Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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New methods for the determination of RNA secondary structure, tools towards studies biological activities of RNAs

2011/03/B/NZ1/00576

Keywords:

secondary and tertiary RNA structure RNA mapping methods RNA chemistry RNA influenza virus

Descriptors:

  • NZ1_4:
  • NZ1_6:
  • NZ1_1:

Panel:

NZ1 - Molecular biology, structural biology, biotechnology: molecular biology, structural biology, biotechnology

Host institution :

Instytut Chemii Bioorganicznej Polskiej Akademii Nauk

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

prof. Ryszard Kierzek 

Number of co-investigators in the project: 7

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 708 360 PLN

Project start date (Y-m-d): 2012-08-02

Project end date (Y-m-d): 2015-08-01

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Wytrząsarka inkubowana (60 000 PLN)
  2. Pompa olejowa wysokiej próżni (9 000 PLN)
  3. Kaseta z ekranem do fosforimigera (15 000 PLN)
  4. Zestaw komputerowy (komputer i monitor) (7 000 PLN)
  5. Termomikser z blokiem wymiennym (14 000 PLN)
  6. Zasilacz do elektroforezy wysokonapięciowej. (9 000 PLN)

Information in the final report

  • Publication in academic press/journals (17)
  1. Microarrays for identifying binding sites and probing structure of RNAs
    Authors:
    R. Kierzek, DH. Turner, E. Kierzek
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 45669), Wydawca: Oxford Univ. Press
    Status:
    Published
    DOI:
    10.1093/nar/gku1303 - link to the publication
  2. The contribution of pseudouridine to stabilities and structure of RNAs.
    Authors:
    E. Kierzek, M.Malgowska, J. Lisowiec, D.H. Turner, Z. Gdaniec and R. Kierzek
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 3492-3501), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gkt1330 - link to the publication
  3. Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides
    Authors:
    Y. Zhou, E. Kierzek, Z.P. Loo, M. Antonio, Y.H. Yau, Y.W. Chuah, S. Geifman-Shochat, R. Kierzek and G. Chen
    Academic press:
    Nucleic Acids Research (rok: 2013, tom: 41, strony: 6664-6673), Wydawca: Oxford University Press
    Status:
    Published
  4. Metal-promoted synthesis, characterization, crystal structure and RNA cleavage ability of 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone) lanthanide complexes
    Authors:
    M. Kozlowski, R. Kierzek, M. Kubicki and W. Radecka-Paryzek
    Academic press:
    J. Inorgan. Biochem. (rok: 2013, tom: 126, strony: 38-45), Wydawca: Elsevier
    Status:
    Published
    DOI:
    brak - link to the publication
  5. Interplay of LNA and 2ʹ-O-Methyl RNA in the Structure and Thermodynamics of RNA Hybrid Systems: A Molecular Dynamics Study using the Revised AMBER Force Field and Comparison with Experimental Results
    Authors:
    I. Yildirim, E. Kierzek, R. Kierzek, G. Schatz
    Academic press:
    Journal Physical Chemistry B (rok: 2014, tom: 118, strony: 14177-14187), Wydawca: ACS Publications
    Status:
    Published
    DOI:
    10.1021/jp506703g - link to the publication
  6. Novel Conformation of an RNA structural switch
    Authors:
    S.D. Kennedy, R. Kierzek, D.H. Turner
    Academic press:
    Biochemistry (rok: 2012, tom: 51, strony: 9257-9259), Wydawca: ACS
    Status:
    Published
  7. Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats.
    Authors:
    M. Malgowska, D. Gudanis, R. Kierzek, E. Wyszko, V. Gabelica, Z. Gdaniec
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 10196-10207), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku710 - link to the publication
  8. Structural determinants for alternative splicing regulation of the MAPT pre-mRNA
    Authors:
    J. Lisowiec, D. Magner, E. Kierzek, E. Lenartowicz, R. Kierzek
    Academic press:
    RNA Biology (rok: 2015, tom: 12, strony: 330-342), Wydawca: TAYLOR & FRANCIS INC
    Status:
    Published
    DOI:
    10.1080/15476286.2015.1017214 - link to the publication
  9. Secondary Structure of a Conserved Domain in the Intron of Influenza A NS1 mRNA
    Authors:
    S.F. Priore, E. Kierzek, R. Kierzek, J.R. Baman; W.N. Moss; L.I. Dela-Moss, D.H. Turner
    Academic press:
    PLOS ONE (rok: 2013, tom: 8, strony: e70615), Wydawca: plos org
    Status:
    Published
  10. Novel Conformation of an RNA structural switch
    Authors:
    S.D. Kennedy, R. Kierzek, D.H. Turner
    Academic press:
    Biochemistry (rok: 2012, tom: 51, strony: 9257-9259), Wydawca: ACS
    Status:
    Published
    DOI:
    brak - link to the publication
  11. Ultrahigh-resolution crystal structures of Z-DNA in complex with Mn2+ and Zn2+ ions
    Authors:
    P. Drozdzal, M. Gilski, R. Kierzek, L. Lomozik and M. Jaskolski
    Academic press:
    Acta Crystallographica, section D (rok: 2013, tom: 69, strony: 1180-1190), Wydawca: IUCr
    Status:
    Published
    DOI:
    brak - link to the publication
  12. Recognition of RNA duplexes by chemically modified triplex-forming oligonucleotides
    Authors:
    Y. Zhou, E. Kierzek, Z.P. Loo, M. Antonio, Y.H. Yau, Y.W. Chuah, S. Geifman-Shochat, R. Kierzek and G. Chen
    Academic press:
    Nucleic Acids Research (rok: 2013, tom: 41, strony: 6664-6673), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    brak - link to the publication
  13. Microarrays for identifying binding sites and probing structure of RNAs
    Authors:
    R. Kierzek, DH. Turner, E. Kierzek
    Academic press:
    Nucleic Acids Research (rok: 2015, tom: 43, strony: 45669), Wydawca: Oxford Univ. Press
    Status:
    Published
    DOI:
    10.1093/nar/gku1303 - link to the publication
  14. Distinctive structural motifs of RNA G-quadruplexes composed of AGG, CGG and UGG trinucleotide repeats.
    Authors:
    M. Malgowska, D. Gudanis, R. Kierzek, E. Wyszko, V. Gabelica, Z. Gdaniec
    Academic press:
    Nucleic Acids Research (rok: 2014, tom: 42, strony: 10196-10207), Wydawca: Oxford University Press
    Status:
    Published
    DOI:
    10.1093/nar/gku710 - link to the publication
  15. High-resolution crystal structure of Z-DNA in complex with Cr3+ cations
    Authors:
    P. Drozdzal, M. Gilski, R. Kierzek, L. Lomozik, M. Jaskolski
    Academic press:
    Journal of Biological Inorganic Chemistry (rok: 2015, tom: 20, strony: 595-602), Wydawca: Springer
    Status:
    Published
    DOI:
    10.1007/s00775-015-1247-5 - link to the publication
  16. Ultrahigh-resolution crystal structures of Z-DNA in complex with Mn2+ and Zn2+ ions
    Authors:
    P. Drozdzal, M. Gilski, R. Kierzek, L. Lomozik and M. Jaskolski
    Academic press:
    Acta Crystallographica, section D (rok: 2013, tom: 69, strony: 1180-1190), Wydawca: IUCr
    Status:
    Published
  17. Metal-promoted synthesis, characterization, crystal structure and RNA cleavage ability of 2,6-diacetylpyridine bis(2-aminobenzoylhydrazone) lanthanide complexes
    Authors:
    M. Kozlowski, R. Kierzek, M. Kubicki and W. Radecka-Paryzek
    Academic press:
    J. Inorgan. Biochem. (rok: 2013, tom: 126, strony: 38-45), Wydawca: Elsevier
    Status:
    Published

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