecular basis of pathology and therapy in neurological disorders", Warsaw, Poland (rok: 2014, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 20-21.10.2014
    Status:
    Published
  2. Functional analysis of nucleofected PC-12 rat pheochromocytoma cells as cellular models for familial and sporadic form of Alzheimer's disease.
    Authors:
    Pająk B, Kania E, Orzechowski A.
    Conference:
    26th Congress of the Polish Physiological Society, Szczecin, Poland (rok: 2014, ), Wydawca: J. Physiol. Pharmacol. 65 (Suppl. 1)
    Data:
    konferencja 18-20.09.2014
    Status:
    Published

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy