Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

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The role of CDK5 in inflammatory reaction in experimental model of Alzheimer's disease

2011/03/B/NZ3/04549

Keywords:

CDK5 Alzheimer's disease inflammation roscovitin

Descriptors:

  • NZ3_5: Molecular neurobiology
  • NZ3_6: Cell neurobiology
  • NZ3_4: Ageing

Panel:

NZ3 - Cellular and developmental biology: cell biology, developmental biology, ageing biology, neurobiology

Host institution :

Instytut Medycyny Doświadczalnej i Klinicznej im. Mirosława Mossakowskiego PAN

woj. mazowieckie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr hab. Grzegorz Czapski 

Number of co-investigators in the project: 8

Call: OPUS 2 - announced on 2011-09-15

Amount awarded: 390 252 PLN

Project start date (Y-m-d): 2012-08-16

Project end date (Y-m-d): 2016-02-15

Project duration:: 42 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. komputer osobisty z oprogramowaniem biurowym i naukowym (Office, Endnote, GraphPad Prism) (8 000 PLN)

Information in the final report

  • Publication in academic press/journals (2)
  • Articles in post-conference publications (8)
  • Book publications / chapters in book publications (1)
  1. Cdk5 at crossroads of protein oligomerization in neurodegenerative diseases: facts and hypotheses.
    Authors:
    Wilkaniec A, Czapski GA, Adamczyk A.
    Academic press:
    Journal of Neurochemistry (rok: 2016, tom: 136, strony: 222-233), Wydawca: WILEY
    Status:
    Published
    DOI:
    10.1111/jnc.13365 - link to the publication
  2. The mechanisms regulating cyclin-dependent kinase 5 in hippocampus during systemic inflammatory response: The effect on inflammatory gene expression.
    Authors:
    Czapski GA, Gąssowska M, Wilkaniec A, Chalimoniuk M, Strosznajder JB, Adamczyk A.
    Academic press:
    Neurochemistry International (rok: 2016, tom: 93, strony: 103-112), Wydawca: ELSEVIER
    Status:
    Published
    DOI:
    10.1016/j.neuint.2016.01.005 - link to the publication
  1. Molecular and ultrastructural alterations in the brain after peripheral stimulation of innate immune system. The role of PARP and CDK5 in regulation of gene expression
    Authors:
    Czapski GA, Strosznajder RP, Adamczyk A, Gajkowska B, Strosznajder JB
    Conference:
    Neurochemical Conference 2013 The Days of Neurochemistry Emerging topics in neurological diseases: molecular mechanisms, diagnosis and therapy" (rok: 2013, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 24-25 października 2013 r.
    Status:
    Published
    DOI:
    link to the publication
  2. The role of cyclin dependent kinase 5 in regulation of inflammatory signalling in the brain. Relevance to Alzheimer's disease pathogenesis.
    Authors:
    Anna Wilkaniec, Agata Adamczyk, Grzegorz A. Czapski
    Conference:
    2014 Annual ASN Meeting (rok: 2014, ), Wydawca: Transactions of the American Society for Neurochemistry
    Data:
    konferencja 8-12 marca
    Status:
    Published
  3. AMYLOID-β AT THE CROSSROAD OF NEURODEGENERATION AND NEUROINFLAMMATION
    Authors:
    Grzegorz A. Czapski
    Conference:
    12th International Congress of the Polish Neuroscience Society (rok: 2015, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 6-8 września 2015 r.
    Status:
    Published
    DOI:
    link to the publication
  4. Cyclin dependent kinase 5 and its modulatory role in transcription of inflammation-related genes in the brain.
    Authors:
    Grzegorz A. Czapski, Anna Wilkaniec, Magdalena Gąssowska, Joanna B. Strosznajder, Agata Adamczyk
    Conference:
    12th International Symposium Molecular basis of pathology and therapy in neurological disorders" (rok: 2014, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 20-21 listopada
    Status:
    Published
    DOI:
    link to the publication
  5. Cyclin-dependent kinase 5 signaling in neuroinflammation and neurodegeneration
    Authors:
    Grzegorz A. Czapski
    Conference:
    The Neurochemical Conference 2015; The Days of Neurochemistry; Neuropsychoimmunological mechanisms in the pathology of neurodegenerative diseases: From biomarkers to therapeutics" (rok: 2015, ), Wydawca: Folia Neuropathologica
    Data:
    konferencja 22-23 października 2015 r.
    Status:
    Published
    DOI:
    link to the publication
  6. PHARMACOLOGICAL INHIBITION OF CYCLINDEPENDENT KINASE 5 MODIFIES GENE EXPRESSION IN MOUSE MODEL OF AMYLOID BETA TOXICITY
    Authors:
    Grzegorz A. Czapski, Anna Wilkaniec, Magdalena Gąssowska, Agata Adamczyk
    Conference:
    12th International Congress of the Polish Neuroscience Society (rok: 2015, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 6-8 września 2015 r.
    Status:
    Published
    DOI:
    link to the publication
  7. The role ofCdk5/p35 and cPLA2/LOX in neuroinflammation and neurodegeneration
    Authors:
    Czapski GA, Cąkała M, Strosznajder JB
    Conference:
    11th International Congress of the Polish Neuroscience Society (rok: 2013, ), Wydawca: Acta Neurobiologiae Experimentalis
    Data:
    konferencja 15-17 września 2013 r.
    Status:
    Published
    DOI:
    link to the publication
  8. Inhibition of Cyclin-dependent kinase 5 attenuates NF-B –regulated gene expression in the brain during lipopolysaccharide-evoked systemic inflammation.
    Authors:
    Grzegorz A. Czapski, Małgorzata Chalimoniuk, Joanna B. Strosznajder, Agata Adamczyk.
    Conference:
    1st Congress of the Polish Biochemistry, Cell Biology and Bioinformatics (rok: 2014, ), Wydawca: Acta Biochimica Polonica
    Data:
    konferencja 9-12 września
    Status:
    Published
    DOI:
    link to the publication
  1. Systemic inflammatory reaction and pathophysiological alteration in the brain
    Authors:
    Czapski GA, Strosznajder JB
    Book:
    Neuro-Immune Interactions in the Adult Central Nervous System (rok: 2014, tom: -, strony: 23-53), Wydawca: Nova Science Publishers, Inc.
    Status:
    Published

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