Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

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Epicutaneous (EC) application of a protein antigen as a new method to treat collagen induced arthritis (CIA) in humanized HLA-DR4-Tg mice. Clinical implications.

2011/03/B/NZ6/00801

Keywords:

skin-induced tolerance collagen induced arthritis T regulatory cells humanized HLA-DR4-Tg mice

Descriptors:

  • NZ6_1: Adaptive and innate immunity
  • NZ6_3: Animal immunology

Panel:

NZ6 - Human and animal immunology and infection: immunity, immune disorders, immunotherapy, infectious and invasive diseases, microbiology, transplantology, allergology

Host institution :

Uniwersytet Jagielloński - Collegium Medicum, Collegium Medicum, Wydział Nauk o Zdrowiu

woj. małopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Marian Szczepanik 

Number of co-investigators in the project: 5

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 553 300 PLN

Project start date (Y-m-d): 2012-08-22

Project end date (Y-m-d): 2016-02-21

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. aparat do przeprowadzenia reakcji Real Time - PCR.
  2. system dokumentacji żeli (20 000 PLN)
  3. kuchenka mikrofalowa (300 PLN)
  4. spektrofotometr do pomiaru stężenia DNA, RNA i białka (40 000 PLN)
  5. aparat do elektroforezy (3 700 PLN)
  6. termocykler (30 000 PLN)
  7. wirówka ependorf z chłodzeniem (16 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (1)
  1. Epicutaneous (EC) immunization with type II collagen (COLL II) induces CD4(+) CD8(+) T suppressor cells that protect from collagen-induced arthritis (CIA).
    Authors:
    Katarzyna Marcińska, Monika Majewska-Szczepanik, Agata Lazar, Paulina Kowalczyk, Dominka Biała, Dorota Woźniak, Marian Szczepanik
    Academic press:
    Pharamcological Reports (rok: 2016, tom: 68, strony: 483-489), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2015.11.004. - link to the publication
  2. Epicutaneous Immunization with Collagen Induces TCRαβ Suppressor T Cells That Inhibit Collagen-Induced Arthritis.
    Authors:
    Katarzyna Marcińska, Monika Majewska-Szczepanik, Katarzyna Z. Maresz, Marian Szczepanik
    Academic press:
    International Archives of Allergy and Immunology (rok: 2015, tom: 166, strony: 121-134), Wydawca: Karger
    Status:
    Published
    DOI:
    10.1159/000375404 - link to the publication
  3. Skin-induced tolerance as a new needle free therapeutic strategy.
    Authors:
    Marian Szczepanik
    Academic press:
    Pharmacological Reports (rok: 2014, tom: 66, strony: 192-197), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.pharep.2013.09.001 - link to the publication
  4. Tc1-mediated contact sensitivity reaction, its mechanism and regulation
    Authors:
    Magdalena Zemelka-Wiącek, Marian Szczepanik
    Academic press:
    Postępy Higieny Medycyny Doświadczalnej (rok: 2014, tom: 68, strony: 955-969), Wydawca: Index Copernicus International
    Status:
    Published
    DOI:
    - - link to the publication
  1. Skin-induced suppression of contact sensitivity (CS) in humanized HLA-DR4 transgenic mice
    Authors:
    Monika Majewska-Szczepanik, Iwona Dorożyńska, Katarzyna Marcińska, Marian Szczepanik
    Conference:
    XV Zjazd Polskiego Towarzystwa Immunologii Doświadczalnej i Klinicznej (rok: 2014, ), Wydawca: Termedia
    Data:
    konferencja 26.06.2014-28.06.2014
    Status:
    Published

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