Projects funded by the NCN

Information on the principal investigator and host institution

Information of the project and the call

Keywords

Equipment

Delete all

The role of orexin receptor 1 and 2 (OXR1, OXR2) in the regulation of pancreatic beta and alpha cells functions

2011/03/N/NZ4/02965

Keywords:

orexin pancreas orexin receptors beta cells alpha cells type 2 diabetes

Descriptors:

  • NZ4_2: Physiology
  • NZ4_11: Metabolism
  • NZ4_6: Endocrinology

Panel:

NZ4 - Biology of tissues, organs and organisms: morphology and functions of animal's and human's systems, organs and organisms, experimental medicine, basics of neurology

Host institution :

Uniwersytet Przyrodniczy w Poznaniu, Wydział Hodowli i Biologii Zwierząt

woj. wielkopolskie

Other projects carried out by the institution 

Principal investigator (from the host institution):

dr Marek Skrzypski 

Number of co-investigators in the project: 2

Call: PRELUDIUM 2 - announced on 2011-09-15

Amount awarded: 269 850 PLN

Project start date (Y-m-d): 2012-11-19

Project end date (Y-m-d): 2015-11-18

Project duration:: 36 months (the same as in the proposal)

Project status: Project settled

Equipment purchased [PL]

  1. Płatkarka lodu SCOTSMAN AF 80 AS (17 000 PLN)

Information in the final report

  • Publication in academic press/journals (4)
  • Articles in post-conference publications (2)
  1. Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms
    Authors:
    Skrzypski M., Kakkassery M., Mergler S., Grötzinger C., Khajavi N., Sassek M., Szczepankiewicz D., Wiedenmann B., Nowak K.W., Strowski M.
    Academic press:
    Febs Letters (rok: 2013, tom: 587, strony: 3281-3287), Wydawca: Elsevier
    Status:
    Published
    DOI:
    10.1016/j.febslet.2013.08.025 - link to the publication
  2. Glucagon Regulates Orexin A Secretion in Humans and Rodents
    Authors:
    Arafat A. M, Kaczmarek P., Skrzypski M., Pruszyńska-Oszmalek E., Kołodziejski P., Adamidou A., Ruhla S., Szczepankiewicz D., Sassek M., Billert M., Wiedenmann B.,. Pfeiffer A. F.H,. Nowak K. W, Strowski M. Z.
    Academic press:
    Diabetologia (rok: 2014, tom: 57, strony: 2108-2116), Wydawca: Springer Science+Business Media
    Status:
    Published
    DOI:
    10.1007/s00125-014-3335-4 - link to the publication
  3. Orexin A modulates INS-1E cell proliferation and insulin secretion via extracellular signal-regulated kinase and transient receptor potential channels
    Authors:
    Skrzypski M., Khajavi N., Mergler S., Billert M., Szczepankiewicz M., Wojciechowicz M., Nowak K.W., Strowski M.Z.
    Academic press:
    Journal of Physiology and Pharmacology , Wydawca: POLISH PHYSIOLOGICAL SOC
    Status:
    Accepted for publication
    DOI:
    brak - link to the publication
  4. Chronic orexin-A treatment of male rats with type 2 diabetes improves glycemic control and protects β-cells against apoptotic death
    Authors:
    Kaczmarek P., Skrzypski M., Pruszyńska-Oszmałek E, Sassek M., Kołodziejski P.A., Kaczmarek P., Billert M., Szczepankiewicz D., Maechler P., Nowak K.W., Strowski M.Z. (P. K., M. Sk, E. PO contributed equally)
    Academic press:
    Endocrine , Wydawca: Springer
    Status:
    Submitted
    DOI:
    brak - link to the publication
  1. Orexin A improves glycemic control and pancreatic beta cells functions in animal model of type 2 diabetes
    Authors:
    M. Skrzypski, P. Kaczmarek, E. Pruszynska-Oszmalek, M. Sassek, P. A. Kolodziejski, M. Kaczmarek, M. Billert, D. Szczepankiewicz, K. Stupiak, P. Maechler, B. Wiedenmann, K.W. Nowak, M.Z. Strowski
    Conference:
    29th Congress of the Federation of the International Danube Symposia on Diabetes mellitus 9th Congress of Central European Diabetes Association, Jurmala, Latvia (rok: 2014, ), Wydawca: Verlag Kirchheim + Co GmbH
    Data:
    konferencja 26-28.07.2014
    Status:
    Published
  2. Orexin A stimulates INS-1E cell proliferation via ERK1/2-dependent signaling
    Authors:
    Billert M., Skrzypski M., Rogalska K., Kołodziejski P., Strowski M.Z., Nowak K.W.
    Conference:
    Bioopen I Ogólnopolska Konferencja Doktorantów Nauk o Życiu (rok: 2015, ), Wydawca: Uniwersytet Łódzki
    Data:
    konferencja 20-22 kwietnia
    Status:
    Published
    DOI:
    link to the publication

O Narodowym Centrum Nauki

Finansowanie nauki

Współpraca zagraniczna

Centrum prasowe

Deklaracja dostępności
Przetwarzanie danych osobowych
Polityka cookies

Partnerzy